Seborrheic dermatitis associated with HIV infection: new concepts and hypotheses
https://doi.org/10.22328/2077-9828-2020-12-4-98-107
Abstract
The review article summarizes information about seborrheic dermatitis associated with HIV infection. The article presents current literature data about etiology and pathogenesis of seborrheic dermatitis, as well as the features of the clinical manifestations of seborrheic dermatitis associated with HIV infection. This article contains new hypotheses and concepts about combination of these two diseases. The most important role in pathogenesis of seborrheic dermatitis is belong to the fungus Malassazeia, which uses lipids from the skin surface to produce unsaturated and saturated fatty acids. These fatty acids, being left in the individual’s skin, may induce an inflammatory response. At the same time, the total lipid concentration on the skin surface of HIV-positive and HIV-negative patients with seborrheic dermatitis was similar. However, it was reported about significant alterations in the lipid fractions of HIV-positive patients including a reduction in squalene and an increase in cholesterol and in cholesterol esters, which lead to hypercolonization of the skin with yeast-like fungi and their transition in the pathogenic micellar form. The authors present a clinical case, which is demonstrating a severe course of seborrheic dermatitis associated with HIV infection.
About the Authors
A. A. Khryanin
Novosibirsk State Medical University
Russian Federation
Russian Federation
Alexey A. Khryanin
Novosibirsk
M. V. Russkikh
Novosibirsk State Medical University
Russian Federation
Russian Federation
Maria V. Russkikh
Novosibirsk
V. K. Bocharova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Valentina K. Bocharova
Novosibirsk
A. P. Nadeev
Novosibirsk State Medical University
Russian Federation
Russian Federation
Alexandr P. Nadeev
Novosibirsk
References
1. Parish L.C. L-dopa for seborrheic dermatitis // N. Engl J. Med. 1970. Vol. 283. 879 р.
2. Tronnier H. On an unilaterally localized seborrhoic eczema in syringomyelia // Z. Haut Geschlechtskr. 1964. Vol. 37. Р. 207–217.
3. Bettley F.R., Marten R.H. Unilateral seborrheic dermatitis following a nerve lesion // AMA Arch. Derm. 1956. Vol. 73. Р. 110–115.
4. Daneshpazhooh M., Nazemi T.M., Bigdeloo L., Yoosefi M. Mucocutaneous findings in 100 children with Down syndrome // Pediatr. Dermatol. 2007. Vol. 24. Р. 317–320.
5. Tager A., Berlin C., Schen R.J. Seborrhoeic Dermatitis in Acute Cardiac Disease // Br. J. Dermatol. 1964. Vol. 76. Р. 367–369.
6. Parish L.C., Fine E. Alcoholism and skin disease // Int. J. Dermatol. 1985. Vol. 24. Р. 300–301.
7. Kosmetsevitika in external therapy of seborrheic dermatitis. A.V. Sukhov, M.V. Goryachkina. Clinical Dermatology and Venereology, 2012, Vol. 10 (1), рр. 56–61 (In Russ.).
8. Schechtman R.C., Midgley G., Hay R.J. HIV disease and Malassezia yeasts: a quantitative study of patients presenting with seborrhoeic dermatitis // Br. J. Dermatol. 1995. Vol. 133. Р. 694–698.
9. Wolf C., Goldsmith L.A., Katz S.I., Gilcrest B.A., Paller E.S., Leffel D.J. Fitzpatrick Dermatology in Clinical Practice, 2012, Vol. 1, 868 pp. (In Russ.).
10. Wishner A.J., Teplitz E.D., Goodman D.S. Pityrosporum, ketoconazole, and seborrheic dermatitis // J. Am. Acad. Dermatol. 1987. Vol. 17. Р. 140–141.
11. Aspiroz M.C., Moreno L.A., Rubio M.C. Taxonomy of Malassezia furfur: state of the art // Rev. Iberoam. Micol. 1997. Vol. 14. Р. 147–149.
12. Faergemann J. Pityrosporum infections // J. Am. Acad. Dermatol. 1994. Vol. 31. S18–20.
13. Faergemann J. Pityrosporum ovale and skin diseases // Keio J. Med. 1993. Vol. 42. Р. 91–94.
14. Terui T., Kudo K., Tagami H. Cutaneous immune and inflammatory reactions to Malassezia furfur // Nihon Ishinkin Gakkai Zasshi. 1999. Vol. 40. Р. 63–67.
