CLINICAL, AMNESTIC AND IMMUNOLOGICAL PARAMETERS IN HIV-INFECTED PATIENTS WITH GASTROENTEROLOGICAL DISEASES

Nowadays the relevance of questions of comorbidity of different pathologies, including HIV infection diseases of the digestive system. Structural and functional changes in HIV infection can occur in  various organs of the digestive system: mouth, esophagus, stomach, liver and in the intestine.

The aim of the study was to examine features of the social, epidemiologic, somatic and immune status in HIV infected patients  with gastroenterological diseases. Materials and methods. The study  involved 500 HIV infected patients consisting on the dispensary  account in the Center for the prevention and control of AIDS of the Tyumen region.

Results. Sex-age structure and epidemiological history among HIV  infected patients with gastrointestinal pathology did not differ  (p>0,05) of the total cohort of HIV infected Tyumen region —  predominance of males, middle-aged with intravenous by HIV  infection in the non-medical use of psychoactive substances. The  most common gastrointestinal abnormalities in HIV infection are  diseases of the gastroduodenal zone (68,2%) and diseases of the  bile ducts (31,8 per cent). Indicators CD4, CD8, and LN of HIV  infected to determine the diversity and severity of clinical symptoms resulting from lesions of the digestive tract. The prevalence of gastrointestinal disease in HIV infected patients had inverse  correlation of medium strength with immunoregulatory index  CD4/CD8  (r=-0,537; p<0,05).

Conclusion. Pathogenetic defeat of the digestive system in HIV infection may be caused by direct impact of the virus on the  gastrointestinal tract and opportunistic infections, and the indirect  influence during chronic systemic inflammatory response and immunodeficiency condition, and also result from prolonged administration of drugs.

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