The causes of TB development in a child with HIV infection
https://doi.org/10.22328/2077-9828-2023-15-4-98-104
Abstract
The article represents a clinical observation of the development of disseminated TB in a 12-year-old child with HIV infection, a high CD4 lymphocyte count (1315 cells/μl), and undetectable viral load (<20 copies per ml of blood). Perinatal transmission occurred, HIV infection was diagnosed immediately after birth, ART was administered from the first days of life. The girl has lived in a foster family since the age of 12 months. Poor adherence to treatment resulted in raised viral load. At the same time, the girl got ill with severe measles. ART was corrected with a rapid positive immunological and virological effect. One year later, TB manifested under the guise of acute bronchopulmonary disease. The examination revealed traces of infancy intrathoracic lymph node TB in the form of small calcinates. The patient had not been previously examined for TB infection and never received preventive TB treatment. The development of acute progressive TB in the child with HIV infection and satisfactory immunological and virological indicators was caused by: lack of due interdisciplinary (pediatricians, infectiologists, phthisiologists) and interdepartmental (medical services, children’s services) interactions; poor adherence to treatment; past measles.
About the Authors
M. F. Gubkina
Central TB Research Institute;
N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
Yu. Yu. Khokhlova
Central TB Research Institute
Russian Federation
Russian Federation
Moscow
N. V. Yukhimenko
Central TB Research Institute
Russian Federation
Russian Federation
Moscow
I. Yu. Petrakova
Central TB Research Institute
Russian Federation
Russian Federation
Moscow
S. S. Sterlikova
Central TB Research Institute
Russian Federation
Russian Federation
Moscow
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For citations:
Gubkina M.F., Khokhlova Yu.Yu., Yukhimenko N.V., Petrakova I.Yu., Sterlikova S.S. The causes of TB development in a child with HIV infection. HIV Infection and Immunosuppressive Disorders. 2023;15(4):98-104. (In Russ.) https://doi.org/10.22328/2077-9828-2023-15-4-98-104
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