15. Faergemann J., Fredriksson T. Tinea versicolor with regard to seborrheic dermatitis. An epidemiological investigation // Arch. Dermatol. 1979. Vol. 115. Р. 966–968.
16. Faergemann J. Tinea versicolor and Pityrosporum orbiculare: mycological investigations, experimental infections and epidemiological surveys // Acta Derm Venereol Suppl. (Stockh.). 1979. Р. 1–23.
17. Bergbrant I.M., Faergemann J. Seborrhoeic dermatitis and Pityrosporum ovale: a cultural and immunological study // Acta Derm. Venereol. 1989. Vol. 69. Р. 332–335.
18. Nakabayashi A., Sei Y, Guillot J. Identification of Malassezia species isolated from patients with seborrhoeic dermatitis, atopic dermatitis, pityriasis versicolor and normal subjects // Med. Mycol. 2000. Vol. 38. Р. 337–341.
19. Nakabayashi A. Identification of causative species in malassezia-associated dermatoses // Nihon Ishinkin Gakkai Zasshi. 2002. Vol. 43. Р. 65–68.
20. Rendic E., Diaz C., Fich F. Characterization of species of the gender Malassezia in patients with seborrheic dermatitis and subjects without skin lesions // Rev. Med. Chil. 2003. Vol. 131. Р. 1295–1300.
21. Gupta A.K., Kohli Y., Summerbell R.C., Faergemann J. Quantitative culture of Malassezia species from different body sites of individuals with or without dermatoses // Med. Mycol. 2001. Vol. 39. Р. 243–251.
22. Tajima M., Sugita T., Nishikawa A., Tsuboi R. Molecular analysis of Malassezia microflora in seborrheic dermatitis patients: comparison with other diseases and healthy subjects // J. Invest Dermatol. 2008. Vol. 128. Р. 345–351.
23. Bergbrant I.M. Seborrhoeic dermatitis and Pityrosporum ovale: cultural, immunological and clinical studies // Acta Derm Venereol Suppl (Stockh). 1991. Vol. 167. Р. 1–36.
24. Plotkin L.I., Squiquera L., Mathov I., Galimberti R., Leoni J. Characterization of the lipase activity of Malassezia furfur // J. Med. Vet. Mycol. 1996. Vol. 34. Р. 43–48.
25. DeAngelis Y.M., Saunders C.W., Johnstone K.R., Reeder N.L., Coleman C.G., Kaczvinsky J.R. Jr. et al. Isolation and expression of a Malassezia globosa lipase gene, LIP1 // J. Invest. Dermatol. 2007. Vol. 127. Р. 2138–2146.
26. Ro B.I., Dawson T.L. The role of sebaceous gland activity and scalp microfloral metabolism in the etiology of seborrheic dermatitis and dandruff // J. Investig. Dermatol. Symp. Proc. 2005. Vol. 10. Р. 194–197.
27. Dawson T.L.Jr. Malassezia globosa and restricta: breakthrough understanding of the etiology and treatment of dandruff and seborrheic dermatitis through whole-genome analysis // J. Investig. Dermatol. Symp. Proc. 2007. Vol. 12. Р. 15–19.
28. Borda L.J., Wikramanayake T.C. Seborrheic Dermatitis and Dandruff: A Comprehensive Review // J. Clin. Investigat. Dermatol. 2015. Vol. 3 (2). Р. 10.
29. Cowley N.C., Farr P.M., Shuster S. The permissive effect of sebum in seborrhoeic dermatitis: an explanation of the rash in neurological disorders // Br. J. Dermatol. 1990. Vol. 122. Р. 71–76.
30. Al-Dhalimi M.A. Neonatal and infantile erythroderma: a clinical and follow-up study of 42 cases // J. Dermatol. 2007. Vol. 34. Р. 302–307.
31. Berger R.S., Stoner M.F., Hobbs E.R., Hayes T.J., Boswell R.N. Cutaneous manifestations of early human immunodeficiency virus exposure // J. Am. Acad. Dermatol. 1988. Vol. 19. Р. 298–303.
32. Soeprono F.F., Schinella R.A., Cockerell C.J., Comite S.L. Seborrheic-like dermatitis of acquired immunodeficiency syndrome. A clinicopathologic study // J. Am. Acad. Dermatol. 1986. Vol. 14. Р. 242–248.
33. Blanes M.B.I., Merino E., Portilla J., Sánchez-Payá J., Betlloch I. Current prevalence and characteristics of dermatoses associated with human immunodeficiency virus infection // Actas Dermosifiliogr. 2010. Vol. 101. Р. 702–709.
