The case of coinfection with human immunodeficiency and hepatitis С viruses during hemotransfusion: clinical and socio-legal consequences

In Russia, cases of HIV transmission related to medical care are registered annually, including cases related to hemotransfusion. A clinical case of an artificial coinfection with human immunodeficiency and hepatitis C viruses in the course of medical care, as well as its clinical, social, legal and economic consequences, is presented. This clinical case is noteworthy for its relevance from both the perspective of examining the clinical course and treatment of illnesses, as well as analyzing the medical and legal implications of a iatrogenically acquired infection. The recurrence of such incidents of infection with significant social diseases in the 1990s and 2000s necessitated a serious reorganization of the national blood transfusion system and blood components. At present, with strict adherence to legal requirements in place, the risk of infection has been minimized.

1. Ladnaya N.N., Sokolova E.V., Pokrovsky V.V. Transmission of HIV infection associated with the provision of medical care in the Russian Federation. Control and prevention of infections associated with the provision of medical care (HAI-2023): collection of abstracts of the XI Congress with international participation. Moscow: Central Research Institute of Epidemiology of Rospotrebnadzor, 2023, рp. 53–54 (In Russ.).

2. Ladnaya N.N., Chekryzhova D.G., Sokolova E.V., Pokrovsky V.V. Transmission of HIV infection through transfusion of blood components in the Russian Federation. Control and prevention of infections associated with the provision of medical care (HAI-2022): collection of abstracts of the X Congress with international participation. Moscow: Central Research Institute of Epidemiology of Rospotrebnadzor, 2022, рp. 62–63 (In Russ.).

3. Sokolova E.V., Ladnaya N.N., Pokrovsky V.V. HIV infection in donors in the Russian Federation. Infectious diseases in the modern world: evolution, current and future threats: collection of proceedings of the XV Annual All-Russian Congress on Infectious Diseases named after Academician V. I. Pokrovsky. Moscow: Limited Liability Company «Medical Marketing Agency», 2023, р. 206 (In Russ.).

4. Rudakova A.V. Cost analysis of the first line antiretroviral therapy in Russian Federation. Journal Infectology, 2014, Vol. 6. No. 1, pp. 72–77 (In Russ.). doi: 10.22625/2072-6732-2014-6-1-72-77.

5. Tarasenko A.O., Shubina Yu.F. Rational laboratory diagnosis of viral hepatitis C in the blood service. The Scientific Notes of the Pavlov University, 2009, Vol. 16, No. 3, pp. 113–116 (In Russ.).

6. Ulyukin I.M., Orlova E.S., Bulankov Yu.I. Occult hepatitis B in the light of ensuring infectious safety of blood transfusions and control of antiviral therapy for the disease. Bulletin of St. Petersburg University, 2015, Iss. 4, pp. 156–164 (In Russ.).

7. Golubeva I.F., Shalnova E.E., Bochkova G.B. Infectious risks and ensuring the safety of donor blood and its components. Laboratory diagnosis of infectious diseases, 2019, No. 1 (19), pp. 6–22 (In Russ.).

8. Vysotskaya A.V., Shalnova E.E., Fisenko N.S. International and national requirements for viral safety of donated blood. Laboratory diagnosis of infectious diseases, 2019, No. 1 (19), pp. 36–52 (In Russ.).

9. Belyakova V.V., Gukasyan I.A., Donskaya O.V., Mayorova O.A., Dashkova N.G., Ragimov A.A. Residual risks of transfusion-transmission of HIV infection and viral hepatitis C in the Moscow region during laboratory screening of donor blood using NAT technologies. Hematology and Transfusiology, 2014, Vol. 59, No. 1, pp. 15–18 (In Russ.).

10. Gubanova M.N., Chemodanov I.G., Gaivoronskaya V.V., Ayupova R.F., Kozhemyako O.V., Averyanov E.G., Madzaev S.R., Zhiburt E.B. Inactivation pathogens in cellular components of blood. Transfusiology, 2017, Vol. 18, No. 3, pp. 15–36 (In Russ.).

11. Zhdanov K.V., Ivanov A.M., Bolekhan V.N., Bulankov Yu.I., Aminev R.M., Voronin S.V., Gorichny V.A., Zakharenko S.M., Orlova E.S., Butakov S.S., Bulygin M.A., Murachev A.A. HIV infection: diagnosis, treatment and prevention in the Armed Forces of the Russian Federation (guidelines). Moscow: Main military medical department of the Russian Federation Ministry of Defense, 2019. 98 p. (In Russ.).

12. Bulankov Yu.I., Bulygin M.A., Zhdanov K.V., Murachev A.A., Bulygina D.S., Orlova E.S. Сlinical and epidemiological characteristics of HIV-positive servicemen in Russian Ministry of Defence as justification for directions of optimizing the medical care to servicemen. HIV Infection and Immunosuppressive Disorders, 2020, Vol. 12, No. 4, pp. 32–42 (In Russ.). doi: 10.22328/2077-9828-2020-12-4-32-42.

13. Bulankov Yu.I., Bulygin M.A., Zhdanov K.V., Kozlov K.V., Lyashenko Yu.I., Ivanov K.S., Orlova E.S. History of the formation and problems of the system for countering infection caused by the human immunodeficiency virus in the Armed Forces of the Russian Federation. Bulletin of the Russian Military Medical Academy, 2018, Vol. 20, No 4, pp. 199–207 (In Russ.). doi: 10.17816/brmma12362.

14. Kireev D.E., Shipulin G.A., Semenov A.V., Tivanova E.V., Chulanov V.P., Kolyasnikova N.M., Zueva E.B., Galli C., Pokrovsky V.V. Comparative evaluation of the 4th generation ELISA/CLIA assays used for the diagnosis of HIV infection in the Russian Federation. HIV Infection and Immunosuppressive Disorders, 2019, Vol. 11, No. 2, pp. 103– 113 (In Russ.). doi: 10.22328/2077-9828-2019-11-2-103

15. Samarina A.V., Yastrebova Ye.B., Lisitsyna Z.N., Dement’Yeva N.Ye., Voropayeva Ye.N., Sizova N.V., Rassokhin V.V., Panteleyeva O.V., Koltsova O.V., Abramova I.A., Dmitriyev A.V., Belyakov N.A. Case report about successful HIV prevention after transfusion of HIV-infected erythrocyte suspension. HIV Infection and Immunosuppressive Disorders, 2015, Vol. 7, No. 3, pp. 87–96 (In Russ.). doi: 10.22328/2077-9828-2015-7-3-87-96