CORONAVIRUS INFECTIOUS DISEASE COVID-19. NATURE OF VIRUS, PATHOGENESIS, CLINICAL MANIFESTATIONS, REPORT 1
https://doi.org/10.22328/2077-9828-2020-12-1-7-21
Abstract
In this number, we begin publication of case series devoted to epidemiology, clinical picture, diagnosis, treatment, prevention, medical and social consequences of COVID-19. Taking into account the situation anxiety, infection scope and spread rate, involvement of the whole nation into the problem irrespective of gender, age, social affiliations along with comprehensive observing social and medical prevention measures, preemptive training and continuing education of medical specialists are essential considering that novel coronavirus is new not only viewed from its molecular biological features perspective but also from the perspective of possible difficulties of diagnosis and treatment, clinical features, high risk of development of critical con- ditions and complications, high mortality rate that has been shown by an example of China, USA, and European Countries.
In the first report, we tried to highlight the experience gained in the study of novel coronavirus nature, epidemiology, pathogenesis and clinical manifestations, give information from literature sources based on the experience of our colleagues in coping with serious disease and its consequences.
About the Authors
N. A. Belyakov
First St. Petersburg State Medical University named after I.P. Pavlov; Institute of Experimental Medicine RAS; St. Petersburg Pasteur Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
V. V. Rassokhin
First St. Petersburg State Medical University named after I.P. Pavlov; Institute of Experimental Medicine RAS; St. Petersburg Pasteur Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
E. B. Yastrebova
First St. Petersburg State Medical University named after I.P. Pavlov; St. Petersburg Pasteur Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
References
1. CDC. 2019 Novel Coronavirus, Wuhan, China. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/about/index.html. January 26, 2020; Accessed: January 27, 2020.
2. Gallegos A. WHO Declares Public Health Emergency for Novel Coronavirus // Medscape Medical News. Available at https://www.medscape.com/viewarticle/924596. January 30, 2020; Accessed: January 31, 2020.
3. Ramzy А., McNeil D.G. W.H.O. Declares Global Emergency as Wuhan Coronavirus Spreads // The New York Times. Available at https://nyti.ms/2RER70M. January 30, 2020; Accessed: January 30, 2020.
4. The New York Times. Coronavirus Live Updates: W.H.O. Declares Pandemic as Number of Infected Countries Grows // The New York Times. Available at https://www.nytimes.com/2020/03/11/world/coronavirus-news.html#link-682e5b06. March 11, 2020; Accessed: March 11, 2020.
5. https://www.who.int/emergencies/diseases/novel-coronavirus-2019.
6. Coronavirus Updates: The Illness Now Has a Name: COVID-19 // The New York Times. Available at https://www.nytimes.com/2020/02/11/world/asia/coronavirus-china.html. February 11, 2020; Accessed: February 11, 2020.
7. WHO Director-General’s remarks at the media briefing on 2019-nCoV on 11 February 2020. Available at https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020. February 11, 2020; Accessed: February 13, 2020.
8. Gorbalenya A.E. Severe acute respiratory syndrome-related coronavirus — The species and its viruses, a statement of the Coronavirus Study Group. Available at https://doi.org/10.1101/2020.02.07.937862. February 11, 2020; Accessed: February 13, 2020.
9. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report — 48. World Health Organization. Available at https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200308-sitrep-48-covid-19.pdf?sfvrsn=16f7ccef_4. March 8, 2020; Accessed: March 9, 2020.
10. CDC. 2019 Novel Coronavirus, Wuhan, China: 2019 Novel Coronavirus (2019-nCoV) in the U.S. Centers for Disease Control and Prevention (CDC). Available at https://www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html. March 18, 2020; Accessed: March 19, 2020.
11. Otto M.A. Wuhan Virus: What Clinicians Need to Know. Medscape Medical News. Available at https://www.medscape.com/viewarticle/924268. January 27, 2020; Accessed: January 27, 2020.
12. Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) — United States, February 12–March 16, 2020. MMWR Morb. Mortal. Wkly Rep. 2020. Mar. 18. Р. 69 [Full Text].
13. Bernstein L., McGinley L., Sun L.H. Northern California coronavirus patient wasn’t tested for days. The Washington Post. Available at https://www.washingtonpost.com/health/northern-californian-tests-positive-for-coronavirus-in-first-us-case-with-no-link-to-foreigntravel/2020/02/26/b2088840–58fb-11ea-9000-f3cffee23036_story.html. February 27, 2020; Accessed: February 27, 2020.
14. CDC. Coronavirus Disease 2019 (COVID-19): COVID-19 Situation Summary. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/summary.html. February 29, 2020; Accessed: March 2, 2020.
15. https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6.
16. Brunk D. CDC: First Person-to-Person Spread of Novel Coronavirus in US. Medscape Medical News. Available at https://www.medscape.com/viewarticle/924571. January 30, 2020; Accessed: January 31, 2020.
17. U.S. reports its first case of person-to-person transmission. The New York Times. Available at https://www.nytimes.com/2020/01/30/world/asia/coronavirus-china.html#link-69c13d84. January 30, 2020; Accessed: January 30, 2020.
