AUTOCHTHONOUS CASE OF CUTANEOUS LEISHMANIASIS IN HIV INFECTED PATIENT
https://doi.org/10.22328/2077-9828-2019-11-1-75-80
Abstract
Single cases of autochthonous visceral leishmaniasis are registered in the Crimea and Dagestan. The article presents the first case of autochthonous cutaneous leishmaniasis in an HIV infected resident of the Republic of Dagestan, where this disease had not previously been registered. The diagnosis was made on the basis of a parasitological study of material taken from an ulcer on the border between the upper lip and the right nostril. Examination of the patient revealed a high burden of HIV (4 473 014 copies/ml) and a low level of CD4+ (76×106/l; 9%), which indicated an advanced stage of HIV infection. The patient underwent antiretroviral therapy (treatment with amphotericin B), against which a good result was obtained. A decrease in viral load and an increase in the content of CD4 lymphocytes in the blood were noted. A scar has formed on the site of a leishmaniasis ulcer.
About the Authors
L. A. Ermakova
Rostov Research Institute for Microbiology and Parasitology;
Rostov State Medical University Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
N. V. Golovchenko
Rostov Research Institute for Microbiology and Parasitology
Russian Federation
Russian Federation
S. A. Nagorny
Rostov Research Institute for Microbiology and Parasitology
Russian Federation
Russian Federation
N. Yu. Pshenichnaya
Rostov Research Institute for Microbiology and Parasitology;
Rostov State Medical University Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
L. A. Avanesova
Republican Center on Prevention and Control of AIDS Ministry of Health of the Republic of Daghestan
Russian Federation
Russian Federation
A. S. Zhuravlev
First Moscow State Medical University named after I.M.Sechenov Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
References
1. Giavedoni P., Iranzo P., Fuertes I., Estrach T., Alsina Gibert M. Cutaneous leishmaniasis: 20 years’ experience in a Spanish Tertiary Care Hospital. Actas Dermosifiliogr, 2015, Vol. 106, No. 4, pp. 310–316. URL: https://www.ncbi.nlm.nih.gov/pubmed/25678133.
2. Gradoni L., López-Vélez R., Mourad M. Manual on case management and surveillance of the leishmaniases in the WHO European region. World Health Organization, 2017.
3. About the situation of leishmaniasis in the Russian Federation. Letter of the Federal service for supervision of consumer rights protection and human welfare dated 04.03.2015 № 01/2160-15-27 (In Russ.)
4. Baranets M.S., Ermak T.N., Ponirovsky E.N. Clinical and epidemiological features of visceral leishmaniasis in the Republic of Crimea. Therapeutic Archive, 2017, Vol. 89, No. 11, pp. 100–104 (In Russ.)
5. Kabanova V.I., Basyuk E.M., Stepanova Ye.V., Zinserling V.A., Zyryanova Yu.O. Clinical case of visceral leishmaniasis in a patient with HIV infection. HIV Infection and Immunosuppressive Disorders, 2015, Vol. 7, No. 3, pp. 80–86 (In Russ.)
6. Alvar J., Aparicio P., Aseffa A., Den Boer M. et al. The relationship between leishmaniasis and AIDS: the second 10 years. Сlin. Microbiol. Rev., 2008, Vol. 21, No. 2, pp. 334–359.
7. Control of the leishmaniasis: report of a meeting of the WHO Expert Committee on the Control of Leishmaniases / WHO technical report series. Geneva: WHO, March 22–26, 2010, 186 р. URL: http://whqlibdoc.who.int/trs/WHO_TRS_949_eng.pdf (March 17, 2018).
8. Klintebjerg K., Petersen E., Pshenichnaya N.Y., Ermakova L.A. et al. Periorbital Dirofilaria repens imported to Denmark: A human case report. IDCases, 2015, Vol. 2, No. 1, pp. 25–26.
9. Petersen E., Chen L.H., Schlagenhauf-Lawlor P. Eds. Infectious Diseases: A Geographic Guide. 2nd. ed. John Wiley & Sons Ltd, 2017, 518 p.
10. Aslanov B.I., Pshenichnaya N.Y., Melnik V.A., Rakhmanova N. Promed-mail: internet-based surveillance system for emerging infectious diseases. Preventive and Clinical Medicine, 2017, No. 2 (63), pp. 54–59.
Review
For citations:
Ermakova L.A., Golovchenko N.V., Nagorny S.A., Pshenichnaya N.Yu., Avanesova L.A., Zhuravlev A.S. AUTOCHTHONOUS CASE OF CUTANEOUS LEISHMANIASIS IN HIV INFECTED PATIENT. HIV Infection and Immunosuppressive Disorders. 2019;11(1):75-80. (In Russ.) https://doi.org/10.22328/2077-9828-2019-11-1-75-80
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