DISORDERS OF BONE METABOLISMS IN HIV PAIENTS: CAUSES AND APPROACHES TO CORRECTION
https://doi.org/10.22328/2077-9828-2014-6-4-82-87
Abstract
HIV infection and HAART can reduce the minetal density of bones resulting in osteopenia and osteoporosis. We compared bone density in healthy people and HIV patients. In patients, bone ensity was reduced in all sites including forearm, femoraql neck, and lumbar spine. Osteoporosis and osteopenia was found more often in HIV patients than in healthy subjects.
About the Authors
V. V. Rassokhin
Saint-Petersburg Center for Control of AIDS and Infectious Diseases; Institute of Experimental Medicine of the Russian Academy
Russian Federation
Russian Federation
A. A. Sizov
Saint-Petersburg Center for Control of AIDS and Infectious Diseases
Russian Federation
Russian Federation
References
1. Остеопороз. Диагностика, профилактика и лечение / под ред. Л.И.Беневоленской, О.М.Лесняк.- М.: ГЭОТАР-Медиа, 2007.- 176 с.
2. Рассохин В.В. Органные поражения при ВИЧ-инфекции: в Кн. Вирус иммунодефицита человека - медицина / под ред. Н.А. Беляков, А.Г. Рахманова.- СПб.: Балтийский медицинский образовательный центр, 2011.- С. 153 - 156.
3. Рассохин В.В. Скрининговая оценка деминерализации костей у мужчин и женщин // ВИЧ-инфекция и иммуносупрессии. - 2012. - Т. 4, № 3.- С. 23-28.
4. Brown T.T., Qaqish R.B. Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review // AIDS.- 2006.- Vol. 20.- Р. 2165-2174.
5. Gibellini D., De Crignis E., Ponti C., Cimatti L., Borderi M., Tschon M., Giardino R., Re M.C. HIV-1 triggers apoptosis in primary osteoblasts and HOBIT cells through TNFα activation // J. Med. Virol.- 2008.- Vol. 80.- Р. 1507-1514.
6. Cotter E.J., Mallon P.W., Doran P.P. Is PPAR gamma a prospective player in HIV-1-associated bone disease? // PPAR Res.- 2009.- Vol. 2009.- Р 421376.
7. Fakruddin J.M., Laurence J. HIV envelope gp120-mediated regulation of osteoclastogenesis via receptor activator of nuclear factor kappa B ligand (RANKL) secretion and its modulation by certain HIV protease inhibitors through interferon-gamma / RANKL crosstalk // J.Biol. Chem.- 2003.- Vol. 278.- Р 48251-48258.
8. Wei S., Kitaura H., Zhou P., Ross F.P., Teitelbaum S.L. IL-1 mediates TNF-induced osteoclastogenesis // J.Clin. Invest.- 2005.- Vol. 115.- Р 282-290.
9. Hittinger G., Poggi C., Delbeke E., Profizi N., Lafeuillade A. Correlation between plasma levels of cytokines and HIV-1 RNA copy number in HIV-infected patients // Infection.- 1998.- Vol. 26.- Р 100-103.
10. McComsey G.A., Tebas P., Shane E., Yin M.T., Overton E.T., Huang J.S. Bone disease in HIV infection: a practical review and recommendations for HIV care providers // Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am.- 2010.- Vol. 51.- Р 937-946.
11. Lips P. Vitamin D physiology // Prog. Biophys. Mol. Biol.- 2006.- Vol. 92.- Р 4-8.
12. Kim J.H., Gandhi V., Psevdos Jr G., Espinoza F., Park J., Sharp V. Evaluation of vitamin D levels among HIV-infected patients in New York City // AIDS Res Hum Retrovir.- 2012.- Vol. 28.- Р 235-241.
13. Gregg E.W., Cauley J.A., Seeley D.G., Ensrud K.E., Bauer D.C. Physical activity and osteoporotic fracture risk in older women. Study of osteoporotic fractures research group // Ann. Intern. Med.- 1998.- 129.- Р 81-88.
14. Mora S., Zamproni I., Zuccotti G., Vigano A. Pediatric HIV infection and bone health: an emerging challenge // Front. Biosci.- 2010.- Vol. 2.- Р 1265-1274.
Review
For citations:
Rassokhin V.V., Sizov A.A. DISORDERS OF BONE METABOLISMS IN HIV PAIENTS: CAUSES AND APPROACHES TO CORRECTION. HIV Infection and Immunosuppressive Disorders. 2014;6(4):82-87. (In Russ.) https://doi.org/10.22328/2077-9828-2014-6-4-82-87
Views:
1872
.png)
Email this article 