THE USE OF INTRAVENOUS IMMUNOGLOBULINS IN PATIENTS WITH HIV-ASSOCIATED NEUROLOGICAL DISORDERS: Literature review and case report of HIV-associated myelopathy
https://doi.org/10.22328/2077-9828-2016-8-3-91-100
Abstract
The clinical manifestations of lesions of the nervous system found at different stages of HIV infection in most patients may be caused by compromised cell immunity, direct neurotoxic effects of HIV, and pathological immune responses. Despite of significant progress in therapy for HIV-associated neurological disorders since the highly active antiretroviral therapy had been introduced into clinical practice, the problem of drugs able to eradicate HIV and to influence autoimmune processes is still urgent. Therapeutic means rendering complex anti-infection and immunoregulatory effects include intravenous immunoglobulin administration (IIA), which can improve prognosis significantly in some cases of HIV-associated neurological disorders. The present paper briefly reviews literature about diagnostics and treatment of nervous system lesions in HIV patients. A case of HIV-associated myelopathy progression in a HAART-treated patient is considered in detail. Diagnostic algorithms and possible mechanisms of IIA effects in cases of HIV-associated neurological disorders are discussed.
About the Authors
L. N. Prakhova
N.PBechtereva Institute of Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. G. Ilves
N.PBechtereva Institute of Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Z. I. Savintceva
N.PBechtereva Institute of Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. S. Parfenova
N.PBechtereva Institute of Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
S. N. Kizhlo
Saint-Petersburg Center for Control of AIDS and Infectious Diseases
Russian Federation
Russian Federation
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Review
For citations:
Prakhova L.N., Ilves A.G., Savintceva Z.I., Parfenova A.S., Kizhlo S.N. THE USE OF INTRAVENOUS IMMUNOGLOBULINS IN PATIENTS WITH HIV-ASSOCIATED NEUROLOGICAL DISORDERS: Literature review and case report of HIV-associated myelopathy. HIV Infection and Immunosuppressive Disorders. 2016;8(3):91-100. (In Russ.) https://doi.org/10.22328/2077-9828-2016-8-3-91-100
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