Analysis of HIV prevalence, tuberculosis and their combinations in the territory of Chechen Republic

Objective. Analyse the prevalence of combined HIV/TB infections in the territory of Chechen Republic for 2013–2020.
Materials and methods. The research was held by «the Republican Centre for AIDS Prevention and Control», Grozny and «The Republican Centre of Phthisiopulmonology», Grozny. It analysed the data of outpatient and inpatient charts of 148 HIVinfected with tuberculosis, identified in the period from 2013 to 2020 and being under dispensary observation in the Republican Centre of AIDS Prevention and Control, Chechen Republic.
Results and discussion. The study reports that HIV prevalence in absolute terms and figures per 100.000 people decreased from 223 (16,8) in 2013 to 117 (7,9) in 2020. It should be noted that with the growth in number of checked people, tuberculosis prevalence as well as in the case of HIV infection decreased in absolute terms and figures per 100.000 of the population in the sampling period. If in 2013 it amounted 466 (35,1), in 2020 it was already 299 (20,2). Among HIV-infected citizens of Chechen Republic 167 people with tuberculosis were also detected in the sampling period. From among the combined HIV- and tuberculosis infected, 148 people subjected to regular medical check-up. The prevalence of combined HIV/TB infections per 100.000 people tended to decrease from 2013 to 2020 as well as the overall HIV prevalence without tuberculosis and tuberculosis without HIV. These changes are quite significant from 1,6 to 0,06.
Conclusion. The issues of HIV infection combined with tuberculosis remains actual for all constituent entities of the Russian Federation, including Chechen Republic, based on socio-economic, demographic, epidemiological and clinical reasons. The decline in incidence and prevalence of HIV, tuberculosis and combined HIV/TB infections in the territory of Chechen Republic in 2013–2020 may have occurred due to increase in the level of economic development, favourable social programs and stabilization of demographic situation, демографической ситуации, overall reduction of substance abuse, including parenterally injectable. There is also improvement of material and technical equipment, staffing of infectious and anti-tuberculosis service. It is required to have further study of the epidemic process specificities of socially significant infections (HIV, TB, viral hepatitis) that acquire new features and characteristics during the pandemic of the new coronaviral infection.

1. Покровский В.В., Ладная Н.Н., Соколова Е.В. ВИЧ-инфекция. Информационный бюллетень № 46. Москва, 2021. 83 с., ил. [Pokrovsky V.V., Ladnaya N.N., Sokolova E.V. HIV infection. Newsletter No. 46. Moscow, 2021. 83 p., ill. (In Russ.)].

2. ВИЧ-инфекция и коморбидные состояния в Северо-Западном федеральном округе Российской Федерации в 2020 году: аналитический обзор / под ред. Н. А. Белякова. СПб.: ФБУН НИИЭМ имени Пастера, 2021. 60 с. [HIV infection and comorbid conditions in the Northwestern Federal District of the Russian Federation in 2020: an analytical review / ed. N. А. Belyakov. St. Petersburg: FBUN NIIEM named after Pasteur, 2021. 60 p. (In Russ.)].

3. Lawn S.D., Zumla A.I. Tuberculosis // Lancet. 2011. Vol. 378. P. 57–72. doi: 10.1016/s0140-6736(10)62173-3.

4. Пантелеев А.М. Туберкулез органов дыхания у больных с ВИЧ-инфекцией // ВИЧ-инфекция и иммуносупрессии. 2010. Т. 2, № 1. С. 16– 22. [Panteleev A.M. Respiratory tuberculosis in patients with HIV infection. HIV Infection and Immunosuppressive Disorders, 2010, Vol. 2, No. 1, рр. 16–22 (In Russ.)].

5. Беляков Н.А., Рассохин В.В., Трофимова Т.Н., Степанова Е.В., Пантелеев А.М., Леонова О.Н., Бузунова С.А., Коновалова Н.В., Миличкина А.М., Тотолян А.А. Коморбидные и тяжелые формы ВИЧ-инфекции в России // ВИЧ-инфекция и иммуносупрессии. 2016. Т. 8, № 3. С. 9–25. [Belyakov N.A., Rassokhin V.V., Trofimova T.N., Stepanova E.V., Panteleev A.M., Leonova O.N., Buzunova S.A., Konovalova N.V., Milichkina A.M., Totolyan A.A. Comorbid and severe forms of HIV infection in Russia. HIV Infection and Immunosuppressive Disorders, 2016, Vol. 8, No. 3, рр. 9–25 (In Russ.)].

6. Старшинова А.А., Пантелеев А.М., Манина В.В., Истомина Е.В., Афонин Д.Н., Журавлев В.Ю. Возможности различных иммунологических тестов в диагностике туберкулеза у пациентов с ВИЧ-инфекцией // Туберкулез и болезни легких. 2016. Т. 94, № 8. С. 14–22. [Starshinova A.A., Panteleev A.M., Manina V.V., Istomina E.V., Afonin D.N., Zhuravlev V.Yu. Possibilities of various immunological tests in the diagnosis of tuberculosis in patients with HIV infection. Tuberculosis and Lung Diseases, 2016, Vol. 94, No. 8, рр. 14–22 (In Russ.)].

