aidsВИЧ-инфекция и иммуносупрессииHIV Infection and Immunosuppressive Disorders2077-9828Baltic Medical Education Center10.22328/2077-9828-2019-11-3-57-63aids-463Research ArticleКОМОРБИДНЫЕ СОСТОЯНИЯ ПРИ ВИЧ-ИНФЕКЦИИУРОВЕНЬ ЦИТОКИНОВ В КРОВИ И ИХ СВЯЗЬ С ПОВРЕЖДЕНИЕМ ПЕЧЕНИ У ВИЧ-ИНФИЦИРОВАННЫХ ПАЦИЕНТОВ, КОИНФИЦИРОВАННЫХ ВИРУСОМ ГЕПАТИТА СBLOOD OF CYTOKINE LEVELS AND THEIR CORRELATIONS WITH LIVER INJURY IN PATIENTS COINFECTED WITH HIV AND HEPATITIS C VIRUSКоролевскаяЛ. Б.KorolevskayaL. B.

н.с. лаборатории экологической иммунологии

614081, Пермь, ул. Голева, 13

 

Perm

bioqueen@mail.ruСайдаковаЕ. В.SaydakovaE. V.

м.н.с. лаборатории экологической иммунологии «

614081, Пермь, ул. Голева, 13

 

Perm

radimira@list.ruШмагельК. В.ShmagelK. V.

д.м.н., зав. лабораторией экологической иммунологии

614081, Пермь, ул. Голева, 13 

Perm

shmagel@iegm.ruИнститут экологии и генетики микроорганизмов Уральского отделения Российской академии наук — филиал Пермского федерального исследовательского центра Уральского отделения Российской академии наукРоссияThe Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences — Brant of the Perm Federal Research Center, Ural Branch of the Russian Academy of SciencesRussian Federation2019140920191135763Copyright © Королевская Л.Б., Сайдакова Е.В., Шмагель К.В., 20192019Королевская Л.Б., Сайдакова Е.В., Шмагель К.В.Korolevskaya L.B., Saydakova E.V., Shmagel K.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://hiv.bmoc-spb.ru/jour/article/view/463

Цель работы: оценка уровня цитокинов в крови и их связи с показателями повреждения печени у ВИЧ-инфицированных пациентов, коинфицированных вирусом гепатита С. Материалы и методы. Был обследован 61 человек: ВИЧ/ВГС-коинфицированные пациенты (n=20), ВИЧ-моноинфицированные больные (n=21) и неинфицированные добровольцы (n=20). В плазме крови было определено содержание IL-6, IL-10, IL-5, TNF-a, VEGF, FGF basic, показатели повреждения печени (АСТ, АЛТ, APRI). Выявлено существенное увеличение уровня провоспалительных и противовоспалительных цитокинов в крови ВИЧ/ВГС-коинфицированных пациентов по сравнению с соответствующими показателями ВИЧ-моноинфицированных лиц. Установлена прямая связь между показателями повреждения печени и концентрациями исследованных цитокинов и ростовых факторов. Заключение. При хроническом воспалении повышенное содержание провоспалительных и противовоспалительных цитокинов в периферической крови и их связь с показателями повреждения печени может объяснять ускоренное фиброзирование печени у ВИЧ/ВГС-коинфицированных пациентов.

The aim of the study was to evaluate the levels of blood of cytokines and their correlations with indices of liver injury in patients coinfected with HIV and hepatitis C virus. Materials and methods. 61 persons were enrolled in the study: HIV/VHC coinfected patients (n=20), HIV monoinfected patients (n=21) and non-infected volunteers (n=20). Serum levels of IL-6, IL-10, IL-5, TNF-a, VEGF, FGF basic and biomarkers of liver injury (AST, SGPT, APRI) were measured. The significant increase in serum levels of proinflammatory and anti-inflammatory cytokines in HIV/VHC co-infected patients compared to the same indices in HIV mono-infected patients was detected. Positive correlation between biomarkers of liver injury and concentrations of observed cytokines and growth factors was found. Conclusion. In chronic inflammation, increased level of peripheral proinflammatory and anti-inflammatory cytokines and their associations with biomarkers of liver injury may explain accelerated liver fibrosis in HIV/HCV coinfected patients.

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The authors declare that there are no conflicts of interest present.