THE MOLECULAR EPIDEMIOLOGICAL ANALYSIS OF HIV INFECTION IN SAKHALIN REGION, RUSSIA
https://doi.org/10.22328/2077-9828-2017-9-3-113-120
Abstract
The results of the molecular epidemiological analysis of HIV-1 variants circulating in Sakhalin Oblast were presented. The HIV-1 viruses belonging to subtype A were dominated (81,14%). Besides these variants, viruses of another subtypes such as B, G and recombinant forms CRF63_02A1, URF02_AG, CRF11_cpx were identified. According to phylogenetic analysis, subtype A sequences formed the common branch with nucleotide sequences of A6 strains found in other regions of Russia. The recombinant strain CRF63_02A1 formed the common branch with HIV-1 sequences from Siberia and Russian Far East. Additional analysis using the jpHMM program revealed two unique recombinant forms (URF02_AG) formed by HIV-1 subtypes A and G. Among the viruses of subtype B, the BFSU strain, which is now widely distributed in Ukraine, has been identified. For the first time in Russia, the recombinant CRF11_cpx was detected on the Sakhalin region territory.
About the Authors
A. S. Tumanov
D.I.Ivanovsky Institute of Virology, Federal State Budgetary Institution «N.F.Gamaleya FRCEM» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
E. V. Kazennova
D.I.Ivanovsky Institute of Virology, Federal State Budgetary Institution «N.F.Gamaleya FRCEM» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
K. B. Gromov
D.I.Ivanovsky Institute of Virology, Federal State Budgetary Institution «N.F.Gamaleya FRCEM» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
E. A. Lomakina
Sakhalin Regional AIDS Center
Russian Federation
Russian Federation
E. Yu. Zozylya
Sakhalin Regional AIDS Center
Russian Federation
Russian Federation
P. G. Bersenev
Sakhalin Regional AIDS Center
Russian Federation
Russian Federation
M. R. Bobkova
D.I.Ivanovsky Institute of Virology, Federal State Budgetary Institution «N.F.Gamaleya FRCEM» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Tumanov A.S., Kazennova E.V., Gromov K.B., Lomakina E.A., Zozylya E.Yu., Bersenev P.G., Bobkova M.R. THE MOLECULAR EPIDEMIOLOGICAL ANALYSIS OF HIV INFECTION IN SAKHALIN REGION, RUSSIA. HIV Infection and Immunosuppressive Disorders. 2017;9(3):113-120. (In Russ.) https://doi.org/10.22328/2077-9828-2017-9-3-113-120
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