aidsВИЧ-инфекция и иммуносупрессииHIV Infection and Immunosuppressive Disorders2077-9828Baltic Medical Education Center10.22328/2077-9828-2018-10-3-7-16aids-364Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОРANALYTICAL REVIEWКОМОРБИДНОСТЬ СИФИЛИСА И ВИЧ-ИНФЕКЦИИ: ОТРИЦАТЕЛЬНЫЙ ЭПИДЕМИОЛОГИЧЕСКИЙ И КЛИНИЧЕСКИЙ СИНЕРГИЗМSYPHILIS AND HIV COMORBIDITY: NEGATIVE CLINICAL AND EPIDEMIOLOGIC SYNERGYКрасносельскихТ. В.KrasnoselskikhT. V.

Красносельских Татьяна Валерьевна — доктор медицинских наук, профессор кафедры дерматовенерологии с клиникой

197022, Санкт-Петербург, ул. Льва Толстого, 6–8, корп. 4

tatiana.krasnoselskikh@gmail.comМанашеваЕ. Б.ManashevaЕ. B.

Манашева Елизавета Борисовна — старший лаборант кафедры дерматовенерологии с клиникой

197022, Санкт-Петербург, ул. Льва Толстого, 6–8, корп. 4

volf8989@mail.ruГезейM. А.GezeiM. А.

Гезей Мария Александровна — врач

190103, СанктПетербург, наб. Обводного канала, 179

mariya-gezej@yandex.ruФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П.Павлова» МЗ РФРоссияFSBEI HE I.P.Pavlov SPbMU MON RussiaRussian FederationСПб ГБУЗ «Центр СПИД и инфекционных заболеваний»РоссияCenter for AIDS and Other Infectious DiseasesRussian Federation201801102018103716Copyright © Красносельских Т.В., Манашева Е.Б., Гезей M.А., 20182018Красносельских Т.В., Манашева Е.Б., Гезей M.А.Krasnoselskikh T.V., Manasheva Е.B., Gezei M.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://hiv.bmoc-spb.ru/jour/article/view/364

В последнее время все большую актуальность приобретает проблема ведения больных, одновременно зараженных сифилисом и ВИЧ-инфекцией. Общность условий и путей передачи ВИЧ-инфекции и сифилиса, а также контингентов лиц, подверженных риску заражения, заставляет предполагать, что в ближайшие годы число случаев коинфекции будет возрастать. Доказан .отрицательный синергизм. ВИЧ-инфекции и сифилиса — то есть взаимное усиление негативного эффекта, когда каждая из болезней при их сочетании протекает более неблагоприятно, чем отдельное заболевание. Наличие сифилиса увеличивает вероятность заражения ВИЧ при незащищенном половом контакте и способствует прогрессированию ВИЧ-инфекции. С другой стороны, традиционно считается, что наличие ВИЧ-инфекции может существенно изменять клиническую картину и течение сифилиса, затруднять его диагностику и лечение, хотя широкое внедрение антиретровирусной терапии позволило существенно уменьшить этот негативный эффект. Обзорная статья посвящена проблеме биологического и эпидемиологического .синергизма. этих инфекций, а также анализу современных данных о клинических особенностях сифилиса, протекающего на фоне ВИЧ-инфекции.

Recently, management of patients co-infected with syphilis and HIV infection is becoming an increasingly important problem. Similarity of circumstances and ways of HIV and syphilis transmission as well as populations at risk of infection suggests that in the coming years the number of cases of co-infection will increase. The .negative synergy. of HIV infection and syphilis has been proven. This means a mutual reinforcement of the negative effect, when each of the diseases in their combination is more unfavorable than the separately existing disease. Syphilis increases the likelihood of HIV acquisition and transmission during unprotected sexual intercourse and contributes to the progression of HIV infection. On the other hand, it is traditionally believed that concomitant HIV infection can significantly change clinical features and course of syphilis and make its diagnosis and treatment more complicated. However, the widespread use of antiretroviral therapy has allowed to significantly reduce this negative effect. The review article is devoted to the problem of the biological and epidemiological .synergy. of these two infections, as well as to the analysis of modern data on the clinical features of syphilis developing against the background of HIV infection.

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The authors declare that there are no conflicts of interest present.