HYPOTHALAMUS-PITUITARY-ADRENAL SYSTEM CONDITION IN HIV INFECTION
https://doi.org/10.22328/2077-9828-2014-6-2-41-48
Abstract
HIV infection is often accompanied by disorders in the hypothalamus-pituitary-adrenal system. Its dysfunctions at the early stages of the disease are manifested as increased blood cortisol, which is believed to be caused by increased cytokines able to enhance glucocorticoids production. With the further progression of HIV infection, the risk of adrenal failure increases because of opportunistic infections (most commonly cytomegaloviral) or neoplastic infiltration of adrenals and/or pituitary. Drugs used to treat HIV can also promote adrenal failure. For the differential diagnostics of the overt adrenal failure and conditions reminiscent of adrenal failure and for assessing the reserve capacity of adrenals, diagnostic test are expedient because unjustified therapy with glucocorticoids is unsafe.
About the Authors
D. M. Surzhenko
Saint-Petersburg Center for Control of AIDS and Infectious Diseases; I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry
Russian Federation
Russian Federation
V. V. Kuzik
I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry
Russian Federation
Russian Federation
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Review
For citations:
Surzhenko D.M., Kuzik V.V. HYPOTHALAMUS-PITUITARY-ADRENAL SYSTEM CONDITION IN HIV INFECTION. HIV Infection and Immunosuppressive Disorders. 2014;6(2):41-48. (In Russ.) https://doi.org/10.22328/2077-9828-2014-6-2-41-48
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