A case of nephronephrosis development in a patient with AA-amyloidosis of the kidneys and HIV-infection
https://doi.org/10.22328/2077-9828-2025-17-4-110-114
Abstract
The relevance of HIV infection is clear due to the steady increase in the number of people living with HIV (PLHIV). The aim: To present a clinical case of nephronephrosis in a patient with renal AA amyloidosis and HIV infection following COVID-19.
Materials and methods. In this clinical case, a patient with HIV infection (CD4 lymphocyte count of 420 cells/mL) developed bilateral nephronephrosis with acute renal failure. Signs of acute kidney injury were observed: proximal and distal tubular epithelium with karyolysis, and the cytoplasm of some cells was coagulated.
Results and discussion. A possible cause of acute kidney injury could be a previous COVID-19 infection one month prior to hospitalization. Although the patient had no previous complaints, traces of protein were present in a urinalysis. COVID-19 patients experience a cytokine storm, disrupting the function of all organs, including the kidneys. These disruptions often persist even after the symptoms of coronavirus infection resolve.
Conclusion: COVID-19 infection should likely be considered an additional risk factor for kidney damage in HIV-infected patients.
About the Authors
O. V. Alpidovskaya
Chuvash State University named after I. N. Ulyanov
Russian Federation
Russian Federation
Alpidovskaya Olga Vasilievna
Cheboksary
L. P. Romanova
Chuvash State University named after I. N. Ulyanov
Russian Federation
Russian Federation
Cheboksary
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Review
For citations:
Alpidovskaya O.V., Romanova L.P. A case of nephronephrosis development in a patient with AA-amyloidosis of the kidneys and HIV-infection. HIV Infection and Immunosuppressive Disorders. 2025;17(4):110-114. (In Russ.) https://doi.org/10.22328/2077-9828-2025-17-4-110-114
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