aidsВИЧ-инфекция и иммуносупрессииHIV Infection and Immunosuppressive Disorders2077-9828Baltic Medical Education Center10.22328/2077-9828-2017-9-1-7-21aids-235Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОРANALYTICAL REVIEWЗЛОКАЧЕСТВЕННЫЕ ОПУХОЛИ ПРИ ВИЧ-ИНФЕКЦИИ. ЭПИДЕМИОЛОГИЯ, ПАТОГЕНЕЗ, ФОРМЫ ОПУХОЛЕЙ. ЧАСТЬ 1MALIGNANT TUMORS IN HIV PATIENTS. EPIDEMIOLOGY, PATHOGENESIS, AND VARIABILITY. PART 1РассохинВ. В.RassokhinV. V.

Рассохин Вадим Владимирович — доктор медицинских наук, профессор кафедры социально-значимых инфекций СПбГМУ имени академика И.П.Павлова; ведущий научный сотрудник СПбНИИ ЭМ имени Пастера ведущий научный сотрудник0 отдела экологической физиологии ИЭМ.

197376, Санкт-Петербург, ул. Академика Павлова,  12, e-mail: ras-doc@mail.ru

ras-doc@mail.ruНекрасоваА. В.NekrasovaA. V.

Некрасова  Анастасия Викторовна — врач-онколог отделения онкологии № 2 (ХТ и ТКМ) НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой Первый СПбГМУ имени академика И.П.Павлова; врач-онколог ЦПБ СПИД ИЗ.

197376, Санкт-Петербург, ул. Академика Павлова,  12, e-mail: 9095842005onco@mail.ru

9095842005onco@mail.ruМихайловаН. Б.MikhailovaN. B.

Михайлова Наталья Борисовна — кандидат медицинских наук, руководитель отдела онкологии.

197376, Санкт-Петербург, ул. Академика Павлова, 12, e-mail: bmt.lymphoma@gmail.com

bmt.lymphoma@gmail.comПервый Санкт-Петербургский государственный медицинский университет имени академика И.П.Павлова; Санкт-Петербургский НИИ эпидемиологии и микробиологии имени Пастера; Институт экспериментальной медициныРоссияI.P.Pavlov SPbMU MON; Saint-Petersburg Paster Institute; IEMRussian FederationПервый Санкт-Петербургский государственный медицинский университет имени академика И.П.Павлова; Центр по профилактике и борьбе со СПИД и инфекционными заболеваниямиРоссияI.P.Pavlov SPbMU MON; Saint-Petersburg Center for Prevention and Control of AIDS and Infectious DiseasesRussian FederationПервый Санкт-Петербургский государственный медицинский университет имени академика И.П.ПавловаРоссияI.P.Pavlov SPbMU MONRussian Federation20170304201791721Copyright © Рассохин В.В., Некрасова А.В., Михайлова Н.Б., 20172017Рассохин В.В., Некрасова А.В., Михайлова Н.Б.Rassokhin V.V., Nekrasova A.V., Mikhailova N.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://hiv.bmoc-spb.ru/jour/article/view/235

В статье представлен обзор современной литературы о злокачественных новообразованиях при ВИЧ-инфекции, изучение которых стало актуально уже на заре появления первых случаев инфицирования ВИЧ-инфекцией в человеческой популяции. В клинике ВИЧ/СПИДа после разработки препаратов и программ для антиретровирусной терапии, внедрения эффективных методов профилактики и лечения оппортунистических инфекций онкологические заболевания приобретают лидирующие позиции в формировании наиболее тяжелых случаев течения ВИЧ-инфекции,  причин плохого прогноза и смерти пациентов. В статье дается анализ эпидемиологии злокачественных новообразований при ВИЧ-инфекции в мире и в России, представление о классификации, краткое описание патогенеза, клинических симптомов некоторых, наиболее актуальных злокачественных опухолей при ВИЧ-инфекции, подходы к их профилактике  и лечению.

Current literature on malignant neoplasms (MNP) in HIV patients is reviewed. NMP attracted attention when the very first HIV cases were found in humans. After ART drugs and therapeutic regiments and preventive and therapeutic interventions against opportunistic infections have been introduced in HIV clinics, MNP become the main cause of grave HIV cases, poor prognosis and lethal outcomes. In the present paper, NMP epidemiology in Russia and worldwide is analyzed, and the pathogenesis and symptoms of and therapeutic and preventive approaches to the most important HIV-associated  NMP are overviewed. 

ВИЧ-инфекцияСПИДэпидемиязлокачественные новообразованияиммуносупрессиягерпесвирусызлокачественные лимфомысаркома КапошиHIV infectionAIDSepidemicmalignant neoplasmsimmunosuppressionherpes virusesmalignant lymphomasKaposi sarcomaReferencesРассохин В.В., Фоменкова Н.В. Онкологические заболевания / Вирус иммунодефицита человека — медицина. СПб.: Балтийский медицинский образовательный центр, 2011. С. 286–304. [Rassokhin V.V., Fomenkova N.V. Cancer in Human immunodeficiency virus medicine. Saint-Petersburg: Baltic Medical Edicational Center, 2011, pp. 286–304 (In Russ.)].Рассохин В.В., Фоменкова Н.В. Онкологические заболевания / Вирус иммунодефицита человека — медицина. СПб.: Балтийский медицинский образовательный центр, 2011. С. 286–304. [Rassokhin V.V., Fomenkova N.V. Cancer in Human immunodeficiency virus medicine. Saint-Petersburg: Baltic Medical Edicational Center, 2011, pp. 286–304 (In Russ.)].Беляков Н.А., Рассохин В.В., Трофимова Т.Н., Степанова Е.В., Пантелеев А.М., Леонова О.Н., Бузунова С.А., Коновалова Н.В., Миличкина А.М., Тотолян А.А. Коморбидные и тяжелые формы ВИЧ-инфекции в России // ВИЧ-инфекция и иммуносупрессии. 2016. Т. 8, № 3. С. 9–24. [Belyakov N.A., Rassokhin V.V., Trofimova T.N., Stepanova Ye.V., Panteleev A.M., Leonova O.N., Buzunova S.A., Konovalova N.V., Milichkina A.M., Totolian A.A. Advanced and comorbid HIV cases in Russia. HIV Infection and Immunosuppressive Disorders, 2016, Vol. 8, No. 3, pp. 9–25 (In Russ.)].Беляков Н.А., Рассохин В.В., Трофимова Т.Н., Степанова Е.В., Пантелеев А.М., Леонова О.Н., Бузунова С.А., Коновалова Н.В., Миличкина А.М., Тотолян А.А. Коморбидные и тяжелые формы ВИЧ-инфекции в России // ВИЧ-инфекция и иммуносупрессии. 2016. Т. 8, № 3. С. 9–24. [Belyakov N.A., Rassokhin V.V., Trofimova T.N., Stepanova Ye.V., Panteleev A.M., Leonova O.N., Buzunova S.A., Konovalova N.V., Milichkina A.M., Totolian A.A. Advanced and comorbid HIV cases in Russia. HIV Infection and Immunosuppressive Disorders, 2016, Vol. 8, No. 3, pp. 9–25 (In Russ.)].Article M. Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996–2006: collaborative analysis of 13 HIV cohort studies. Clin. Infect. Dis., 2010, Vol. 50, No. 10, рр. 1387–1396.Article M. Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996–2006: collaborative analysis of 13 HIV cohort studies. Clin. Infect. Dis., 2010, Vol. 50, No. 10, рр. 1387–1396.Lewden C., May T., Rosenthal E., Burty C., Bonnet F., Costagliola D. Changes in causes of death among adults infected by HIV between 2000 and 2005: The Mortalité 2000 and 2005 surveys (ANRS EN19 and Mortavic). J. Acquir. Immune Defic. Syndr., 2008, Vol. 48, No. 5, pp. 590–598.Lewden C., May T., Rosenthal E., Burty C., Bonnet F., Costagliola D. Changes in causes of death among adults infected by HIV between 2000 and 2005: The Mortalité 2000 and 2005 surveys (ANRS EN19 and Mortavic). J. Acquir. Immune Defic. Syndr., 2008, Vol. 48, No. 5, pp. 590–598.Когда СПИД был раком. URL: https://parniplus.com/health/kogda-spid-byl-rakom (20.11.2016).Когда СПИД был раком. URL: https://parniplus.com/health/kogda-spid-byl-rakom (20.11.2016).World Health Organisation. ICD 10 [Electronic resource]. WHO. 2012. URL: http://www.dimdi.de/static/de/klassi/icd-10-gm/ind.World Health Organisation. ICD 10 [Electronic resource]. WHO. 2012. URL: http://www.dimdi.de/static/de/klassi/icd-10-gm/ind.Whitmore S., Glynn K.M., Dominguez K., Mitsch A., McKenna M.T. Revised surveillance case definitions for HIV infection among adults, adolescents, and children aged. MMWR. Recomm. Rep., 2008, Vol. 57, No. RR-10, рр. 1–12.Whitmore S., Glynn K.M., Dominguez K., Mitsch A., McKenna M.T. Revised surveillance case definitions for HIV infection among adults, adolescents, and children aged. MMWR. Recomm. Rep., 2008, Vol. 57, No. RR-10, рр. 1–12.Jones M.E., Swerdlow A.J. Bias in the standardized mortality ratio when using general population rates to estimate expected number of deaths. Am. J. Epidemiol., 1998, Vol. 148, No. 10, рр. 1012–1017.Jones M.E., Swerdlow A.J. Bias in the standardized mortality ratio when using general population rates to estimate expected number of deaths. Am. J. Epidemiol., 1998, Vol. 148, No. 10, рр. 1012–1017.Patel P., Hanson D.L., Sullivan P.S., Novak R.M., Moorman A.C., Tong T.C. Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992–2003. Ann. Intern. Med., 2008, Vol. 148, No. 10, рр. 728–736.Patel P., Hanson D.L., Sullivan P.S., Novak R.M., Moorman A.C., Tong T.C. Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992–2003. Ann. Intern. Med., 2008, Vol. 148, No. 10, рр. 728–736.Engels E.A., Pfeiffer R.M., Goedert J.J., Virgo P., McNeel T.S. Trends in cancer risk among people with AIDS in the United States 1980–2002. AIDS, 2006, Vol. 20, No. 12, рр. 1645–1654.Engels E.A., Pfeiffer R.M., Goedert J.J., Virgo P., McNeel T.S. Trends in cancer risk among people with AIDS in the United States 1980–2002. AIDS, 2006, Vol. 20, No. 12, рр. 1645–1654.Shiels M.S., Pfeiffer R.M., Hall H.I. Proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980–2007. Jama, 2011, Vol. 305, No. 14, рр 1450–1459.Shiels M.S., Pfeiffer R.M., Hall H.I. Proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980–2007. Jama, 2011, Vol. 305, No. 14, рр 1450–1459.Eltom M.A., Jemal A., Mbulaiteye S.M., Devesa S.S., Biggar R.J. Trends in Kaposi’s Sarcoma and Non-Hodgkin’s Lymphoma Incidence in the United States From 1973 Through 1998. Cancer, 2002, Vol. 94, No. 16, рр. 1204–1210.Eltom M.A., Jemal A., Mbulaiteye S.M., Devesa S.S., Biggar R.J. Trends in Kaposi’s Sarcoma and Non-Hodgkin’s Lymphoma Incidence in the United States From 1973 Through 1998. Cancer, 2002, Vol. 94, No. 16, рр. 1204–1210.Shiels M.S., Pfeiffer R.M., Gail M.H., Hall H.I., Li J., Chaturvedi A.K. Cancer burden in the HIV-infected population in the United States. J. Natl. Cancer Inst., 2011, Vol. 103, No. 9, рр. 753–762.Shiels M.S., Pfeiffer R.M., Gail M.H., Hall H.I., Li J., Chaturvedi A.K. Cancer burden in the HIV-infected population in the United States. J. Natl. Cancer Inst., 2011, Vol. 103, No. 9, рр. 753–762.Rubinstein P.G., Aboulafia D.M., Zloza A. Malignancies in HIV/AIDS: from epidemiology to therapeutic challenges. AIDS, 2014, Vol. 28, No. 4, рр. 453–465.Rubinstein P.G., Aboulafia D.M., Zloza A. Malignancies in HIV/AIDS: from epidemiology to therapeutic challenges. AIDS, 2014, Vol. 28, No. 4, рр. 453–465.Bedimo R., Chen R.Y., Accortt N.A., Raper J.L., Linn C., Allison J.J. Trends in AIDS-defining and non-AIDS-defining malignancies among HIVinfected patients: 1989–2002. Clin. Infect. Dis., 2004, Vol. 39, No. 1537–6591 (Electronic), рр. 1380–1384.Bedimo R., Chen R.Y., Accortt N.A., Raper J.L., Linn C., Allison J.J. Trends in AIDS-defining and non-AIDS-defining malignancies among HIVinfected patients: 1989–2002. Clin. Infect. Dis., 2004, Vol. 39, No. 1537–6591 (Electronic), рр. 1380–1384.Справка по ВИЧ-инфекции в Российской Федерации на 30 июня 2016 г. Федеральный научно-методический центр по профилактике и борьбе со СПИДом ФБУН «Центральный НИИ эпидемиологии» Роспотребнадзора. М., 2014. 296 с. [Clinical practice guidelines for the diagnosis and treatment of lymphoproliferative disorders. Moscow, 2014, 296 р. (In Russ.)].Справка по ВИЧ-инфекции в Российской Федерации на 30 июня 2016 г. Федеральный научно-методический центр по профилактике и борьбе со СПИДом ФБУН «Центральный НИИ эпидемиологии» Роспотребнадзора. М., 2014. 296 с. [Clinical practice guidelines for the diagnosis and treatment of lymphoproliferative disorders. Moscow, 2014, 296 р. (In Russ.)].Рассохин В.В., Леонова О.Н., Пантелеева О.В., Смирнова Н.Л., Фоменкова Н.В., Загдын З.М., Беляков Н.