aidsВИЧ-инфекция и иммуносупрессииHIV Infection and Immunosuppressive Disorders2077-9828Baltic Medical Education Center10.22328/2077-9828-2025-17-2-7-23aids-1012Research ArticleРЕДАКЦИОННАЯ СТАТЬЯ ПО РЕЗУЛЬТАТАМ НАУЧНО-ИССЛЕДОВАТЕЛЬСКОЙ РАБОТЫEDITORIAL ARTICLE BASED ON THE RESULTSOF THE STUDYРоль реактивации вирусов герпеса человека в патогенезе последствий коронавирусной инфекции COVID-19Editorial article based on the results of the study human herpes virus reactivation in the pathogenesis of long COVIDБоеваЕ. В.BoevaE. V.

Боева Екатерина Валериевна — кандидат медицинских наук, заведующая отделением хронической вирусной инфекции, врач-инфекционист; ассистент кафедры социально значимых инфекций и  фтизиопульмонологии

197101, Санкт-Петербург, ул. Мира, д. 14; 197022, Санкт-Петербург, ул. Льва Толстого, д. 6–8

 

St. Petersburg

kathrine.boeva@gmail.comhttps://orcid.org/0000-0002-1159-0101РассохинВ. В.RassokhinV. V.

Рассохин Вадим Владимирович — доктор медицинских наук, профессор, профессор кафедры социально значимых инфекций; ведущий научный сотрудник

197022, Санкт-Петербург, ул. Льва Толстого, д. 6–8; 197101, Санкт-Петербург, ул. Мира, д. 14

St. Petersburg

rasdoc@mail.ruhttps://orcid.org/0000-0001-6483-7043НоркаА. О.NorkaA. O.

Норка Анна Олеговна — кандидат медицинских наук, врач-невролог; ассистент кафедры

197101, Санкт-Петербург, ул. Мира, д. 14; 197022, Санкт-Петербург, ул. Льва Толстого, д. 6–8

St. Petersburg

norka-anna@mail.ruhttps://orcid.org/0009-0005-0049-8448КнижниковаА. А.KnizhnikovaA. A.

Книжникова Анастасия Александровна  — медицинский психолог отделения хронической вирусной инфекции; аспирант кафедры общей и клинической психологии

197101, Санкт-Петербург, ул. Мира, д. 14; 197022, Санкт-Петербург, ул. Льва Толстого, д. 6–8

St. Petersburg

nasya.sur@yandex.ruhttps://orcid.org/0000-0003-0535-5014КоробоваЗ. Р.KorobovaZ. R.

Коробова Зоя Романовна — кандидат медицинских наук, младший научный сотрудник лаборатории молекулярной иммунологии; ассистент кафедры иммунологии

197101, Санкт-Петербург, ул. Мира, д. 14; 197022, Санкт-Петербург, ул. Льва Толстого, д. 6–8

St. Petersburg

zoiakorobova@yandex.ruhttps://orcid.org/0000-0003-2490-308XАрсентьеваН. А.Arsent’yevaN. A.

Арсентьева Наталья Александровна — кандидат биологических наук, старший научный сотрудник лаборатории молекулярной иммунологии

197101, Санкт-Петербург, ул. Мира, д. 14

St. Petersburg

arsentieva_n.a@bk.ruhttps://orcid.org/0000-0002-4794-7475ИвановаА. Р.IvanovaA. R.

Иванова Анастасия Романовна — лаборант отделения диагностики ВИЧ-инфекции и СПИД-ассоциированных заболеваний

197101, Санкт-Петербург, ул. Мира, д. 14

St. Petersburg

Shinvy@inbox.ruКлементьевА. М.KlementevА. M.

Клементьев Александр Максимович — врач-инфекционист

191124, Санкт-Петербург, ул. Красного Текстильщика, д. 10–12, стр. 11

St. Petersburg

aklementev96@mail.ruБеляковН. А.BelyakovN. A.

