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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">aids</journal-id><journal-title-group><journal-title xml:lang="ru">ВИЧ-инфекция и иммуносупрессии</journal-title><trans-title-group xml:lang="en"><trans-title>HIV Infection and Immunosuppressive Disorders</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-9828</issn><publisher><publisher-name>Baltic Medical Education Center</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22328/2077-9828-2022-14-4-80-86</article-id><article-id custom-type="elpub" pub-id-type="custom">aids-756</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Место радикальной хирургии в лечении туберкулеза центральной нервной системы в сочетании с ВИЧ-инфекцией</article-title><trans-title-group xml:lang="en"><trans-title>Place of radical surgery in tuberculosis treatment of central nervous system in combination with HIV infection</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5132-5417</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>C. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петров Сергей Иннокентьевич — к.м.н., доцент кафедры травматологии, ортопедии и нейрохирургии;  заведующий нейрохирургическим отделением </p><p>664049, г. Иркутск, м-н Юбилейный, д. 100</p></bio><bio xml:lang="en"><p>Irkutsk </p></bio><email xlink:type="simple">neuropet.sp@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5940-4283</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новицкая</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Novitskaya</surname><given-names>О. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новицкая Ольга Николаевна — д.м.н., начальник</p><p>664039, г. Иркутск, ул. Терешковой, д. 59</p></bio><bio xml:lang="en"><p>Irkutsk </p></bio><email xlink:type="simple">olga19701604@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Иркутская медицинская академия последипломного образования; Иркутская областная клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Irkutsk Medical Academy of Postgraduate Education; Irkutsk Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Иркутская областная клиническая туберкулезная больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Irkutsk Regional Tuberculosis Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>24</day><month>01</month><year>2023</year></pub-date><volume>14</volume><issue>4</issue><fpage>80</fpage><lpage>86</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Петров С.И., Новицкая О.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Петров С.И., Новицкая О.Н.</copyright-holder><copyright-holder xml:lang="en">Petrov C.I., Novitskaya О.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://hiv.bmoc-spb.ru/jour/article/view/756">https://hiv.bmoc-spb.ru/jour/article/view/756</self-uri><abstract><sec><title>Цель</title><p>Цель. На основании собственного материала определить роль радикальных хирургических методов в лечении туберкулезных образований головного мозга у ВИЧ-инфицированных больных.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Изучены: статистические формы ОГБУЗ ИОКТБ за период с 2008 по 2020 г., данные ФРБТ за 2017–2020 гг., характер течения болезни у 56, многолетняя динамика болезни — у 8, аутопсийный материал 331 умерших и биопсийный — 9 оперированных пациентов с поражением центральной нервной системы (ЦНС).</p><p>Результаты и их обсуждение. Число больных туберкулезным менингоэнцефалитом в структуре стационаров увеличивается, летальность среди них растет. Потребность в нейрохирургической помощи среди выживших составляет 25%. Многолетнее наблюдение за прооперированными демонстрирует их высокую выживаемость, значительный клинический эффект операции, удлинение жизни, нарастание CD4 лимфоцитов в 2,7 раза через 3,5 года после операции. Отмечено формирование отграничительных процессов вокруг туберкулезных очагов в ЦНС при приеме АРВТ при низком иммунном статусе.</p></sec><sec><title>Заключение</title><p>Заключение. Радикальное удаление туберкулезных образований ЦНС при ВИЧ целесообразно</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. On the basis of own material determine the role of radical surgery methods in treating tubercular formations of the brain in HIV-infected patients.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods. Studied: statistical forms of the SSPB of the IOKB from 2008 to 2020, FTBPR data from 2017 to 2020, nature of the disease in 56, long-term disease dynamics — in 8, the autopsy material of 331 dead and the biopsy — 9 patients operated on with central nervous system damage (CNS).