IFN-γ/IL-10 ratio as an indicator of treatment effectiveness in patients with pulmonary tuberculosis

The aim: was to investigate the dynamics of the IFN-γ/IL-10 ratio during the intensive phase of chemotherapy in patients with pulmonary tuberculosis.

Materials and methods. The study group is represented by 100 patients suffering from pulmonary tuberculosis (newly diagnosed pulmonary tuberculosis — 60 people, chronic pulmonary tuberculosis — 40 people). Serum cytokine concentrations were determined by enzyme-linked immunosorbent assay.

Results and discussion. It was found that in the case of the «effective» intensive phase of chemotherapy in patients with pulmonary tuberculosis, the ratio IFN-γ/IL-10 tended to increase from 0.183±0,01 to 0.233±0,02, and in the case of the «ineffective» phase of chemotherapy, this ratio tended to decrease from 0.3±0,015 to 0.2±0,011.

Conclusion. The ratio of IFN-γ/IL-10 during the intensive phase of chemotherapy in patients with pulmonary tuberculosis can be used as an additional marker of the effectiveness of chemotherapy in patients with pulmonary tuberculosis.

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