MODELS OF EARLY VERIFICATION OF DRUG RESISTANCE IN PATIENTS WITH HIV ON THE BASIS OF IMMUNOLOGICAL INDICES
https://doi.org/10.22328/2077-9828-2018-10-1-54-62
Abstract
The aim of the study is to identify immunological markers that may be important to predict drug resistance of patients to HAART.
Materials and methods. Examined 53 patients with HIV infection, virological and immunological HAART failure. All patients underwent the study of drug resistance genotyping method, determined the levels of cytokines IL-2, IL-6, IL-16, IL-23, TNF-a, HIV viral load, CD4+ T-lymphocytes. For building hypotheses about the nature of the impact of drug resistance on the results of laboratory tests (CD4+ T-lymphocytes, HIV viral load and cytokines) used imaging technique in chart form of the scale, correlation analysis. To predict the patient’s risk of drug resistance built models based on decision tree and logistic regression.
Conclusion. On the basis of information criterion, Akaike, and the results of the analysis of the predictive capabilities of the model, were considered the best model to determine the presence of drug resistance on the basis of the level of IL-16.
About the Authors
B. I. Geltser
Far Eastern Federal University
School of Biomedicine
Russian Federation
Vladivostok,
Russian Federation
Vladivostok,
L. F. Sclar
Pacific State Мedical University
Russian Federation
Vladivostok,
Russian Federation
Vladivostok,
V. S. Eliseeva
Pacific State Мedical University
Russian Federation
Vladivostok,
Russian Federation
Vladivostok,
K. I. Shakhgeldyan
Far Eastern Federal University
School of Biomedicine
Vladivostok State University of Economics and Service
Russian Federation
Vladivostok,
Russian Federation
Vladivostok,
E. V. Markelova
Pacific State Мedical University
Russian Federation
Vladivostok,
Russian Federation
Vladivostok,
E. D. Yemtseva
Vladivostok State University of Economics and Service
Russian Federation
Vladivostok,
Russian Federation
Vladivostok,
S. N. Beniova
Far Eastern Federal University
School of Biomedicine
Russian Federation
Vladivostok
Russian Federation
Vladivostok
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For citations:
Geltser B.I., Sclar L.F., Eliseeva V.S., Shakhgeldyan K.I., Markelova E.V., Yemtseva E.D., Beniova S.N. MODELS OF EARLY VERIFICATION OF DRUG RESISTANCE IN PATIENTS WITH HIV ON THE BASIS OF IMMUNOLOGICAL INDICES. HIV Infection and Immunosuppressive Disorders. 2018;10(1):54-62. (In Russ.) https://doi.org/10.22328/2077-9828-2018-10-1-54-62
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