А. Частота и характер онкологических заболеваний у больных с ВИЧ-инфекцией до и на фоне применения высокоактивной антиретровирусной терапии // ВИЧ-инфекция и иммуносупрессии. 2012. Т. 4, № 4. С. 34–43. [Rassokhin V.V., Leonova O.N., Panteleyeva O.V., Smirnova N.L., Fomenkov N.V., Zagdyn Z.M., Belyakov N.A. Cancer incidences and features in HIV patients before and under HAART. HIV Infection and Immunosuppressive Disorders, 2012, Vol. 4, No. 4, рр. 34–43 (In Russ.)].Рассохин В.В., Леонова О.Н., Пантелеева О.В., Смирнова Н.Л., Фоменкова Н.В., Загдын З.М., Беляков Н.А. Частота и характер онкологических заболеваний у больных с ВИЧ-инфекцией до и на фоне применения высокоактивной антиретровирусной терапии // ВИЧ-инфекция и иммуносупрессии. 2012. Т. 4, № 4. С. 34–43. [Rassokhin V.V., Leonova O.N., Panteleyeva O.V., Smirnova N.L., Fomenkov N.V., Zagdyn Z.M., Belyakov N.A. Cancer incidences and features in HIV patients before and under HAART. HIV Infection and Immunosuppressive Disorders, 2012, Vol. 4, No. 4, рр. 34–43 (In Russ.)].Некрасова А.В., Леонова О.Н., Степанова Е.В., Рассохин В.В. Особенности развития злокачественных опухолей у пациентов с ВИЧинфекцией в Санкт-Петербурге // ВИЧ-инфекция и иммуносупрессии. 2016. Т. 8, № 1. С. 31–41. [Nekrasova А.V., Leonova O.N., Stepanova Ye.V., Rassokhin V.V. Characteristics of tumor development in HIV patients in Saint-Petersburg. HIV Infection and Immunosuppressive Disorders, 2014, Vol. 8, No. 1, рр. 31–41 (In Russ.)].Некрасова А.В., Леонова О.Н., Степанова Е.В., Рассохин В.В. Особенности развития злокачественных опухолей у пациентов с ВИЧинфекцией в Санкт-Петербурге // ВИЧ-инфекция и иммуносупрессии. 2016. Т. 8, № 1. С. 31–41. [Nekrasova А.V., Leonova O.N., Stepanova Ye.V., Rassokhin V.V. Characteristics of tumor development in HIV patients in Saint-Petersburg. HIV Infection and Immunosuppressive Disorders, 2014, Vol. 8, No. 1, рр. 31–41 (In Russ.)].ВИЧ инфекция и СПИД: клинические рекомендации / Под ред. В.В.Покровского. М.: ГЭОТАР-Медиа, 2010. 192 с. [HIV infection and AIDS: clinical recommendations. Еd. by V.V.Pokrovsky. Moscow: GEOTAR-Media, 2010, 192 р. (In Russ.)].ВИЧ инфекция и СПИД: клинические рекомендации / Под ред. В.В.Покровского. М.: ГЭОТАР-Медиа, 2010. 192 с. [HIV infection and AIDS: clinical recommendations. Еd. by V.V.Pokrovsky. Moscow: GEOTAR-Media, 2010, 192 р. (In Russ.)].Здравоохранение в России (2015 год). Федеральная служба государственной статистики. М., 2016. 174 с. [Health care in Russia (2015). Federal State Statistics Service. Moscow, 2016, 174 р. (In Russ.)].Здравоохранение в России (2015 год). Федеральная служба государственной статистики. М., 2016. 174 с. [Health care in Russia (2015). Federal State Statistics Service. Moscow, 2016, 174 р. (In Russ.)].Соколова Е.В., Покровский В.В. Ситуация по ВИЧ-инфекции в Российской Федерации // Терапевтический архив. 2013. Т. 85, № 11. С. 10–15. [Sokolova E.V., Pokrovsky V.V. The Situation on HIV infection in the Russian Federation. Therapeutic archive, 2013, Vol. 85, No. 11, рр. 10–15 (In Russ.)].Соколова Е.В., Покровский В.В. Ситуация по ВИЧ-инфекции в Российской Федерации // Терапевтический архив. 2013. Т. 85, № 11. С. 10–15. [Sokolova E.V., Pokrovsky V.V. The Situation on HIV infection in the Russian Federation. Therapeutic archive, 2013, Vol. 85, No. 11, рр. 10–15 (In Russ.)].Леви Дж.Э. ВИЧ и патогенез СПИДа / Под ред. Г.А.Игнатьевой. М.: Научный мир, 2010. 736 с. [Levi George E. HIV and pathogenesis of AIDS. Ed. by G.A. Ignatieva. Moscow: Scientific world, 2010, 736 р. (In Russ.)].Леви Дж.Э. ВИЧ и патогенез СПИДа / Под ред. Г.А.Игнатьевой. М.: Научный мир, 2010. 736 с. [Levi George E. HIV and pathogenesis of AIDS. Ed. by G.A. Ignatieva. Moscow: Scientific world, 2010, 736 р. (In Russ.)].Moore P.S., Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi’s sarcoma in patients with and without HIV infection. N. Engl. J. Med., 1995, Vol. 332, No. 18, рр. 1181–1185.Moore P.S., Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi’s sarcoma in patients with and without HIV infection. N. Engl. J. Med., 1995, Vol. 332, No. 18, рр. 1181–1185.Yarchoan R. Cancers in People with HIV and AIDS Progress and Challenges. Springer, 2014, 389 р.Yarchoan R. Cancers in People with HIV and AIDS Progress and Challenges. Springer, 2014, 389 р.De Martel C., Shiels M.S., Franceschi S., Simard E.P., Vignat J., Hall H.I., Engels E.A., Plummer M. Cancers attributable to infections among adults with HIV in the United States. AIDS, 2015, No. April, рр. 1.De Martel C., Shiels M.S., Franceschi S., Simard E.P., Vignat J., Hall H.I., Engels E.A., Plummer M. Cancers attributable to infections among adults with HIV in the United States. AIDS, 2015, No. April, рр. 1.Shepherd L. et al. Infection-related and -unrelated malignancies, HIV and the aging population. HIV Med., 2016, Vol. 17, No. 8, рр. 590–600.Shepherd L. et al. Infection-related and -unrelated malignancies, HIV and the aging population. HIV Med., 2016, Vol. 17, No. 8, рр. 590–600.Levy J.A. A new human herpesvirus: KSHV or HHV8? Lancet, 1995, Vol. 346, рр. 786.Levy J.A. A new human herpesvirus: KSHV or HHV8? Lancet, 1995, Vol. 346, рр. 786.Levy J.A., Ziegler J. Acquired immune deficiency syndrom (AIDS) is an opportunistic infection and Kaposi’s sarcoma results from secondary immune stimulation. Lancet, 1983, pр. 78–81.Levy J.A., Ziegler J. Acquired immune deficiency syndrom (AIDS) is an opportunistic infection and Kaposi’s sarcoma results from secondary immune stimulation. Lancet, 1983, pр. 78–81.Mesri E.A., Feitelson M.A., Munger K. Human viral oncogenesis: A cancer hallmarks analysis. Cell Host and Microbe, 2014, Vol. 15, No. 3, рр. 266–282.Mesri E.A., Feitelson M.A., Munger K. Human viral oncogenesis: A cancer hallmarks analysis. Cell Host and Microbe, 2014, Vol. 15, No. 3, рр. 266–282.Lo Re V., Kallan M.J., Tate J.P., Localio A.R., Lim J.K., Goetz M.B. Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: A cohort study. Ann. Intern. Med., 2014, Vol. 160, No. 6, рр. 369–379.Lo Re V., Kallan M.J., Tate J.P., Localio A.R., Lim J.K., Goetz M.B. Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: A cohort study. Ann. Intern. Med., 2014, Vol. 160, No. 6, рр. 369–379.Balfour H.H., Holman C.J., Hokanson K.M. Age-Specific prevalence of epstein-barr virus infection among individuals aged 6–19 years in the United States and factors affecting its acquisition. J. Infect. Dis., 2013, Vol. 208, No. 8, рр. 1286–1293.Balfour H.H., Holman C.J., Hokanson K.M. Age-Specific prevalence of epstein-barr virus infection among individuals aged 6–19 years in the United States and factors affecting its acquisition. J. Infect. Dis., 2013, Vol. 208, No. 8, рр. 1286–1293.Flavell K.J., Murray P.G. Hodgkin’s disease and the Epstein-Barr virus. Mol. Pathol., 2000, Vol. 53, No. 5, рр. 262–269.Flavell K.J., Murray P.G. Hodgkin’s disease and the Epstein-Barr virus. Mol. Pathol., 2000, Vol. 53, No. 5, рр. 262–269.Huynh D., Vincan E., Mantamadiotis T., Purcell D., Chan C.K., Ramsay R. Oncogenic properties of HIV-Tat in colorectal cancer cells. Curr. HIV Res., 2007, Vol. 5, No. 4, рр. 403–409.Huynh D., Vincan E., Mantamadiotis T., Purcell D., Chan C.K., Ramsay R. Oncogenic properties of HIV-Tat in colorectal cancer cells. Curr. HIV Res., 2007, Vol. 5, No. 4, рр. 403–409.Kim R.H., Yochim J.M., Kang M.K., Shin K.-H., Christensen R., Park N.H. HIV-1 tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome. Int. J. Oncol., 2008, Vol. 33, No. 4, рр. 777–782.Kim R.H., Yochim J.M., Kang M.K., Shin K.-H., Christensen R., Park N.H. HIV-1 tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome. Int. J. Oncol., 2008, Vol. 33, No. 4, рр. 777–782.Nakai-Murakami C., Desai B.M., Hwang D.S., Choo A.Y., Laddy D.J., Thieu K.P., HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination. Oncogene, 2007, Vol. 26, No. 4, рр. 477–486.Nakai-Murakami C., Desai B.M., Hwang D.S., Choo A.Y., Laddy D.J., Thieu K.P., HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination. Oncogene, 2007, Vol. 26, No. 4, рр. 477–486.Greenway A.L., McPhee D.A., Allen K., Johnstone R., Holloway G., Mills J., Azad A., Sankovich S., Lambert P. Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis. J. Virol., 2002, Vol. 76, No. 6, рр. 2692–2702.Greenway A.L., McPhee D.A., Allen K., Johnstone R., Holloway G., Mills J., Azad A., Sankovich S., Lambert P. Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis. J. Virol., 2002, Vol. 76, No. 6, рр. 2692–2702.Guiguet M., Boué F., Cadranel J., Lang J.M., Rosenthal E., Costagliola D. Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study. Lancet Oncol., 2009, Vol. 10, No. 12, рр. 1152–1159.Guiguet M., Boué F., Cadranel J., Lang J.M., Rosenthal E., Costagliola D. Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study. Lancet Oncol., 2009, Vol. 10, No. 12, рр. 1152–1159.Silverberg M.J. Chao C., Leyden W.A., Xu L., Horberg M.A., Klein D. HIV infection, immunodeficiency, viral replication, and the risk of cancer. Cancer Epidemiol. Biomarkers Prev., 2011, Vol. 20, No. 12, рр. 2551–2559.Silverberg M.J. Chao C., Leyden W.A., Xu L., Horberg M.A., Klein D. HIV infection, immunodeficiency, viral replication, and the risk of cancer. Cancer Epidemiol. Biomarkers Prev., 2011, Vol. 20, No. 12, рр. 2551–2559.Biggar R.J., Jaffe E.S., Goedert J.J., Chaturvedi A., Pfeiffer R., Engels E.A. Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS. Blood, 2006, Vol. 108, No. 12, рр. 3786–3791.Biggar R.J., Jaffe E.S., Goedert J.J., Chaturvedi A., Pfeiffer R., Engels E.A. Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS. Blood, 2006, Vol. 108, No. 12, рр. 3786–3791.Prosperi M.C., Сozzi-Lepri A., Castagna A., Mussini C., Murri R., Giacometti A. Incidence of malignancies in HIV-infected patients and prognostic role of current CD4 cell count: evidence from a large Italian cohort study. Clin. Infect. Dis., 2010, Vol. 50, No. 9, рр. 1316–1321.Prosperi M.C., Сozzi-Lepri A., Castagna A., Mussini C., Murri R., Giacometti A. Incidence of malignancies in HIV-infected patients and prognostic role of current CD4 cell count: evidence from a large Italian cohort study. Clin. Infect. Dis., 2010, Vol. 50, No. 9, рр. 1316–1321.Deeken J.F., Tjen-A-Looi A., Rudek M.A., Okuliar C., Young M., Little R.F., Dezube B.J. The rising challenge of non-AIDS-defining cancers in HIV-infected patients. Clin. Infect. Dis., 2012, Vol. 55, No. 9, рр. 1228–1235.Deeken J.F., Tjen-A-Looi A., Rudek M.A., Okuliar C., Young M., Little R.F., Dezube B.J. The rising challenge of non-AIDS-defining cancers in HIV-infected patients. Clin. Infect. Dis., 2012, Vol. 55, No. 9, рр. 1228–1235.Kawabata S., Heredia A., Gills J., Redfield R.R., Dennis P.A., Bryant J.L. Impact of HIV on lung tumorigenesis in an animal model. AIDS, 2015, Vol. 29, No. 5, рр. 633–635.Kawabata S., Heredia A., Gills J., Redfield R.R., Dennis P.A., Bryant J.L. Impact of HIV on lung tumorigenesis in an animal model. AIDS, 2015, Vol. 29, No. 5, рр. 633–635.Borges Á.H., Silverberg M.J., Wentworth D. Predicting risk of cancer during HIV infection: the role of inflammatory and coagulation biomarkers. AIDS, 2013, Vol. 27, No. 9, рр. 1433–1441.Borges Á.H., Silverberg M.J., Wentworth D. Predicting risk of cancer during HIV infection: the role of inflammatory and coagulation biomarkers. AIDS, 2013, Vol. 27, No. 9, рр. 1433–1441.Vendrame E. Serum levels of cytokines and biomarkers for inflammation and immune activation, and HIV-Associated non-hodgkin B-Cell lymphoma risk. Cancer Epidemiol. Biomarkers Prev., 2014, Vol. 23, No. 2, рр. 343–349.Vendrame E. Serum levels of cytokines and biomarkers for inflammation and immune activation, and HIV-Associated non-hodgkin B-Cell lymphoma risk. Cancer Epidemiol. Biomarkers Prev., 2014, Vol. 23, No. 2, рр. 343–349.Shiels M.S., Pfeiffer R.M., Hildesheim A., Engels E.A., Kemp T.J., Park J.