PREGNANCY COURSE VARIANTS, PERINATAL OUTCOMES, AND THE RESULTS OF THERAPY FOR TUBERCULOSIS DURING THE ANTENATAL PERIOD IN WOMEN COINFECTED WITH HIV AND TB

Abstract

The characteristics of pregnancy and parturition, the perinatal outcomes, and the results of therapy for tuberculosis were analyzed based on findings related to 24 women coinfected with HIV and TB who were followed up at Krasnoyarsk Regional TB Dispensary № 1 in 2010-2014. Eight women continued psychoactive drug abuse during pregnancy. Abortions were made upon patient’s agreement with medical panel advice in four cases of seven associated with the progression of coinfection during the second trimester. Pregnancy ended with parturition in 13 cases. One infant died within the antenatal period. Among twelve mother-and-child pairs, eight passed through three-stage preventive interventions against perinatal HIV transmission. One infant still contracted the coinfection and died of it at six months of age. Three women died, including two cases that occurred in the early postpartum period and one case that occurred in 20 months, its causes being unrelated to TB or HIV Radiological examinations revealed TB progression during the early and late postpartum period in seven and four women, respectively. With account of forced combined therapy and resulting multiple drug interactions and of high risks of adverse outcomes for both, women and fetuses, HIV-infected women coinfected with TB should be strongly advised to use contraception.