7. Suthar A.B., Lawn S.D., del Amo J., Getahun H., Dye C., Sculier D., Sterling T.R., Chaisson R.E., Williams B.G., Harries A.D., Granich R.M. Antiretroviral therapy for prevention of tuberculosis in adults with HIV: a systematic review and meta-analysis. 2012 // PLoS Med. 2012. Vol. 9 (7). P. e1001270 [Electronic resource]. doi: 10.1371/journal.pmed.1001270.

8. Михайлова Н.Р., Логинов А.В., Соколова О.А. Клинические проявления туберкулеза у больных на поздних стадиях ВИЧ-инфекции // Международная научно-практическая конференция «Актуальные вопросы ВИЧ-инфекции». 2016. С. 106–108 [Mihajlova N.R., Loginov A.V., Sokolova O.A. Clinical manifestations of tuberculosis in patients with late stages of HIV infection. International scientific and practical conference «Actual issues of HIV infection», 2016, рp. 106–108 (In Russ.)].

9. Карасева Т.В., Козлова А.В., Лешок С.Н., Белобородова Н.Г., Леванова Е.Е., Решетникова С.В., Куминов А.А., Козлова О.Ф. Генерализованный туберкулез — маркер ВИЧ-инфекции // Университетская медицина Урала. 2016. №. 2. С. 24–26 [Karaseva T.V., Kozlova A.V., Leshok S.N., Beloborodova N.G., Levanova E.E., Reshetnikova S.V., Kuminov A.A., Kozlova O.F. Generalized tuberculosis is a marker of HIV infection. University medicine of the Urals, 2016, No. 2, рp. 24–26 (In Russ.)].

10. Беляков Н.А., Рассохин В.В. ВИЧ-инфекция и коморбидные состояния. СПб.: Балтийский медицинский образовательный центр, 2020. 680 с., илл. [Belyakov N.A., Rassokhin V.V. HIV infection and comorbid conditions. St. Petersburg: Publishing house Baltic Medical Education Center, 2020. 680 p., ill. (In Russ.)].

11. Беляков Н.А., Рассохин В.В., Трофимова Т.Н., Колбин А.С. и др. Персонализированная ВИЧ-медицина / под ред. Н. А. Белякова. СПб.: Балтийский медицинский образовательный центр, 2020. 326 с., илл. [Belyakov N.A., Rassokhin V.V., Trofimova T.N., Kolbin A.S. et al. Personalized HIV Medicine / ed. N. А. Belyakov. St. Petersburg: Publishing house Baltic Medical Education Center, 2020. 326 p., ill. (In Russ.)].

12. Ашенова Г.Ж., Галкин В.Б., Загдын З.М. и др. ТБ/ВИЧ в Российской Федерации. Эпидемиология, особенности клинических проявлений и результаты лечения: монография / под ред. С. А. Стерликова. М.: РИО ЦНИИОИЗ, 2018. 67 с. [Ashenova G.Zh., Galkin V.B., Zagdyn Z.M. et al. TB/HIV in the Russian Federation. Epidemiology, features of clinical manifestations and results of treatment: monograph / ed. S. A. Sterlikov. Moscow: Publishing house RIO TsNIIOIZ, 2018. 67 p. (In Russ)].

13. Юнкеров В.И., Григорьев С.Г., Резванцев М.В. Математико-статистическая обработка данных медицинских исследований. СПб.: ВМА, 2011. 318 с. [Yunkerov V.I., Grigoryev S.G., Rezvantsev M.V. Mathematical and statistical processing of medical research data. St. Petersburg: Рublishing house VMA, 2011. 318 р. (In Russ.)].

14. Беляков Н.А., Боева Е.В., Симакина О.Е., Светличная Ю.С., Огурцова С.В., Серебрякова С.Л., Эсауленко Е.В., Загдын З.М., Язенок А.В., Лиознов Д.А., Стома И.О. Пандемия COVID-19 и ее влияние на течение других инфекций на Северо-Западе России // ВИЧ-инфекция и иммуносупрессии. 2022. Т. 14, № 1. С. 7–24. [Belyakov N.A., Boeva E.V., Simakina O.E., Svetlichnaya Yu.S., Ogurtsova S.V., Serebryakova S.L., Esaulenko E.V., Zagdyn Z.M., Yazenok A.V., Lioznov D.A., Stoma I.O. COVID-19 pandemic and its impacton other infections in Northwest Russia. HIV-Infection and Immunosuppressive Disorders, 2022, Vol. 14, No. 1, рр. 7–24 (In Russ)]. doi: 10.22328/2077-9828-2022-14-1-7-24.