-H., Katki H.A., Koshiol J., Shelton G., Caporaso N.E., Pinto L.A., Chaturvedi A.K. Circulating inflammation markers and prospective risk for lung cancer. J. Natl. Cancer Inst., 2013, Vol. 105, No. 24, рр. 1871–1880.Shiels M.S., Pfeiffer R.M., Hildesheim A., Engels E.A., Kemp T.J., Park J.-H., Katki H.A., Koshiol J., Shelton G., Caporaso N.E., Pinto L.A., Chaturvedi A.K. Circulating inflammation markers and prospective risk for lung cancer. J. Natl. Cancer Inst., 2013, Vol. 105, No. 24, рр. 1871–1880.Crum-Cianflone N., Hullsiek К.H., Marconi V., Weintrob A., Ganesan A., Barthel R.Vi., Fraser S., Agan B.K., Wegner S.L. Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study. AIDS, 2009, Vol. 23, рр. 41–50.Crum-Cianflone N., Hullsiek К.H., Marconi V., Weintrob A., Ganesan A., Barthel R.Vi., Fraser S., Agan B.K., Wegner S.L. Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study. AIDS, 2009, Vol. 23, рр. 41–50.Llibre J.M., Falco V., Tural C., Negredo E., Pineda J.A., Munoz J. The changing face of HIV/AIDS in treated patients. Curr. HIV Res., 2009, Vol. 7, рр. 365–377.Llibre J.M., Falco V., Tural C., Negredo E., Pineda J.A., Munoz J. The changing face of HIV/AIDS in treated patients. Curr. HIV Res., 2009, Vol. 7, рр. 365–377.Reekie J., Kosa C., Engsig F. Relationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignancies. Cancer, 2010, Vol. 116, рр. 5306–5315.Reekie J., Kosa C., Engsig F. Relationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignancies. Cancer, 2010, Vol. 116, рр. 5306–5315.Reynolds N.R. Cigarette smoking and HIV: More evidence for action. AIDS Education and Prevention, 2009, Vol. 21, Suppl. 3, pp. 106–121.Reynolds N.R. Cigarette smoking and HIV: More evidence for action. AIDS Education and Prevention, 2009, Vol. 21, Suppl. 3, pp. 106–121.Cadranel J., Garfield D., Lavolé A., Wislez M., Milleron B., Mayaud C. Lung cancer in HIV infected patients: facts, questions and challenges. Thorax, 2006, Vol. 61, No. 11, рр. 1000–1008.Cadranel J., Garfield D., Lavolé A., Wislez M., Milleron B., Mayaud C. Lung cancer in HIV infected patients: facts, questions and challenges. Thorax, 2006, Vol. 61, No. 11, рр. 1000–1008.Rahmanian S., Wewers M.E., Koletar S., Reynolds N., Ferketich A., Diaz P. Cigarette Smoking in the HIV-Infected Population. Proc. Am. Thorac. Soc., 2011, Vol. 8, No. 3, рр. 313–319.Rahmanian S., Wewers M.E., Koletar S., Reynolds N., Ferketich A., Diaz P. Cigarette Smoking in the HIV-Infected Population. Proc. Am. Thorac. Soc., 2011, Vol. 8, No. 3, рр. 313–319.Helleberg M., Afzal S., Kronborg G. Mortality attributable to smoking among HIV-1-infected individuals: A nationwide, population-based cohort study. Clin. Infect. Dis., 2013, Vol. 56, No. 5, рр. 727–734.Helleberg M., Afzal S., Kronborg G. Mortality attributable to smoking among HIV-1-infected individuals: A nationwide, population-based cohort study. Clin. Infect. Dis., 2013, Vol. 56, No. 5, рр. 727–734.Justice A., Sullivan L., Fiellin D. HIV/AIDS, Comorbidity, and Alcohol. Alcohol Res. Health, 2010, Vol. 33, No. 3, рр. 258–266.Justice A., Sullivan L., Fiellin D. HIV/AIDS, Comorbidity, and Alcohol. Alcohol Res. Health, 2010, Vol. 33, No. 3, рр. 258–266.Silverberg M.J., Lau B., Justice A.C., Engels E., Gill M.J., Goedert J.J., Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America. Clin. Infect. Dis., 2012, Vol. 54, No. 7, рр. 1026–1034.Silverberg M.J., Lau B., Justice A.C., Engels E., Gill M.J., Goedert J.J., Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America. Clin. Infect. Dis., 2012, Vol. 54, No. 7, рр. 1026–1034.Рассохин В.В. ВИЧ-инфекция и саркома Капоши // ВИЧ-инфекция и иммуносупрессии. 2012. Т. 4, № 4. С. 7–18. [Rassokhin V.V. HIV infection and kaposi sarcoma. HIV Infection and Immunosuppressive Disorders, 2012, Vol. 4, No. 4, рр. 7–18 (In Russ.)].Рассохин В.В. ВИЧ-инфекция и саркома Капоши // ВИЧ-инфекция и иммуносупрессии. 2012. Т. 4, № 4. С. 7–18. [Rassokhin V.V. HIV infection and kaposi sarcoma. HIV Infection and Immunosuppressive Disorders, 2012, Vol. 4, No. 4, рр. 7–18 (In Russ.)].Beachler D.C., DʼSouza G. Oral human papillomavirus infection, head, and neck cancers in HIV-infected individuals. Curr. Opin. Oncol., 2013, Vol. 25, No. 5, рр. 503–510.Beachler D.C., DʼSouza G. Oral human papillomavirus infection, head, and neck cancers in HIV-infected individuals. Curr. Opin. Oncol., 2013, Vol. 25, No. 5, рр. 503–510.Swerdlow S.H., Campo E., Harris N.L. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2008, 439 р.Swerdlow S.H., Campo E., Harris N.L. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2008, 439 р.Пивник А.В., Туманова М.В., Серегин Н.В., Пархоменко Ю.Г., Тишкевич О.А., Ковригина А.М., Ликунов Е.Б. Лимфомы у ВИЧ-инфицированных больных: обзор литературы // Онкогематология. 2014. Т. 7, № 3. С. 264–277. [Pivnik A.V., Tumanova M.V., Seregin N.V., Parkhomenko Yu.G., Tishkevich O.A., Kovrigina A.M., Likunov Е.B. Lymphomas in HIV-Infected Patients: Literature Review. Oncol., 2014, Vol. 7, No. 3, рр. 264–277 (In Russ.)].Пивник А.В., Туманова М.В., Серегин Н.В., Пархоменко Ю.Г., Тишкевич О.А., Ковригина А.М., Ликунов Е.Б. Лимфомы у ВИЧ-инфицированных больных: обзор литературы // Онкогематология. 