Course of COVID-19 in patients with HIV infection and morphological changes in the lungs with a combined damage SARS-CoV2 and secondary infections
https://doi.org/10.22328/2077-9828-2022-14-1-107-114
Abstract
The purpose statement is to study the course of COVID-19 in patients with HIV infection and morphological changes in the lungs with their combined SARS-CoV-2 and secondary infections.
Materials and methods: The study included 96 patients with HIV infection and SARS-CoV-2 infection confirmed by PCR, aged 26 to 54 years. The clinical manifestations, the content of CD4-lymphocytes and HIV RNA, the presence of secondary infections, and morphological changes in the lungs were studied.
Results and discussion: In patients with HIV infection with moderate or severe immunodeficiency, a mild course of COVID19 (63.2%) was observed more often than in patients without immunodeficiency (14.3%). Four out of 9 patients with severe immunodeficiency developed a combined lesion of the lung tissue (SARS-CoV-2 + CMV and SARS-CoV-2 + Pneumocystis carinii) with a fatal outcome.
Conclusion: In the diagnosis and treatment of COVID-19 in patients with HIV infection, it is necessary to take into account the severity of immunodeficiency and viral load.
About the Authors
D. V. Kapustin
Novosibirsk State Medical University;
City Infectious Diseases Clinical Hospital No. 1
Russian Federation
Russian Federation
Novosibirsk
E. I. Krasnova
Novosibirsk State Medical University;
City Infectious Diseases Clinical Hospital No. 1
Russian Federation
Russian Federation
Novosibirsk
N. I. Khokhlova
Novosibirsk State Medical University;
City Infectious Diseases Clinical Hospital No. 1
Russian Federation
Russian Federation
Novosibirsk
O. M. Shishkova
City Infectious Diseases Clinical Hospital No. 1
Russian Federation
Russian Federation
Novosibirsk
Ya. S. Ulyanova
Novosibirsk State Medical University;
City Infectious Diseases Clinical Hospital No. 1
Russian Federation
Russian Federation
Novosibirsk
A. I. Tyryshkin
Novosibirsk State Medical University
Russian Federation
Russian Federation
Novosibirsk
References
1. Chu D.K., Akl E.A., Duda S., Solo К. et al. Physical distancing, face masks, and eye protection to prevent person to person transmission of SARSCoV-2 and COVID-19: a systematic review and meta analysis // J. Vasc. Surg. 2020. Vol. 72, No. 4. Р. 1500.
2. Guo Z.D., Wang Z.Y., Zhang S.F. et al. Aerosol and surface distribution of severe acute respiratory syndrome coronavirus 2 in hospital wards. Wuhan, China, 2020 // Emerg. Infect. Dis. 2020. Vol. 26, No. 7. Р. 1586–1591.
3. Hegedus A., Williamson К.M., Huthoff H. HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T-cells // Retrovirology. 2014. Vol. 11. Р. 98.
4. Lee K.W., Yap S.F., Ngeow Y., Munn L.S. COVID 19 in People Living with HIV: A Systematic Review and Meta Analysis // International Journal of Environmental Research and Public Health. 2021. Vol. 18. Р. 3554. 10.3390/ijerph18073554.
5. Velasco M. Incidence and Severity of COVID-19 in HIV-Positive Persons Receiving Antiretroviral Therapy // Annals of internal medicine. 2020. Vol. 173, No. 7. Р. 536–541.
Review
For citations:
Kapustin D.V., Krasnova E.I., Khokhlova N.I., Shishkova O.M., Ulyanova Ya.S., Tyryshkin A.I. Course of COVID-19 in patients with HIV infection and morphological changes in the lungs with a combined damage SARS-CoV2 and secondary infections. HIV Infection and Immunosuppressive Disorders. 2022;14(1):107-114. (In Russ.) https://doi.org/10.22328/2077-9828-2022-14-1-107-114
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