STUDY OF PROPERTIES OF SERUM NEUTRALIZING HIV-INFECTED PATIENTS WITH NON-PROGRESSORS DISEASES OF HIV ISOLATES OF DIFFERENT GENETIC VARIANTS
https://doi.org/10.22328/2077-9828-2015-7-1-45-51
Abstract
In connection with the existing problems in developing a vaccine, which causes time between antibodies against various strains of HIV-1, there is need to develop methods to assess virus neutralization, as well as search for broadly neutralizing antibodies capable of blocking various HIV-1 strains. We investigated the serum of HIV-infected people with non-progressive form of the disease. In our work we used serum subtype A and CRF63_02A1, and the panel of infectious HIV-1 isolates isolated from recently infected patients different genetic and biological characteristics. Reactions were carried out neutralization between homo- and heterologous pairs serum HIV-1 isolate. Analysis showed weaker suppression isolates CRF63_02A1 recombinant form of HIV-1, while sera from individuals infected CRF63_02A1, the vast majority of the studied isolates us, including the homologous HIV-1 isolates.
About the Authors
N. A. Blednyh
State Research Center of Virology and Biotechnology «Vector»
Russian Federation
Russian Federation
N. V. Unagaeva
State Research Center of Virology and Biotechnology «Vector»
Russian Federation
Russian Federation
Y. V. Nikonorova
State Research Center of Virology and Biotechnology «Vector»
Russian Federation
Russian Federation
F. O. Mirdzhamalova
Center for Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Russian Federation
N. Y. Chernousova
Center for Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Russian Federation
S. R. Sauhat
Federal State Institution of Science Rostov Research Institute of Microbiology and Parasitology of Rospotrebnadzor
Russian Federation
Russian Federation
N. M. Gashnikova
State Research Center of Virology and Biotechnology «Vector»
Russian Federation
Russian Federation
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Review
For citations:
Blednyh N.A., Unagaeva N.V., Nikonorova Y.V., Mirdzhamalova F.O., Chernousova N.Y., Sauhat S.R., Gashnikova N.M. STUDY OF PROPERTIES OF SERUM NEUTRALIZING HIV-INFECTED PATIENTS WITH NON-PROGRESSORS DISEASES OF HIV ISOLATES OF DIFFERENT GENETIC VARIANTS. HIV Infection and Immunosuppressive Disorders. 2015;7(1):45-51. (In Russ.) https://doi.org/10.22328/2077-9828-2015-7-1-45-51
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