THE CONTROL SYSTEM OF HIV INFECTION. PART 1. PRINCIPLES OF OPERATION AND OPTIMAL PARAMETERS

Aim: to conduct an analysis of the HIV infection management system adopted in the Russian Federation, to formulate the basic principles of optimization of this model for epidemiological and economic indicators. Materials and methods: the methods of system analysis were used in the work. The decomposition of the existing HIV management system into structural components made it possible to identify the most informative data collected in the standard Center of AIDS prevention. The optimal criteria for the management of the epidemic process of HIV infection have been determined, and functional links have been established between the parameters necessary to increase the efficiency available in the practical healthcare system. Results: the data with information sufficiency (sex, age, etc.) and redundancy (social groups, contingents of the surveyed population) were identified. The main principle of optimization of the HIV management system is formulated: to distribute the available financial resources, personnel, material resources between screening, treatment activities and preventive work in such a way that the rate of growth of new cases of infection is maximally close to zero (for a given level of funding). To develop such a system requires a mathematical model of the epidemic process. The principle of developing such a model: the use of data available in practical public health services, the possibility of adaptation to any territory with certain epidemiological features. The output should be the calculation of the optimal distribution of available financial resources, the forecast for the development of the epidemic in this distribution and the determination of the minimum amount necessary, at which the rate of epidemic development will acquire a negative trend. The structure of such a model, the required parameters and methods of mathematical modeling are described. 

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