aidsВИЧ-инфекция и иммуносупрессииHIV Infection and Immunosuppressive Disorders2077-9828Baltic Medical Education Center10.22328/2077-9828-2020-12-4-23-31aids-579Research ArticleОБЗОРREVIEWХроническая обструктивная болезнь легких при ВИЧ-инфекцииChronic obstructive pulmonary disease and HIV-infectionhttps://orcid.org/0000-0002-5826-5517ВиктороваИ. Б.ViktorovaI. B.

Викторова Ирина Борисовна — кандидат медицинских наук, доцент кафедры фтизиопульмонологии Новокузнецкого государственного института усовершенствования врачей

654005, Кемеровская область, г. Новокузнецк, просп. Строителей, д. 5

Irina B. Viktorova

Novokuznetsk

irinaviktoroff@mail.ruЗиминаВ. Н.ZiminaV. N.

Зимина Вера Николаевна — доктор медицинских наук, профессор кафедры инфекционных болезней с курсами эпидемиологии и фтизиатрии медицинского института

117198, Москва, ул. Миклухо-Маклая, д. 6

Vera N. Zimina

Moscow

vera-zim@yandex.ruhttps://orcid.org/0000-0001-7857-3763КравченкоА. В.KravchenkoA. V.

Кравченко Алексей Викторович — доктор медицинских наук, профессор, ведущий научный сотрудник научно-исследовательского отдела эпидемиологии и профилактики СПИД

105275, Москва, 8-я ул. Соколиной горы, д. 15, корп. 2

Aleksey V. Kravchenko

Moscow

kravtchenko@hivrussia.netРоссийская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Continuous Professional EducationRussian FederationРоссийский университет дружбы народовРоссияPeoples’ friendship University of RussiaRussian FederationЦентральный научно-исследовательский институт эпидемиологииРоссияCentral Research Institute of EpidemiologyRussian Federation2020080220211242331Copyright © Викторова И.Б., Зимина В.Н., Кравченко А.В., 20212021Викторова И.Б., Зимина В.Н., Кравченко А.В.Viktorova I.B., Zimina V.N., Kravchenko A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://hiv.bmoc-spb.ru/jour/article/view/579

Повышение частоты регистрации неоппортунистических заболеваний органов дыхания при ВИЧ-инфекции обусловлено увеличением продолжительности жизни больных на фоне антиретровирусной терапии (АРТ). Обзор литературы посвящен хронической обструктивной болезни легких (ХОБЛ) — наиболее частому неинфекционному заболеванию легких, распространенность которого среди больных ВИЧ-инфекцией выше, чем в популяции.

В обзоре представлены актуальные сведения по состоянию проблемы сочетания ВИЧ-инфекции и ХОБЛ, приведены основные механизмы формирования и течения ХОБЛ при ВИЧ-инфекции, а также факторы, способствующие взаимному влиянию коморбидных состояний. Отдельно освещены особенности терапии ХОБЛ на фоне проведения АРТ и представлены сведения о значимых лекарственных взаимодействиях между некоторыми классами медикаментов для базисной терапии ХОБЛ и антиретровирусными препаратами.

Социально-экономическая значимость обеих нозологий обосновывает более широкое информирование пульмонологов, терапевтов и инфекционистов об особенностях течения и терапии ХОБЛ при ВИЧ-инфекции.

The increasing life expectancy of HIV-infected persons due to antiretroviral therapy (ART) is associated with growing frequency of non-opportunistic respiratory diseases. This review of literature is devoted to chronic obstructive pulmonary disease (COPD), which is known to be the most common chronic noninfectious lung condition in HIV-patients. The prevalence of COPD in the global population with HIV is high and is associated with HIV.

The article contains actual data on HIV/COPD comorbidity, presents current information on mechanism of COPD development in HIV-infection, factors contributing to the mutual influence and adverse course of comorbid conditions. The specialties of COPD treatment during ART and clinically significant drug interactions between different COPD medications and some antiretrovirals are highlighted.

The socio-economic significance of both HIV-infection and COPD argues wide informing of pulmonologists, therapists and infectious disease specialists about the course and treatment of COPD in persons with HIV-infection.

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The authors declare that there are no conflicts of interest present.