2014. Т. 7, № 3. С. 264–277. [Pivnik A.V., Tumanova M.V., Seregin N.V., Parkhomenko Yu.G., Tishkevich O.A., Kovrigina A.M., Likunov Е.B. Lymphomas in HIV-Infected Patients: Literature Review. Oncol., 2014, Vol. 7, No. 3, рр. 264–277 (In Russ.)].Cesarman E. Pathology of lymphoma in HIV. Curr. Opin. Oncol., 2013, Vol. 25, No. 5, рр. 487–494.Cesarman E. Pathology of lymphoma in HIV. Curr. Opin. Oncol., 2013, Vol. 25, No. 5, рр. 487–494.Chao C., Silverberg M.J., Martínez-Maza O., Chi M., Abrams D.I., Haque R., Hongbin D. Epstein-Barr virus infection and expression of B-cell oncogenic markers in HIV-related diffuse large B-cell lymphoma. Clin. Cancer Res., 2012, Vol. 18, No. 17, рр. 4702–4712.Chao C., Silverberg M.J., Martínez-Maza O., Chi M., Abrams D.I., Haque R., Hongbin D. Epstein-Barr virus infection and expression of B-cell oncogenic markers in HIV-related diffuse large B-cell lymphoma. Clin. Cancer Res., 2012, Vol. 18, No. 17, рр. 4702–4712.Chadburn A., Chiu A., Lee J.Y. Immunophenotypic Analysis of AIDS-Related Diffuse Large B-Cell Lymphoma and Clinical Implications in Patients from AIDS Malignancies Consortium Clinical Trials 010 and 034. J. Clin. Oncol., 2009, Vol. 27, No. 30, рр. 5039–5048.Chadburn A., Chiu A., Lee J.Y. Immunophenotypic Analysis of AIDS-Related Diffuse Large B-Cell Lymphoma and Clinical Implications in Patients from AIDS Malignancies Consortium Clinical Trials 010 and 034. J. Clin. Oncol., 2009, Vol. 27, No. 30, рр. 5039–5048.Popova M., Zinina E., Popova N., Zhurba Y., Shneyder T., Karaygin I., Zuyzgin I., Ryabykina O., Ruzhinskaya O., Uspenskaya O., Medvedeva N., Klimovich A., Potapenko V., Kotova N., Myasnikov A., Moshnina S., Evseev A., Karyagina E., Stolypina Z., Dzola S., Levanov A., Borzenkova E., Mikhaylova N., Zubarovskay L., Afanasyev B. Current status of the epidemiology and outcome of lymphomas in HIV infected patients: a multicenter retrospective study. HIV Infection and Immunosuppressive Disorders, 2016, Vol. 8 (2), рр. 112–113.Popova M., Zinina E., Popova N., Zhurba Y., Shneyder T., Karaygin I., Zuyzgin I., Ryabykina O., Ruzhinskaya O., Uspenskaya O., Medvedeva N., Klimovich A., Potapenko V., Kotova N., Myasnikov A., Moshnina S., Evseev A., Karyagina E., Stolypina Z., Dzola S., Levanov A., Borzenkova E., Mikhaylova N., Zubarovskay L., Afanasyev B. Current status of the epidemiology and outcome of lymphomas in HIV infected patients: a multicenter retrospective study. HIV Infection and Immunosuppressive Disorders, 2016, Vol. 8 (2), рр. 112–113.Бублиевский Д.В., Евзиков Г.Ю. Первичная лимфома центральной нервной системы: клиника, диагностика, современные подходы к лечению // Нейрохирургия. 2012. № 1. С. 74–81. [Bublievskii D.V., Evsikov G.Yu. Primary lymphoma of the Central nervous system: clinic, diagnostics, modern approaches to treatment. Neurosurgery, 2012, No. 1, рр. 74–81 (In Russ.)].Бублиевский Д.В., Евзиков Г.Ю. Первичная лимфома центральной нервной системы: клиника, диагностика, современные подходы к лечению // Нейрохирургия. 2012. № 1. С. 74–81. [Bublievskii D.V., Evsikov G.Yu. Primary lymphoma of the Central nervous system: clinic, diagnostics, modern approaches to treatment. Neurosurgery, 2012, No. 1, рр. 74–81 (In Russ.)].Клинические рекомендации по диагностике и лечению лимфопролиферативных заболеваний / Общероссийский союз общественных объединений «Ассоциация онкологов России». М., 2014. 296 с. [Clinical practice guidelines for the diagnosis and treatment of lymphoproliferative disorders. Moscow, 2014, 296 р. (In Russ.)].Клинические рекомендации по диагностике и лечению лимфопролиферативных заболеваний / Общероссийский союз общественных объединений «Ассоциация онкологов России». М., 2014. 296 с. [Clinical practice guidelines for the diagnosis and treatment of lymphoproliferative disorders. Moscow, 2014, 296 р. (In Russ.)].Blinder V.S., Chadburn A., Furman R.R., Mathew S., Leonard J.P Improving outcomes for patients with Burkitt lymphoma and HIV. AIDS Patient Care STDS, 2008, Vol. 22, No. 3, рр. 175–187.Blinder V.S., Chadburn A., Furman R.R., Mathew S., Leonard J.P Improving outcomes for patients with Burkitt lymphoma and HIV. AIDS Patient Care STDS, 2008, Vol. 22, No. 3, рр. 175–187.Cesarman E. Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients. Cancer Letters, 2011, Vol. 305, No. 2, рр. 163–174.Cesarman E. Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients. Cancer Letters, 2011, Vol. 305, No. 2, рр. 163–174.Guech-Ongey M., Simard E.P., Anderson W.F., Engels E.A., Bhatia K., Devesa S.S. AIDS-related Burkitt lymphoma in the United States: What do age and CD4 lymphocyte patterns tell us about etiology and/or biology? Blood, 2010, Vol. 116, No. 25, рр. 5600–5604.Guech-Ongey M., Simard E.P., Anderson W.F., Engels E.A., Bhatia K., Devesa S.S. AIDS-related Burkitt lymphoma in the United States: What do age and CD4 lymphocyte patterns tell us about etiology and/or biology? Blood, 2010, Vol. 116, No. 25, рр. 5600–5604.Hamilton-Dutoit S.J., Rea D., Raphael M., Sandvej K., Delecluse H.J., Gisselbrecht C., Marelle L., van Krieken H.J., Pallesen G. Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related non-Hodgkin’s lymphoma. Correlation of lymphoma phenotype with three distinct patterns of viral latency. Am. J. Pathol., 1993, Vol. 143, No. 4, рр. 1072–1085.Hamilton-Dutoit S.J., Rea D., Raphael M., Sandvej K., Delecluse H.J., Gisselbrecht C., Marelle L., van Krieken H.J., Pallesen G. Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related non-Hodgkin’s lymphoma. Correlation of lymphoma phenotype with three distinct patterns of viral latency. Am. J. Pathol., 1993, Vol. 143, No. 4, рр. 1072–1085.Simonelli C., Spina M., Cinelli R. Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: a single-institution study. J. Clin. Oncol., 2003, Vol. 21, No. 21, рр. 3948–3954.Simonelli C., Spina M., Cinelli R. Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: a single-institution study. J. Clin. Oncol., 2003, Vol. 21, No. 21, рр. 3948–3954.Белохвостикова Т.С., Хороших О.В., Каня О.Н., Каня О.В., Капорская Т.С., Ребриков А.Н., Киселева Н.В., Верещагина С.А., Киселев И.В. Случай диагностики первичной выпотной лимфомы у ВИЧ-инфицированной пациентки // Онкогематология. 2011. Т. 4, № 4. С. 340–343 [Belokhvostikova T.S., Khoroshih O.V., Kanja O.N., Kanja O.V., Kaporskaja T.S., Rebrikov A.N., Kiseleva N.V., Vereshchagina S.A., Kiselyov I.V. Case of primary effusion lymphoma in the HIV-infected patient. Oncohematology, 2011, Vol. 4, No. 4, рр. 340–343 (In Russ.)].Белохвостикова Т.С., Хороших О.В., Каня О.Н., Каня О.В., Капорская Т.С., Ребриков А.Н., Киселева Н.В., Верещагина С.А., Киселев И.В. Случай диагностики первичной выпотной лимфомы у ВИЧ-инфицированной пациентки // Онкогематология. 2011. Т. 4, № 4. С. 340–343 [Belokhvostikova T.S., Khoroshih O.V., Kanja O.N., Kanja O.V., Kaporskaja T.S., Rebrikov A.N., Kiseleva N.V., Vereshchagina S.A., Kiselyov I.V. Case of primary effusion lymphoma in the HIV-infected patient. Oncohematology, 2011, Vol. 4, No. 4, рр. 340–343 (In Russ.)].Chen Y.B., Rahemtullah A., Hochberg E. Primary Effusion Lymphoma. Oncologist, 2007, Vol. 12, No. 5, рр. 569–576.Chen Y.B., Rahemtullah A., Hochberg E. Primary Effusion Lymphoma. Oncologist, 2007, Vol. 12, No. 5, рр. 569–576.Delecluse H.J., Anagnostopoulos I., Dallenbach F. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood, 1997, Vol. 89, No. 4, рр. 1413–1420.Delecluse H.J., Anagnostopoulos I., Dallenbach F. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood, 1997, Vol. 89, No. 4, рр. 1413–1420.Colomo L., Loong F., Rives S., Pittaluga S., Martinez A., Lopez-Guillermo A., Ojanguren J., Romagosa V., Jaffe E.S., Campo E. Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities. Am. J. Surg. Pathol., 2004, Vol. 28, No. 6, рр. 736–747.Colomo L., Loong F., Rives S., Pittaluga S., Martinez A., Lopez-Guillermo A., Ojanguren J., Romagosa V., Jaffe E.S., Campo E. Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities. Am. J. Surg. Pathol., 2004, Vol. 28, No. 6, рр. 736–747.Castillo J., Pantanowitz L., Dezube B.J. HIV-associated plasmablastic lymphoma: Lessons learned from 112 published cases. Am. J. Hematol., 2008, Vol. 83, No. 10, рр. 804–809.Castillo J., Pantanowitz L., Dezube B.J. HIV-associated plasmablastic lymphoma: Lessons learned from 112 published cases. Am. J. Hematol., 2008, Vol. 83, No. 10, рр. 804–809.Dupin N., Diss T.L., Kellam P. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood, 2000, Vol. 95, No. 4, рр. 1406–1412.Dupin N., Diss T.L., Kellam P. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood, 2000, Vol. 95, No. 4, рр. 1406–1412.Talat N., Schulte K.-M. Castleman’s Disease: Systematic Analysis of 416 Patients from the Literature. Oncologist, 2011, Vol. 16, No. 9, рр. 1316–1324.Talat N., Schulte K.-M. Castleman’s Disease: Systematic Analysis of 416 Patients from the Literature. Oncologist, 2011, Vol. 16, No. 9, рр. 1316–1324.Oksenhendler E., Duarte M., Soulier J. Multicentric Castleman’s disease in HIV infection: a clinical and pathological study of 20 patients. AIDS, 1996, Vol. 10, No. 1, рр. 61–67.Oksenhendler E., Duarte M., Soulier J. Multicentric Castleman’s disease in HIV infection: a clinical and pathological study of 20 patients. AIDS, 1996, Vol. 10, No. 1, рр. 61–67.Mounier N., Spina M., Spano J.P. Hodgkin lymphoma in HIV positive patients. Curr. HIV Res., 2010, Vol. 8, No. 2, рр. 141–146.Mounier N., Spina M., Spano J.P. Hodgkin lymphoma in HIV positive patients. Curr. HIV Res., 2010, Vol. 8, No. 2, рр. 141–146.Rezk S.A., Weiss L.M. Epstein-Barr virus-associated lymphoproliferative disorders. Human Pathology, 2007, Vol. 38, No. 9, рр. 1293–1304.Rezk S.A., Weiss L.M. Epstein-Barr virus-associated lymphoproliferative disorders. Human Pathology, 2007, Vol. 38, No. 9, рр. 1293–1304.Vaccher E., Spina M., Tirelli U. Clinical aspects and management of Hodgkin’s disease and other tumours in HIV-infected individuals. Eur. J. Cancer, 2001, Vol. 37, No. 10, рр. 1306–1315.Vaccher E., Spina M., Tirelli U. Clinical aspects and management of Hodgkin’s disease and other tumours in HIV-infected individuals. Eur. J. Cancer, 2001, Vol. 37, No. 10, рр. 1306–1315.Spina M., Berretta M., Tirelli U. Hodgkin’s disease in HIV. Hematol. Oncol. Clin. North Am., 2003, Vol. 17, No. 3, рр. 843–858.Spina M., Berretta M., Tirelli U. Hodgkin’s disease in HIV. Hematol. Oncol. Clin. North Am., 2003, Vol. 17, No. 3, рр. 843–858.Wilkins K., Turner R., Dolev J.C., LeBoit P.E., Berger T.G., Maurer T.A. Cutaneous malignancy and human immunodeficiency virus disease. J. Am. Acad. Dermatol., 2006, Vol. 54, No. 2, рр. 189–206.Wilkins K., Turner R., Dolev J.C., LeBoit P.E., Berger T.G., Maurer T.A. Cutaneous malignancy and human immunodeficiency virus disease. J. Am. Acad. Dermatol., 2006, Vol. 54, No. 2, рр. 189–206.Burg G., Kempf W., Kazakov D.V. Pyogenic lymphoma of the skin: A peculiar variant of primary cutaneous neutrophil-rich CD30+ anaplastic large-cell lymphoma. Clinicopathological study of four cases and review of the literature. Br. J. Dermatol., 2003, Vol. 148, No. 3, рр. 580–586.Burg G., Kempf W., Kazakov D.V. Pyogenic lymphoma of the skin: A peculiar variant of primary cutaneous neutrophil-rich CD30+ anaplastic large-cell lymphoma. Clinicopathological study of four cases and review of the literature. Br. J. Dermatol., 2003, Vol. 148, No. 3, рр. 580–586.Beylot-Barry M., Vergier B., Masquelier B., Bagot M., Joly P., Souteyrand P., Vaillant L., Avril M.F., Franck N., Fraitag S., Delaunay M., Laroche L., Estève E., Courville P., Dechelotte