Incidence of community-acquired pneumonia in HIV-infected people, depending on the level of immunodeficiency and viral load
https://doi.org/10.22328/2077-9828-2021-13-2-62-65
Abstract
The aim of the study was to study the timing and frequency of community — acquired pneumonia in HIV-infected people, depending on the level of immunodeficiency and viral load.
Materials and methods. Based on the materials of the Perm regional center for the fight and prevention of AIDS and infectious diseases, medical documentation was studied for 396 patients with HIV-associated pneumonia who died in 2014–2018 the frequency of community-acquired pneumonia (EAP) was estimated depending on the level of immunodeficiency and viral load.
Results and discussion. It turned out that in most cases, EAP in relation to HIV infection is a secondary disease. The average duration of EAP after HIV infection was 4,6±3,7 years. With increasing immunodeficiency and viral load, the incidence of VP increases. Most often, VP is registered with CD4+ lymphocytes less than 200 cells/μl and viral load of 10 000–100 000 copies/ml.
About the Authors
V. I. Sergevnin
Perm State Medical University named after Academician E. A. Wagner
Russian Federation
Russian Federation
Perm
K. V. Ovchinnikov
Perm Regional Center for Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Russian Federation
Perm
E. V. Sarmometov
Perm Regional Center for Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Russian Federation
Perm
A. A. Kirshina
Perm State Medical University named after Academician E. A. Wagner
Russian Federation
Russian Federation
Perm
References
1. Rubaihayo J., Tumwesigye N.M., Konde-Lule J. Trends in prevalence of diarrhoea, Kaposi’s sarcoma, bacterial pneumonia, malaria and geohelminths among HIV positive individuals in Uganda // AIDS Research and Therapy. 2015. No. 12. Р. 20–24. doi: 10.1186/s12981-015-0060-0.
2. Hirschtick R.E., Glassroth J., Jordan M.C. Bacterial pneumonia in persons infected with the human immunodeficiency virus. Pulmonary Complications of HIV Infection Study Group // N. Engl. J. Med. 1995. Vol. 333, No. 13. Р. 845–851.
3. Chou S.H., Prabhu S.J., Crothers K. Thoracic Diseases Associated with HIV Infection in the Era of Antiretroviral Therapy: Clinical and Imaging Findings // Radiographics. 2014. Vol. 34, No. 4. P. 895–911. doi: 10.1148/rg.344130115.
4. Puzyreva L.V., Nazarova O.I., Dovgopolyuk et al. Respiratory diseases in the structure of deaths in HIV-infected patients in the Omsk region. Immunopathology, Allergology, Infectology, 2018, No. 3, рр. 19–26 (In Russ.).
5. Viktorova E.A., Azovceva O.V. Тhe рathomorphological changes at the AIDS-associated diseases with the defeat of breathing organs. International magazine of medicine and psychology, 2019, Vol. 2, No. 3, рр. 74–80 (In Russ.).
6. Lamas C.C., Coelho L.E., Grinsztejn Beatriz J. et al. Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study // Infection. 2017. Vol. 45, No. 6. P. 801–809. doi: 10.1007/s15010-017-1041-0.
7. Theodoratou E., McAllister А., Reed C. et al. Global, regional, and national estimates of pneumonia burden in HIV-infected children in 2010: a meta-analysis and modelling study // Lancet Infect Dis. 2014. Vol. 14, No. 12. Р. 1250–1258. doi: 10.1016/S1473-3099(14)70990-9.
8. Albrich W. C., Madhi S.A., Adrian P.V. et al. Pneumococcal colonisation density: a new marker for disease severity in HIV-infected adults with pneumonia // BMJ Open. 2014. Vol. 4, No. 8. doi: 10.1136/bmjopen-2014-005953.
9. Lawani M.B., Morris A. The respiratory microbiome of HIV-infected individuals // Expert. Rev. Anti Infect. Ther. 2016. Vol. 14, No 8. P. 719–729. doi: 10.1080/14787210.2016.1206469.
10. Feldman C., Anderson R. HIV-associated bacterial pneumonia // Clin. Chest. Med. 2013. Vol. 34, No. 2. Р. 205–216. doi: 10.1016/j.ccm.2013.01.006.
11. Steenhoff A.P., Josephs J.S., Rutstein R.M. et al. Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000–2005 // AIDS. 2011. Vol. 25, No. 5. Р. 717–720.
12. Zimina V.N., Astaf’ev A.V. Community-acquired pneumonia in adult patients with HIV infection: features of the course and treatment, prevention. Pulmonology, 2016, Vol. 26, No. 4, рр. 488–497 (In Russ.).
Review
For citations:
Sergevnin V.I., Ovchinnikov K.V., Sarmometov E.V., Kirshina A.A. Incidence of community-acquired pneumonia in HIV-infected people, depending on the level of immunodeficiency and viral load. HIV Infection and Immunosuppressive Disorders. 2021;13(2):62-65. (In Russ.) https://doi.org/10.22328/2077-9828-2021-13-2-62-65
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