ANTIRETROVIRAL THERAPY FOR HIV INFECTION: PROSPECTS FOR SIMPLIFIED THERAPEUTIC REGIMENS
https://doi.org/10.22328/2077-9828-2017-9-2-27-35
Abstract
Literature on current approaches to ART for HIV; control of HIV resistance to ART; and virologic and clinical criteria for ART and on the evaluation of ART regimens limited to monotherapy or the use of two ART drugs is reviewed. Viral load below 50 RNA copies per 1 mL is the most important criterion of ART efficacy and provides for preventing HIV resistance to ART. Simplified ART regimens make it possible to reduce adverse events and drug interactions; to enhance adherence to therapy; and to decrease the cost of ART. Such regimens are applicable to patients who show viral load suppression below 50 mL–1 upon standard three-component ART regimens; never had severe immunosuppression (CD4 T-cell counts below 200 mL–1); are highly adherent to therapy; and are under strict virological monitoring.
Keywords
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For citations:
Matiyevskaya N.V. ANTIRETROVIRAL THERAPY FOR HIV INFECTION: PROSPECTS FOR SIMPLIFIED THERAPEUTIC REGIMENS. HIV Infection and Immunosuppressive Disorders. 2017;9(2):27-35. (In Russ.) https://doi.org/10.22328/2077-9828-2017-9-2-27-35
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