P. The spectrum of cutaneous lymphomas in HIV infection — A study of 21 cases. Am. J. Surg. Pathol., 1999, Vol. 23, No. 10, рр. 1208–1216.Beylot-Barry M., Vergier B., Masquelier B., Bagot M., Joly P., Souteyrand P., Vaillant L., Avril M.F., Franck N., Fraitag S., Delaunay M., Laroche L., Estève E., Courville P., Dechelotte P. The spectrum of cutaneous lymphomas in HIV infection — A study of 21 cases. Am. J. Surg. Pathol., 1999, Vol. 23, No. 10, рр. 1208–1216.Rodrigues L.K.E., Klencke B.J., Vin-Christian K., Berger T.G., Crawford R.I., Miller J.R., Ferreira C.M., Nosrati M., Kashani-Sabet M. Altered clinical course of malignant melanoma in HIV-positive patients. Arch. Dermatol., 2002, Vol. 138, No. June 2002, рр. 765–770.Rodrigues L.K.E., Klencke B.J., Vin-Christian K., Berger T.G., Crawford R.I., Miller J.R., Ferreira C.M., Nosrati M., Kashani-Sabet M. Altered clinical course of malignant melanoma in HIV-positive patients. Arch. Dermatol., 2002, Vol. 138, No. June 2002, рр. 765–770.Lobo D.V., Chu P., Grekin R.C. Nonmelanoma skin cancers and infection with the human immunodeficiency virus. Arch. Dermatol., 1992, Vol. 128, No. 5, рр. 623–627.Lobo D.V., Chu P., Grekin R.C. Nonmelanoma skin cancers and infection with the human immunodeficiency virus. Arch. Dermatol., 1992, Vol. 128, No. 5, рр. 623–627.Oram Y., Orengo I., Griego R.D., Rosen T., Thornby J. Histologic patterns of basal cell carcinoma based upon patient immunostatus. Dermatol., Surg., 1995, Vol. 21, No. 7, рр. 611–614.Oram Y., Orengo I., Griego R.D., Rosen T., Thornby J. Histologic patterns of basal cell carcinoma based upon patient immunostatus. Dermatol., Surg., 1995, Vol. 21, No. 7, рр. 611–614.Sitz K.V., Keppen M., Johnson D.F. Metastatic basal cell carcinoma in acquired immunodeficiency syndrome-related complex. JAMA, 1987, Vol. 257, No. 3, рр. 340–343.Sitz K.V., Keppen M., Johnson D.F. Metastatic basal cell carcinoma in acquired immunodeficiency syndrome-related complex. JAMA, 1987, Vol. 257, No. 3, рр. 340–343.Atarguine H. Cutaneous cryptococcosis mimicking basal cell carcinoma and revealing systemic involvement in acquired immunodeficiency. J. Mycol. Med., 2015, Vol. 25, No. 2, рр. 163–168.Atarguine H. Cutaneous cryptococcosis mimicking basal cell carcinoma and revealing systemic involvement in acquired immunodeficiency. J. Mycol. Med., 2015, Vol. 25, No. 2, рр. 163–168.Nguyen P., Vin-Christian K., Ming M.E., Berger T. Aggressive squamous cell carcinomas in persons infected with the human immunodeficiency virus. Arch. Dermatol., 2002, Vol. 138, No. 6, рр. 758–763.Nguyen P., Vin-Christian K., Ming M.E., Berger T. Aggressive squamous cell carcinomas in persons infected with the human immunodeficiency virus. Arch. Dermatol., 2002, Vol. 138, No. 6, рр. 758–763.Hengge U.R., Ruzicka T., Tyring S.K., Stuschke M., Roggendorf M. Update on Kaposi’s sarcoma and other HHV8 associated diseases. Part 2 : Pathogenesis, Castleman’s disease, and pleural effusion lymphoma. Lancet Infect. Dis., 2002, Vol. 2, No. June, рр. 344–352.Hengge U.R., Ruzicka T., Tyring S.K., Stuschke M., Roggendorf M. Update on Kaposi’s sarcoma and other HHV8 associated diseases. Part 2 : Pathogenesis, Castleman’s disease, and pleural effusion lymphoma. Lancet Infect. Dis., 2002, Vol. 2, No. June, рр. 344–352.Mehta S., Garg A., Gupta L., Kuldeep Chh.M. Kaposi’s sarcoma as a presenting manifestation of HIV. Indian J. Sex. Transm. Dis., 2011, Vol. 32, No. 2, рр. 108–110.Mehta S., Garg A., Gupta L., Kuldeep Chh.M. Kaposi’s sarcoma as a presenting manifestation of HIV. Indian J. Sex. Transm. Dis., 2011, Vol. 32, No. 2, рр. 108–110.Hu S.C.S., Ke C.L., Lee C.H., Wu C.S., Chen G.S., Cheng S.T. Dermoscopy of Kaposi’s sarcoma: Areas exhibiting the multicoloured «rainbow pattern». J. Eur. Acad. Dermatology Venereol., 2009, Vol. 23, No. 10, рр. 1128–1132.Hu S.C.S., Ke C.L., Lee C.H., Wu C.S., Chen G.S., Cheng S.T. Dermoscopy of Kaposi’s sarcoma: Areas exhibiting the multicoloured «rainbow pattern». J. Eur. Acad. Dermatology Venereol., 2009, Vol. 23, No. 10, рр. 1128–1132.Ho-Yen C., Chang F., van der Walt J., Lucas S. Gastrointestinal malignancies in HIV-infected or immunosuppressed patients: pathologic features and review of the literature. Adv. Anat. Pathol., 2007, Vol. 14, No. 6, рр. 431–443.Ho-Yen C., Chang F., van der Walt J., Lucas S. Gastrointestinal malignancies in HIV-infected or immunosuppressed patients: pathologic features and review of the literature. Adv. Anat. Pathol., 2007, Vol. 14, No. 6, рр. 431–443.Renwick N., Halaby T., Weverling G.J. Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi’s sarcoma. AIDS, 1998, Vol. 12, No. 18, рр. 2481–2488.Renwick N., Halaby T., Weverling G.J. Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi’s sarcoma. AIDS, 1998, Vol. 12, No. 18, рр. 2481–2488.Krown S.E., Metroka C., Wernz J.C. Kaposi’s sarcoma in the acquired immune deficiency syndrome: A proposal for uniform evaluation, response, and staging criteria. J. Clin. Oncol., 1989, Vol. 7, No. 9, рр. 1201–1207.Krown S.E., Metroka C., Wernz J.C. Kaposi’s sarcoma in the acquired immune deficiency syndrome: A proposal for uniform evaluation, response, and staging criteria. J. Clin. Oncol., 1989, Vol. 7, No. 9, рр. 1201–1207.Nawar E., Mbulaiteye S., Gallant J.E., Wohl D.A., Ardini M., Hendershot T. Risk factors for Kaposi’s sarcoma among HHV-8 seropositive homosexual men with AIDS. Int. J. Cancer, 2005, Vol. 115, No. 2, рр. 296–300.Nawar E., Mbulaiteye S., Gallant J.E., Wohl D.A., Ardini M., Hendershot T. Risk factors for Kaposi’s sarcoma among HHV-8 seropositive homosexual men with AIDS. Int. J. Cancer, 2005, Vol. 115, No. 2, рр. 296–300.

The authors declare that there are no conflicts of interest present.