Ultrasonic disintegration of circulating immune complexes is a clinical innovation laboratory diagnostics of infectious diseases
https://doi.org/10.22328/2077-9828-2021-13-4-90-95
Abstract
Data describing the effects of ultrasound upon blood serum biological objects are analyzed in the paper. Biophysical as well as medical aspects of tissue reactions caused by ultrasound are considered in fine detail including the immune complexes’ dissociation processes accompanied by releasing of antibodies and antigens that used to be present in bound form and have been inaccessible for revelation using laboratory tests. The prospects of using ultrasonic techniques in laboratory diagnostics are presented using HIV infection as an example.
About the Authors
V. L. Pastushenkov
Sevastopol State University; Joint Stock Company «LOMO»
Russian Federation
Russian Federation
Sevastopol
St. Petersburg
Yu. A. Mitin
S. M. Kirov Military Medical Academy
Russian Federation
Russian Federation
St. Petersburg
S. Yu. Dudnikov
Sevastopol State University; Joint Stock Company «LOMO»
Russian Federation
Russian Federation
Sevastopol
St. Petersburg
K. V. Shedova
I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
St. Petersburg
D. E. Valutite
St. Petersburg Scientific Research Institute of Epidemiology and Microbiology named after Pasteur
Russian Federation
Russian Federation
St. Petersburg
T. S. Emanuel
A. I. Herzen Russian State Pedagogical University
Russian Federation
Russian Federation
St. Petersburg
References
1. Belyakov N.A. Immunodeficiency Virus-a danger to humans Saint Petersburg University for the Humanities of trade unions. Saint Petersburg, 2020. Ser. 206 Selected lectures of the University (In Russ.).
2. Pokrovsky V.V. HIV infection and AIDS / ed. 2nd ed., reprint and additional. Moscow: Publishing house GEOTAR-Media, 2010, 192 р. (In Russ.).
3. Ochsenbein A.F., Zinkernagel R.M. Natural antibodies and complement link innate and acquired immunity // Immunol. Today. 2000. Vol. 21, P. 624–630.
4. Ochsenbein A.F. et al. Correlation of T cell independence of antibody responses with antigen dose reaching secondary lymphoid organs: implications for splenectomized patients and vaccine design // J. Immunol. 2000. Vol. 164. P. 6296–6302.
5. Kopf M., Abel B., Gallimore A., Carroll M., Bachmann M.F. Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection // Nature Med. 2002. Vol. 8. P. 373–378.
6. Bartlett J., Gallant J., Pham P. Clinical aspects of HIV infection. Moscow: Publishing house R. Valent, 2012, 528 р. (In Russ.).
7. Douek D.C., Roederer M., Koup R.A. Emerging concepts in the immunopathogenesis of AIDS // Ann. Rev. Med. 2009. Vol. 60. P. 471–484.
8. Liu P., Overman G.R., Yates N.L. // J. Virol. 2011. Vol. 85. P. 11196–11207.
9. Lisitsyna Z.N., Dmitrievskaya K.A., Koroban N.V., Kondrashova T.V. Immune tests and diagnostics of the acute stage of HIV infection. HIV infection and immunosuppression, 2017, Vol. 9, No. 2, рр. 36–41 (In Russ.).
10. Fiscus S.A., Folds J.D., van der Horst C.M. Infectious immune complexes in HIV-1-infected patients // Viral. Immunol. 1993. Vol. 6. P. 135–141.
11. Krapf F.E., Herrman M., Leitmann W. et al. Circulating immune complexes in HIV-infected persons // Klin. Wochenschr. 1990. Vol. 68. P. 299–305.
12. Jefferis R., Kumararatne D.S. Selective IgG subclass deficiency: quantification and clinical relevance // Clin. and Exp. Immunol. 1990. Vol. 81. P. 357–367.
13. Korolevskaya L.B., Shmagel K.V., Shmagel N.G. Characteristics of circulating immune complexes in HIV-infected patients with different levels of viral load. Bulletin of experimental biology and medicine, 2015, Vol. 159, No. 4, рp. 460–463 (In Russ.).
14. Galiullin N.I., Nagimova F.I., Semenova L.V., Koksin V.P. Study of the spectrum of HIV proteins in circulating immune complexes of blood serum in HIV infection // Current issues of HIV infection. Materials of the International scientific and practical conference, 2019, рp. 241–242 (In Russ.).
15. Ryazanova G.A., Koksin V.P., Khamzina R.V. «Free» and «bound» antibodies to HIV-1 structural proteins in the early period of the disease. Medical immunology, 2005, Vol. 7, No. 1, рp. 73–76 (In Russ.).
16. Saprygin D.B., Ivanov A.M. Laboratory diagnostics of infectious diseases. Directory. Мoscow, 2016, 648 р. (In Russ.).
17. Finogeev Yu.P., Lobzin Yu.V., Zakharenko S.M. et al. Clinical and laboratory diagnostics of infectious diseases. A guide for physicians. St. Petersburg, 2001, 384 р. (In Russ.].
18. Mazus A.I. et al. National clinical guidelines for the diagnosis and treatment of HIV infection in adults. Мoscow, 2014, 75 р. (In Russ.).
19. Mitin Yu.A., Pastushenkov V.L, Emanuel V.L., Gabaeva M.M. Biophysical modulation as a technological stage of in vitro studies of the biochemical composition of biological objects // HIV Infection and Immunosuppressive Disorders. 2021. Vol. 13, No. 3. P. 134–138. http://dx.doi.org/10.22328/2077-9828-2021-13-3-134-138.
Review
For citations:
Pastushenkov V.L., Mitin Yu.A., Dudnikov S.Yu., Shedova K.V., Valutite D.E., Emanuel T.S. Ultrasonic disintegration of circulating immune complexes is a clinical innovation laboratory diagnostics of infectious diseases. HIV Infection and Immunosuppressive Disorders. 2021;13(4):90-95. (In Russ.) https://doi.org/10.22328/2077-9828-2021-13-4-90-95
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