Беляков Николай Алексеевич — доктор медицинских наук, профессор, академик Российской академии наук, заведующий кафедрой социально значимых инфекций и фтизиопульмонологии; руководитель Северо-Западного окружного центра по профилактике и борьбе со СПИДом 

197022, Санкт-Петербург, ул. Льва Толстого, д. 6–8; 197101, Санкт-Петербург, ул. Мира, д. 14

St. Petersburg

beliakov.akad.spb@yandex.ruСанкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени Пастера; «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияSt. Petersburg Pasteur InstituteRussian Federation«Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации; Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени ПастераРоссияSt. Petersburg Pasteur InstituteRussian FederationСанкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени Пастера; «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияSt. Petersburg Pasteur InstituteRussian FederationСанкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени Пастера; «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияSt. Petersburg Pasteur InstituteRussian FederationСанкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени ПастераРоссияSt. Petersburg Pasteur InstituteRussian Federation«Центр по профилактике и борьбе со СПИД и инфекционными заболеваниями»РоссияSt. Petersburg Pasteur InstituteRussian Federation202528072025172723Copyright © Боева Е.В., Рассохин В.В., Норка А.О., Книжникова А.А., Коробова З.Р., Арсентьева Н.А., Иванова А.Р., Клементьев А.М., Беляков Н.А., 20252025Боева Е.В., Рассохин В.В., Норка А.О., Книжникова А.А., Коробова З.Р., Арсентьева Н.А., Иванова А.Р., Клементьев А.М., Беляков Н.А.Boeva E.V., Rassokhin V.V., Norka A.O., Knizhnikova A.A., Korobova Z.R., Arsent’yeva N.A., Ivanova A.R., Klementev А.M., Belyakov N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://hiv.bmoc-spb.ru/jour/article/view/1012

Представленный аналитический обзор позволяет взглянуть на  проблему длительных последствий коронавирусной инфекции с позиции синергического взаимодействия возбудителей герпесвирусных инфекций и SARS-CoV-2. Авторы приводят данные о частоте встречаемости длительного постковидного синдрома (Long COVID), распространенности герпесвирусных заболеваний, возможных патогенетических и клинических пересечениях при формировании поствирусных последствий у человека. Описаны разнообразие клинических проявлений Long COVID, вероятные причины развития данных симптомов, а также представлены данные о потенциальной роли герпесвирусов человека в развитии поражений центральной нервной системы и формировании когнитивных нарушений. Особое внимание уделено иммунологическому звену в патогенезе ряда герпес-ассоциированных заболеваний и Long COVID. В настоящее время изучены и освещены не все механизмы поражений органов и систем при постковидном синдроме, особенно при взаимно усугубляющем влиянии коронавирусов и герпесвирусов человека. Дальнейшие исследования позволят получить новую информацию и более полную картину причинно-следственных связей при описании и объяснении ближайших и отдаленных последствий рассматриваемых вирусных инфекций, формирования Long COVID, а  также о  потенциальных целях для углубленного обследования пациентов и мерах терапевтических воздействий.

The analytical review allows us to look at the problem of long-term consequences of coronavirus infection from the standpoint of synergistic interaction of herpesvirus pathogens and SARS-CoV-2. The authors provide data of the incidence of long-term post-COVID syndrome (Long COVID), the prevalence of herpesvirus diseases, and possible pathogenetic and clinical intersections in the formation of post-viral consequences in humans. The variety of clinical manifestations of Long COVID, possible causes of these symptoms are described, and data of the potential role of human herpesviruses in the development of central nervous system lesions and the formation of cognitive impairment are presented. Particular attention is paid to the immunological link in the pathogenesis of a number of herpes-associated diseases and Long COVID. Currently, not all mechanisms of damage to organs and systems in post-COVID syndrome have been studied and discovered, especially with the mutually aggravating effects of coronaviruses and human herpesviruses. Further research will provide new information and a more complete picture of cause-and-effect relationships in describing and explaining the immediate and long-term consequences of the viral infections under consideration, the formation of Long COVID, as well as potential targets for in-depth examination of patients and therapeutic measures.

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The authors declare that there are no conflicts of interest present.