aidsВИЧ-инфекция и иммуносупрессииHIV Infection and Immunosuppressive Disorders2077-9828Baltic Medical Education Center10.22328/2077-9828-2014-6-3-24-31aids-35Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESРЕЗИДЕНТНЫЕ МАКРОФАГИ ПЕЧЕНИ И АБСОЛЮТНОЕ ЧИСЛО ЦИРКУЛИРУЮЩИХ МОНОЦИТОВ ПРИ ХРОНИЧЕСКОМ ВИРУСНОМ ГЕПАТИТЕ СRESIDENT LIVER MACROPHAGES AND CIRCULATING MONOCYTE COUNTS IN CHRONIC VIRAL HEPATITIS CШевалдинАнатолий ГеннадьевичShevaldinA. G.shanatol@mail.ruПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П.ПавловаРоссияFirst Pavlov State Medical University of Saint-PetersburgRussian Federation201430092014632431Copyright © Шевалдин А.Г., 20142014Шевалдин А.Г.Shevaldin A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://hiv.bmoc-spb.ru/jour/article/view/35

Вероятность развития фиброза печени и примерные сроки его прогрессирования при хроническом гепатите С (ХГС) зависят от многих факторов. Исследования, посвященные взаимодействию клеток синусоидов печени редко упоминают резидентные макрофаги (клетки Купфера) в контексте хронических вирусных гепатитов. Помимо воспалительного процесса, Клетки Купфера могут инициировать фиброзирование в паренхиме печени посредством активации клеток Ито. В данной работе приводятся некоторые патоморфологические характеристики клеток Купфера и выявлена связь между их числом и абсолютным числом моноцитов периферической крови у больных с ХГС.

The probability of liver cirrhosis and the time course of its progression in chronic viral hepatitis C (VHC) depend on many factors. Studies of liver sinusal cell interactions rarely address resident macrophages (Kupffer cells) in the chronic viral hepatitis context. Besides inflammation, processes initiated by Kupffer cells include liver parenchima fibrosing caused by stellate cells activation. In the present study, certain pathomorphological features of Kupffer cells are recorded and a correlation between the number of the cells and the counts of monocytes in peripheral blood is found in chronic VHC patients.

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The authors declare that there are no conflicts of interest present.