aidsВИЧ-инфекция и иммуносупрессииHIV Infection and Immunosuppressive Disorders2077-9828Baltic Medical Education Center10.22328/2077-9828-2014-6-4-88-91aids-60Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL RESEARCHОПТИМИЗАЦИЯ ЛЕЧЕНИЯ ХГС 1 ГЕНОТИПА В РОССИИ - ВЗГЛЯД КЛИНИЦИСТАOPTIMISATION OF THERAPY FOR GENOTYPE 1 HCV IN RUSSIA CLINICIAN'S VIEWКижлоСветлана НиколаевнаKizhloS. N.noemail@neicon.ruСанкт-Петербургский центр по профилактике и борьбе со СПИД и инфекционными заболеваниямиРоссияSaint-Petersburg Center for Control of AIDS and Infectious DiseasesRussian Federation201430122014648891Copyright © Кижло С.Н., 20142014Кижло С.Н.Kizhlo S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://hiv.bmoc-spb.ru/jour/article/view/60

У первичных больных хроническим гепатитом С (ХГС) симепревир в составе комбинированной (противовирусной терапии) ПВТ обеспечивает устойчивый вирусологический ответ (УВО) в 80,4% случаев (в контроле - 50%, QUEST-1+QUEST-2).

In primary HCV patints, Simeprevir as a component of combined antiviral therapy provides for stavle virological responces in 80,4% of cases vs. 50% in control (QUEST-1+QUEST-2).

Ингибиторы протеазы ХГСSimeprevirSMVHCV protease inhibitorsSimeprevirReferencesJacobson I., Dore G.J., Foster G.R. Fried M.W., Radu M., Rafalskiy V.V., Moroz L., Craxi A., Peeters M., Lenz O., Ouwerkerk-Mahadevan S., Kalmeijer R., Beumont-Mauviel M. Simeprevir (TMC435) with peginterferon/ribavirin for chronic HCV genotype-1 infection n treatment-naive patients: results from QUEST-1, a phase III trial. 48th Annual Meeting of the European Association for the Study of the Liver, April 24-28, 2013, Amsterdam, Netherlands; abstract 1425.- URL: http://www.natap.org/2013/EASL/EASL_106.htmJacobson I., Dore G.J., Foster G.R. Fried M.W., Radu M., Rafalskiy V.V., Moroz L., Craxi A., Peeters M., Lenz O., Ouwerkerk-Mahadevan S., Kalmeijer R., Beumont-Mauviel M. Simeprevir (TMC435) with peginterferon/ribavirin for chronic HCV genotype-1 infection n treatment-naive patients: results from QUEST-1, a phase III trial. 48th Annual Meeting of the European Association for the Study of the Liver, April 24-28, 2013, Amsterdam, Netherlands; abstract 1425.- URL: http://www.natap.org/2013/EASL/EASL_106.htmJacobson I.M., Dore G.J., Foster G. et al. Simeprevir (TMC435) with Peginterferon/ Ribavirin for Chronic HCV Genotype-1 Infection in Treatment-Naive Patients: Results From QUEST-1, a Phase III Trial. Digestive Disease Week, Orlando, 2013.- A. Sa2072.Jacobson I.M., Dore G.J., Foster G. et al. Simeprevir (TMC435) with Peginterferon/ Ribavirin for Chronic HCV Genotype-1 Infection in Treatment-Naive Patients: Results From QUEST-1, a Phase III Trial. Digestive Disease Week, Orlando, 2013.- A. Sa2072.Manns M., Marcellin P., Poordad F.P., Stanislau Affonso de Araujo E., Buti M., Horsmans Y., Janczewska E., Villamil F., Peeters M., Lenz O., Ouwerkerk-Mahadevan S., Kalmeijer R., Beumont-Mauviel M. Simeprevir (TMC435) with peginterferon/ribavirin for chronic HCV genotype-1 infection n treatment-naive patients: results from QUEST-2, a phase III trial. 48th Annual Meeting of the European Association for the Study of the Liver, April 24-28, 2013, Amsterdam, Netherlands; abstract 1413.- URL: http://www.natap.org/2013/EASL/EASL_106.htmManns M., Marcellin P., Poordad F.P., Stanislau Affonso de Araujo E., Buti M., Horsmans Y., Janczewska E., Villamil F., Peeters M., Lenz O., Ouwerkerk-Mahadevan S., Kalmeijer R., Beumont-Mauviel M. Simeprevir (TMC435) with peginterferon/ribavirin for chronic HCV genotype-1 infection n treatment-naive patients: results from QUEST-2, a phase III trial. 48th Annual Meeting of the European Association for the Study of the Liver, April 24-28, 2013, Amsterdam, Netherlands; abstract 1413.- URL: http://www.natap.org/2013/EASL/EASL_106.htmPoordad F., Manns M.P., Marcellin P. et al. Simeprevir (TMC435) with Peginterferon/Ribavirin for Treatment of Chronic HCV Genotype-1 Infection in Treatment-Naive Patients: Results From QUEST-2, a Phase III Trial. Digestive Disease Week, Orlando, 2013, A. 869a.Poordad F., Manns M.P., Marcellin P. et al. Simeprevir (TMC435) with Peginterferon/Ribavirin for Treatment of Chronic HCV Genotype-1 Infection in Treatment-Naive Patients: Results From QUEST-2, a Phase III Trial. Digestive Disease Week, Orlando, 2013, A. 869a.Руководство EACS, 2013 год. / EACS Брюссель, 2013.- URL:http://arvt.ru/news/2013-10-30-EACS7.0.html.- 82 с.Руководство EACS, 2013 год. / EACS Брюссель, 2013.- URL:http://arvt.ru/news/2013-10-30-EACS7.0.html.- 82 с.Dieterich D., Rockstroh J., Orkin C. Simeprevir (TMC435) Plus PegIFN/Ribavirin in HCV Genotype-1/HIV-1 Coinfection (Study C212). 21st Conference on Retroviruses and Opportunistic Infections, March 3-6, 2014; abstract 24.- URL: http://www.natap.org/2014/CROI/croi_110.htm.Dieterich D., Rockstroh J., Orkin C. Simeprevir (TMC435) Plus PegIFN/Ribavirin in HCV Genotype-1/HIV-1 Coinfection (Study C212). 21st Conference on Retroviruses and Opportunistic Infections, March 3-6, 2014; abstract 24.- URL: http://www.natap.org/2014/CROI/croi_110.htm.

The authors declare that there are no conflicts of interest present.