18. Centers for Disease Control and Prevention. Coronavirus Disease 2019 (COVID-19): People at Higher Risk. Centers for Disease Control andPrevention. Available at https://www.cdc.gov/coronavirus/2019-ncov/specific-groups/high-risk-complications.html. March 8, 2020; Accessed:March 9, 2020.
19. CDC. 2019 Novel Coronavirus, Wuhan, China: Frequently Asked Questions and Answers. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/faq.html. January 27, 2020; Accessed: January 27, 2020.
20. Wei M., Yuan J., Liu Y., Fu T., Yu X., Zhang Z.J. Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China // JAMA.2020. Feb 14. [Medline].
21. Bai Y., Yao L., Wei Т., Tian F., Jin D.Y., Chen L. et al. Presumed Asymptomatic Carrier Transmission of COVID-19 // JAMA. 2020. Feb. 21. [Medline].
22. Yu P, Zhu J., Zhang Z., Han Y., Huang L. A familial cluster of infection associated with the 2019 novel coronavirus indicating potential personto-person transmission during the incubation period // J. Infect. Dis. 2020. Feb. 18. [Medline].
23. Zou L., Ruan F., Huang M., Liang L., Huang H., Hong Z. et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients // N. Engl. J. Med. 2020. Feb. 19. [Medline].
24. Li Q., Guan X., Wu Р., Wang X. et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia // N. Engl. J. Med. 2020. Jan. 29. [Medline].
25. CDC. 2019 Novel Coronavirus, Wuhan, China: How it Spreads. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/about/transmission. html. January 26, 2020; Accessed: January 27, 2020.
26. Ashlock P.D. Monophyly and Associated Terms // Systematic Zoology. 1971. Vol. 20 (1). Р. 63–69.
27. Abutaleb Y. How the new coronavirus differs from SARS, measles and Ebola // The Washington Post. Available at https://www.washingtonpost.com/health/how-the-new-coronavirus-differs-from-sars-measles-and-ebola/2020/01/23/aac6bb06-3e1b-11ea-b90d-5652806c3b3a_story.html. January 23, 2020; Accessed: January 27, 2020.
28. Hui D.S., Azhar I.E., Madani T.A., Ntoumi F., Kock R., Dar O. et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China // Int. J. Infect. Dis. 2020. Jan. 14. Vol. 91. Р. 264–266. [Medline].
29. https://bloximages.chicago2.vip.townnews.com/mtstandard.com/content/tncms/assets/v3/editorial/3/09/309413f8-18f0-5da9-8061-18ad4073fa82/5e6c344bd6be3.preview.jpg?crop=1301%2C732%2C0%2C430&resize=1120%2C630&order=crop%2Cresize
30. https://www.bloomberg.com/news/articles/2020-01-31/here-are-the-first-images-of-how-coronavirus-replicates-in-cells
31. Bobkova M.R. Biology of HIV. Human Immunodeficiency Virus —Medicine / eds. N.A.Belyakov, A.G.Rakhmanova. St. Petersburg: Baltic Medical Education Center, 2010, рр. 17–70 (In Russ.).
32. Wan Y., Shang J., Graham R., Baric R.S., Li F. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS // J. Virology. 2020 (published online Jan 29.). doi: 10.1128/JVI.00127-20.
33. Li X.C., Zhang J., Zhuo J.L. The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases // Pharmacol Res. 2017. Vol. 125. Р. 21–38.
34. Simbirtsev S.A., Belyakov N.A. Microembolism of the lungs. Leningrad: Medicine, 1986, 216 p. (In Russ.).
35. Korovin A.E., Novitsky A.A., Makarov D.A. Acute respiratory distress syndrome. The current state of the problem. Clinical pathophysiology, 2018, Vol. 24, No. 2, рp. 32–41 (In Russ.).
36. Galkin A.A., Demidova V.S. The central role of neutrophils in the pathogenesis of acute lung injury syndrome (acute respiratory distress syndrome). Successes of modern biology, 2014, Vol. 134, No. 4, рр. 377–394 (In Russ.).
37. https://myslide.ru/documents_4/b754f0eb7260ca333aaa5b04c1496053/img14.jpg. (дата обращения; 04.04.2020)
38. https://yandex.ru/images/search?from=tabbar&text=электронная%20микроскопия%20ткани%20легкого%20при%20covid&p=14&pos=434&rpt=simage&img_url=https%3A%2F%2Fupload.wikimedia.org%2Fwikipedia%2Fcommons%2Fthumb%2F3%2F34%2FMERS_Coronavirus_Particles.jpg%2F476px-MERS_Coronavirus_Particles.jpg. (дата обращения; 04.04.2020).
39. https://upload.wikimedia.org/wikipedia/commons/5/5a/Hyaline_membranes_-_high_mag.jpg. (дата обращения: 04.04.2020).
40. Svetlitskaya O.I., Sirosh Yu.A., Blatun V.P., Kanus I.I. The risk of developing acute respiratory distress syndrome in patients with community-acquired viral-bacterial pneumonia. Emergency medicine, 2018, Vol. 7, N.o 4, рp. 564–569 (In Russ.).
