HIV and infertility: neuro-endocrine and metabolic aspects
https://doi.org/10.22328/2077-9828-2020-12-4-73-80
Abstract
Objective: to establish a correlation of the main neuroendocrine and metabolic parameters associated with infertility and to provide a prognostic assessment of reproductive disorders in HIV-infected women, stages 4.
Materials and methods. Cross-sectional, cohort, clinical and sociological study of fertility of 83 women of reproductive age with HIV, stages 4.
Results. The most significant indicators of lipid peroxidation and neuroendocrine regulation systems have been established in patients with HIV infection and reproductive disorders, which will make it possible to predict these disorders in the future. Decreased ovarian reserve, ovarian steroid function, increased pituitary prolactinergic function are associated with a deficiency of a number of antioxidants (retinol, tocopherol, superoxide dismutase) and the development of oxidative stress with a predominant accumulation of intermediate lipid peroxidation products in HIV-infected women with infertility.
Conclusion. The pathogenetically substantiated principle of the correction of antioxidant status is the use of a-tocopherol and retinol preparations and the correction of hormonal levels in HIV-infected women with reproductive disorders.
Keywords
pregnancy,
infertility,
HIV infection,
hormones,
lipid peroxidation,
antioxidants,
reproduction,
fertility
About the Authors
O. Ya. Leshchenko
Scientific Centre of Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Olga Ya. Leshchenko
Irkutsk
E. V. Genich
Scientific Centre of Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Elena V. Genich
Irkutsk
M. A. Darenskaya
Scientific Centre of Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Maria A. Darenskaya
Irkutsk
L. I. Kolesnikova
Scientific Centre of Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Lyubov I. Kolesnikova
Irkutsk
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Review
For citations:
Leshchenko O.Ya., Genich E.V., Darenskaya M.A., Kolesnikova L.I. HIV and infertility: neuro-endocrine and metabolic aspects. HIV Infection and Immunosuppressive Disorders. 2020;12(4):73-80. (In Russ.) https://doi.org/10.22328/2077-9828-2020-12-4-73-80
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