</p></sec><sec><title>Results and Discussion</title><p>Results and Discussion. The number of patients with tuberculous meningoencephalitis increases in the structure of in-patient facilities, case-fatality rate among them grows. Need for neurosurgical care among the survivors is 25%. Long-term monitoring of operatively treated patients shows their higher survival rate, significant clinical effect of surgery, lengthening of life, increase of CD4 lymphocytes by 2,7 times in 3,5 years after the surgery. Formation of restrictive processes around tuberculous lesion in CNS was noted when taking ART with low immune status.</p></sec><sec><title>Conclusion</title><p>Conclusion. Radical removal of tubercular formations of CNS in HIV is reasonable.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>головной мозг</kwd><kwd>ВИЧ</kwd><kwd>нейрохирургия</kwd><kwd>туберкулез</kwd><kwd>туберкулезный абсцесс</kwd><kwd>туберкулема</kwd></kwd-group><kwd-group xml:lang="en"><kwd>brain</kwd><kwd>HIV</kwd><kwd>neurosurgery</kwd><kwd>tuberculosis</kwd><kwd>tuberculosis abscess</kwd><kwd>tuberculoma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Арутюнов А.И., Зозуля Ю.А., Оганесян С.С. Туберкулемы головного мозга. Киев: Государственное медицинское издательство УССР, 1959. 199 с.</mixed-citation><mixed-citation xml:lang="en">Arutyunov A. I., Zozulya Yu. A., Oganesyan S. S. Tuberculosis of the brain. Kiev: State Medical Publishing house of the Ukrainian SSR, 1959. 199 p. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Улитин А.Ю., Олюшин В.Е., Размологова О.Ю., Савченко А.И., Щербинин А.В. Туберкулема головного мозга: клинический случай и обзор литературы // Нейрохирургия. 2007. № 1. С. 40–44.</mixed-citation><mixed-citation xml:lang="en">Ulitin A.Yu., Olyushin V.E., Razmologova O.Yu., Savchenko A.I., Shcherbinin A.V. Tuberculosis of the brain: a clinical case and a literature review. Neurosurgery, 2007, No. 1, pp. 40–44 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Rajshekhar V. Surgery for brain tuberculosis: a review // Acta Neurochir. 2015. Vol. 157, No. 10. P. 1665–1678. PMID: 26170188. doi: 10.1007/s00701-015-2501-x.</mixed-citation><mixed-citation xml:lang="en">Rajshekhar V. Surgery for brain tuberculosis: a review // Acta Neurochir. 2015. Vol. 157, No. 10. P. 1665–1678. PMID: 26170188. doi: 10.1007/s00701-015-2501-x.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma M., Velho V., Kharosekar H. A rare case of an isolated intraventricular tuberculoma with a dismal outcome: an unusual location of a common pathology and lessons learnt // Indian J. Tuberc. 2014. Vol. 61, No. 2. P. 166–170.</mixed-citation><mixed-citation xml:lang="en">Sharma M., Velho V., Kharosekar H. A rare case of an isolated intraventricular tuberculoma with a dismal outcome: an unusual location of a com-mon pathology and lessons learnt // Indian J. Tuberc. 2014. Vol. 61, No. 2. P. 166–170.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Tewary R.K., O’Sullivan M.G., Ali T.A., O’Sullivan P.G. Intracranial tuberculoma — a diagnostic dilemma // J. Laryngol. 2005. Vol. 119, No. 6. P. 486–488. PMID: 15992480. doi: 10.1258/0022215054273061.</mixed-citation><mixed-citation xml:lang="en">Tewary R.K., O’Sullivan M.G., Ali T.A., O’Sullivan P.G. Intracranial tuberculoma — a diagnostic dilemma // J. Laryngol. 2005. Vol. 119, No. 6. P. 486–488. PMID: 15992480. doi: 10.1258/0022215054273061.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Yadegarynia D., Merza M.A., Sali S., Seghatoleslami Z.S. Multiple intracranial tuberculomas in a post-kidney transplant patient // Saudi J Kidney Dis Transpl. 2016. Vol. 27, No. 1. P. 135–138. PMID: 26787580 DOI: 10.4103/1319-2442.174163.</mixed-citation><mixed-citation xml:lang="en">Yadegarynia D., Merza M.A., Sali S., Seghatoleslami Z.S. Multiple intracranial tuberculomas in a post-kidney transplant patient // Saudi J Kidney Dis Transpl. 2016. Vol. 27, No. 1. P. 135–138. PMID: 26787580 DOI: 10.4103/1319-2442.174163.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Филиппова Т.П., Новицкая О.Н., Быков Ю.Н., Корнилова З.Х. ВИЧ-ассоциированный туберкулез центральной нервной системы в регионе с высоким уровнем распространения туберкулеза и ВИЧ-инфекции. Москва: Р. Валент, 2012. 132 с.</mixed-citation><mixed-citation xml:lang="en">Filippova T.P., Novitskaya O.N., Bykov Yu.N., Kornilova Z.H. HIV-associated tuberculosis of the central nervous system in a region with a high level of tuberculosis and HIV infection. Moscow: Publishing house R. Valent, 2012. 132 p. (In Russ.)].</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