34. Singh H., Singh P., Tiwari P., Dey V., Dulhani N., Singh A. Dermatological manifestations in HIV-infected patients at a tertiary carehospital in a tribal (Bastar) region of Chhattisgarh, India // Indian J. Dermatol. 2009. Vol. 54 (4). Р. 338–341.
35. Hakansson C., Faergemann J., Lowhagen G.B. Studies on the lipophilic yeast Pityrosporum ovale in HIV-seropositive and HIV-seronegative homosexual men // Acta Derm. Venereol. 1988. Vol. 68. Р. 422–426.
36. Rincón S., Celis A., Sopó L., Motta A., Cepero de García M.C. Malassezia yeast species isolated from patients with dermatologic lesions // Biomedica. 2005. Vol. 25. Р. 189–195.
37. Vidal C., Girard P.M., Dompmartin D., Bosson J.L., Mettra C., Groslambert P. et al. Seborrheic dermatitis and HIV infection. Qualitative analysis of skin surface lipids in men seropositive and seronegative for HIV // J. Am Acad Dermatol. 1990. Vol. 23. Р. 1106–1110.
38. Passi S., Picardo M., Morrone A., De Luca C., Ippolito F. Skin surface lipids in HIV sero-positive and HIV sero-negative patients affected with seborrheic dermatitis // J. Dermatol Sci. 1991. Vol. 2. Р. 84–91.
39. Nnoruka E.N., Chukwuka J.C., Anisuiba B. Correlation of mucocutaneous manifestations of HIV/AIDS infection with CD4 counts and disease progression // Int. J. Dermatol. 2007. Vol. 46, Suppl. 2. Р. 14–18.
40. Tschachler, MD, Professor of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, University of Vienna Medical School, Austria-HIV-related skin diseases // Journal of the Royal College of Physicians of London. 1997. Vol. 31 No. 4 July/August.
41. Dunic I., Vesic S., Jevtovic D.J. Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy // HIV Med. 2004. No. 5. Р. 50–54.
42. Hardcastle N.J., Tunbridge A.J., Shum K.W., Dockrell D.H., Green S.T. Alopecia in association with severe seborrhoeic dermatitis following combination antiretroviral therapy for acute retroviral syndrome // J. Eur. Acad. Dermatol. Venereol. 2005. Vol. 19. Р. 631–633.
43. Smith K., Kuhn L., Coovadia A., Meyers T., Hu C.C., Reitz C. et al. Immune reconstitution inflammatory syndrome among HIV-infected South African infants initiating antiretroviral therapy // AIDS. 2009. Vol. 23. Р. 1097–1107.
44. Schaub N.A., Drewe J., Sponagel L., Gilli L., Courvoisier S., Gyr N. et al. Is there a relation between risk groups or initial CD4 T cell counts and prevalence of seborrheic dermatitis in HIV-infected patients? // Dermatology. 1999. Vol. 198. Р. 126–129.
45. Schoefer H., Sachs D.L., Ochsendorf F. HIV-associated skin and mucocutaneous diseases // Hoffman C., Rockstroh J.K., Kamps B.S., eds. HIV medicine. 15 th ed. Paris, Cagliari, Wuppertal: Flying Publisher, 2007. 596 р.
46. Prose N.S. Cutaneous manifestations of HIV infection in children // Dermatol Clin. 1991. Vol. 9. Р. 543–550.
47. Dann F.J., Tabibian P. Cutaneous diseases in immunodeficiency vírus-infected patients referred to the UCLA Immunossupression skin Clinic: reasons for referral and management of select diseases // Cutis. 1995. Vol. 55. Р. 85–88.
48. Dunic I., Vesic S., Jevtovic D.J. Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy // HIV Med. 2004. Vol. 5. Р. 50–54.
49. Brännström J., Svedhem V., Marrone G., Andersson Ö., Azimi F., Blaxhult A., Sönnerborg A. Symptomatic Patients without Epidemiological Indicators of HIV Have a High Risk of Missed Diagnosis: A Multi-Centre Cross Sectional Study // PLOS ONE. doi: 10.1371/journal.pone.0162503 September 7, 2016
Review
For citations:
Khryanin A.A., Russkikh M.V., Bocharova V.K., Nadeev A.P. Seborrheic dermatitis associated with HIV infection: new concepts and hypotheses. HIV Infection and Immunosuppressive Disorders. 2020;12(4):98-107. (In Russ.) https://doi.org/10.22328/2077-9828-2020-12-4-98-107
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