References

aids

ВИЧ-инфекция и иммуносупрессии

HIV Infection and Immunosuppressive Disorders

2077-9828

Baltic Medical Education Center

10.22328/2077-9828-2014-6-2-41-48

aids-20

Research Article

ЛЕКЦИЯ

LECTURE

СОСТОЯНИЕ ГИПОТАЛАМО-ГИПОФИЗАРНОЙ НАДПОЧЕЧНИКОВОЙ СИСТЕМЫ НА ФОНЕ ВИЧ-ИНФЕКЦИИ

HYPOTHALAMUS-PITUITARY-ADRENAL SYSTEM CONDITION IN HIV INFECTION

Сурженко

Дария Михайловна

Surzhenko

D. M.

makinad@mail.ru

Кузик

Валерий Владимирович

Kuzik

V. V.

office@iephb.ru

Санкт-Петербургский Центр по профилактике и борьбе со СПИД и инфекционными заболеваниями; Институт эволюционной физиологии и биохимии (ИЭФБ) им. И.М.Сеченова РАНРоссияSaint-Petersburg Center for Control of AIDS and Infectious Diseases; I.M.Sechenov Institute of Evolutionary Physiology and BiochemistryRussian Federation

Институт эволюционной физиологии и биохимии (ИЭФБ) им. И.М.Сеченова РАНРоссияI.M.Sechenov Institute of Evolutionary Physiology and BiochemistryRussian Federation

2014

30062014

624148

2014

Сурженко Д.М., Кузик В.В.

Surzhenko D.M., Kuzik V.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://hiv.bmoc-spb.ru/jour/article/view/20

ВИЧ-инфекцию часто сопровождают нарушения гипоталамо-гипофизарной надпочечниковой системы. Ее дисфункция на ранних стадиях заболевания проявляется в виде гиперкортизолемии, которую связывают с повышением уровня цитокинов, индуцирующих продукцию глюкокортикоидов. По мере прогрессирования ВИЧ-инфекции увеличивается вероятность развития надпочечниковой недостаточности в результате оппортунистических инфекций (чаще цитомегаловирусной) или неопластической инфильтрации надпочечников и/или гипофиза. Лекарственные препараты, использующиеся при терапии ВИЧ-инфекции, также могут способствовать развитию адреналовой недостаточности. Для дифференциальной диагностики состояний, напоминающих надпочечниковую недостаточность, и явной надпочечниковой недостаточности и для оценки резервной способности надпочечников необходимо выполнять диагностические тесты, поскольку необоснованная терапия глюкокортикоидами является опасной.

HIV infection is often accompanied by disorders in the hypothalamus-pituitary-adrenal system. Its dysfunctions at the early stages of the disease are manifested as increased blood cortisol, which is believed to be caused by increased cytokines able to enhance glucocorticoids production. With the further progression of HIV infection, the risk of adrenal failure increases because of opportunistic infections (most commonly cytomegaloviral) or neoplastic infiltration of adrenals and/or pituitary. Drugs used to treat HIV can also promote adrenal failure. For the differential diagnostics of the overt adrenal failure and conditions reminiscent of adrenal failure and for assessing the reserve capacity of adrenals, diagnostic test are expedient because unjustified therapy with glucocorticoids is unsafe.

надпочечникикортизолВИЧ-инфекциягормоныadrenalscortisolHIV infectionhormones

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