41. Avdeev S.N. Pneumonia and acute respiratory distress syndrome caused by influenza A/H1N1 virus. Pulmonology. Application, 2010, No. 1, рp. 32–46 (In Russ.).
42. Bilichenko T.N., Chuchalin A.G. Morbidity and mortality of the Russian population from acute respiratory viral infections, pneumonia and vaccination. Therapeutic Archive, 2018, Vol. 90, No 1, рp. 22–26 (In Russ.).
43. Chuchalin A.G., Sinopalnikov A.I., Kozlov R.S. Clinical recommendations for the diagnosis, treatment and prevention of severe communityacquired pneumonia in adults. Clinical microbiology and antimicrobial chemotherapy, 2015, Vol. 17, No 2, рp. 84–126 (In Russ.).
44. Huang C, Wang Y., Li X., Ren L., Zhao J., Hu Y. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China // Lancet. 2020. Jan. 24. [Medline].
45. Chan J.F., Yuan S., Kok K.H., To K.K., Chu H., Yang J. et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster // Lancet. 2020. Jan 24. [Medline].
46. CDC. 2019 Novel Coronavirus, Wuhan, China: Symptoms. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/about/symptoms.html. January 26, 2020; Accessed: January 27, 2020. (дата обращения: 07.04.2020).
47. Lauer S.A., Grantz K.H., Bi Q., Jones F.K., Zheng Q., Meredith H.R. et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application // Ann. Intern. Med. 2020 Mar 10. [Medline].
48. Wu Z., McGoogan J.M. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases from the Chinese Center for Disease Control and Prevention. // JAMA. 2020. Feb. 24. [Medline].
49. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). Available at http://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf. February 16–24, 2020; Accessed: March 04, 2020.
50. Zhou F., Yu Т., Du R, Fan G, Liu Y., Liu Z. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China:a retrospective cohort study // Lancet. 2020. Mar. 11. [Medline].
51. Nicoletti B. Coding for Coronavirus: NEW Guidance Replaces the Rule of 1 Month Ago // Medscape. 2020. Mar. 30. https://www.medscape.com/viewarticle/927633?nlid=134829_2049&src=WNL_mdplsnews_200403_mscpedit_imed&uac=344220ST&spon=18&impID=2334280&faf=1.
52. https://meduniver.com/Medical/Microbiology/klinika_covid19.html MedUniver. (дата обращения: 06.04.2020)
53. Guan W.J., Ni Z.Y., Hu Y. et al. Clinical Characteristics of Coronavirus Disease 2019 in China // N. Engl. J. Med. 2020. Feb. 28 [Medline].
54. Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y. et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study // Lancet. 2020. Feb 15. Vol. 395 (10223). Р. 507–513 [Medline].
55. Wang D., Hu B., Hu C., Zhu F., Liu X., Zhang J. et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China // JAMA. 2020. Feb. 7. [Medline].
56. Wu C., Chen X., Cai Y., Xia J., Zhou X., Xu S. et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China // JAMA Intern. Med. 2020. Mar. 13. [Medline].
57. https://jamanetwork.com/journals/jama/pages/coronavirus-alert. (дата обращения: 06.04.2020)
58. Pan L. et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study // The American Journal of Gastroenterology. 10.14309/ajg.0000000000000620.
59. Wei M., Yuan J., Liu Y., Fu Т., Yu X., Zhang Z.J. Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China. JAMA. 2020 Feb 14. [Medline].
60. Lu X., Zhang L., Du H. et al. SARS-CoV-2 Infection in children // N. Engl. J. Med. 2020. Mar. 18. doi: 10.1056/NEJMc2005073.
61. Xia W, Shao J., Guo Y. et al. Clinical and CT features in pediatric patients with COVID‐19 infection: Different points from adults // Pediatr. Pulmonol. Published online March 5, 2020. https://onlinelibrary.wiley.com/doi/full/10.1002/ppul.24718. Accessed March 27, 2020. Article full text.
62. Guo Т., Yongzhen F., Chen М., Wu Х., Zhang L., He Т., Wang H., Wan J., Wang Х., Lu Z. Cardiovascular Implications of Fatal Outcomes of Patients with Coronavirus Disease 2019 (COVID-19) // JAMA Cardiol. doi: 10.1001/jamacardio.2020.1017 Published online March 27, 2020
63. Dong Y., Mo X., Hu Y. et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics. Published online March 16. https://pediatrics.aappublications.or text. (дата обращения: 07.04.2020).
Review
For citations:
Belyakov N.A., Rassokhin V.V., Yastrebova E.B. CORONAVIRUS INFECTIOUS DISEASE COVID-19. NATURE OF VIRUS, PATHOGENESIS, CLINICAL MANIFESTATIONS, REPORT 1. HIV Infection and Immunosuppressive Disorders. 2020;12(1):7-21. (In Russ.) https://doi.org/10.22328/2077-9828-2020-12-1-7-21
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