A case of meningoencephalitis in a patient with HIV infection in the Zaporizhia region
https://doi.org/10.22328/2077-9828-2025-17-4-115-124
Abstract
Aim: to conduct a prospective analysis of the medical history and management tactics of a patient with meningoencephalitis on the background of HIV infection.
Materials and methods. A patient with HIV infection who was hospitalized in the infectious diseases department of the Melitopol Regional Hospital was under dynamic supervision. The patient was managed in accordance with clinical symptoms (treatment of meningoencephalitis) and national clinical guidelines (treatment of patients with HIV infection). The results of the survey were discussed with the participation of related specialists.
Result and its discussion. HIV infection in a patient who does not receive ART can occur with numerous complications. Despite the search for an infectious agent, a comprehensive examination of the patient failed to identify the causative agent of meningoencephalitis. The patient’s neurological symptoms could not be eliminated, but his general condition improved during treatment.
Conclusion. Increasing adherence to ART therapy is a key task in the prevention of secondary complications in patients with HIV infection. It is necessary to expand the range of laboratory techniques that make it possible to identify the maximum possible number of potential pathogens of purulent-septic brain infections in daily clinical practice.
About the Authors
E. E. KruglovRussian Federation
Kruglov Egor Evgenievich
Samara
St. Petersburg
D. D. Kruglova
Russian Federation
Melitopol
A. V. Zhestkov
Russian Federation
Samara
References
1. Shevchenko N.V., Kuznetsov S.M., Darmaev A.D., Ochirov B.V., Shchelkova I.A., Zyryanov A.A., Pyrenkov D.A., Mitskevich A.S., Vashchenko P.P., Shinkorenko V.S., Makarova N.A., Targashina T.B., Sidelnikov A.P., Onishchuk Yu.V. Complex a diagnostic case of meningoencephalitis in a patient with HIV infection. Bulletin of the BSU. Medicine and pharmacy, 2020, No. 1, pp. 21–33 (In Russ.).
2. Nagibina M.V., Bessarab T.R., Vengerov Yu.Ya., Mazus A.I., Tishkevich O.A., Smirnova T.Yu., Svistunova T.S., Tuglanova B.M. Listeriosis meningoencephalitis as an opportunistic disease in HIV infection. Journal Infectology, 2023, Vol. 15, No. 1, pp. 68–77 (In Russ.). doi: 10.22625/2072-6732-2023-15-1-68-77.
3. Katchanov J., Branding G., Stocker H. Central pontine myelinolysis in advanced HIV infection with tuberculosis and multicentric Castleman’s disease // International journal of STD & AIDS. 2013. Vol. 24, No. 7. P. 583–587. doi: 10.1177/0956462413477557.
4. Kaplitsky A., Antipenko E., Sidorenkova E., Shilov D., Gustov A. HIV-associated tuberculous meningoencephalitis: rarity or regularity?. Vrach, 2019, Vol. 30, No. 7, pp. 42–46 (In Russ.). doi: 10.29296/25877305-2019-07-08.
5. Zhao M., Zhuo C., Li Q., Liu L. Cytomegalovirus (CMV) infection in HIV/AIDS patients and diagnostic values of CMV-DNA detection across different sample types // Ann. Palliative Med. 2020. Vol. 9, No. 6. P. 2710–2715. doi: 10.21037/apm-20-1352.
6. Shakhgildyan V.I., Tsvetkova O.O., Ermak T.N., Gruzdev B.M., Yuditsky M.V., Tishkevich O.A., Shipulina O.Yu., Alvarez Figueroa M.V., Safonova A.P., Dolgova E.A., Goncharov D.B. The structure of damage to the central nervous system in patients with HIV infection in specialized departments of the Infectious diseases hospital. Therapeutic Archive, 2010, Vol. 82, No. 11, pp. 22–27 (In Russ.).
7. Kapustin D.V., Krasnova E.I., Khokhlova N.I., Shishkova O.M., Pozdnyakova L.L. Modern aspects of central nervous system damage in patients with HIV infection (literature review). Journal of Infectology, 2023, Vol. 15, No. 3, pp. 15–28 (In Russ.). doi: 10.22625/2072-6732-2023-15-3-15-28.
8. Voznesenskiy S.L., Sakhgildyan V.I., Petrova E.V., Kozhevnikova G.M., Ermak T.N., Tishkevich O.A., Samotolkina E.S., Soboleva Z.A., Emerole K.C. Unspecified encephalitis in HIV-infected patients: clinical and postmortem evaluation. Therapeutic archive, 2021, Vol. 93, No. 11, pp. 1278–1282 (In Russ.). doi: 10.26442/00403660.2021.11.201197.
9. Trofimova T., Rassokhin V.V., Leonova O.N., Shelomov A.S., Yakovlev A.A., Azovtseva O.V., Bakulina E.G., Belyakov N.A. Lesions of brain structures in HIV infection. Medical academic journal, 2019, Vol. 19, No. 3, pp. 83–95 (In Russ.). doi: 10.17816/MAJ19383-95.
10. Abbuehl L.S., Branca M., Ungureanu A., Federspiel A., Leib S.L., Bassetti C.L. A., Hakim A., Dietmann A. Magnetic resonance imaging in acute meningoencephalitis of viral and unknown origin: frequent findings and prognostic potential // Frontiers in neurology. 2024. Vol. 15. P. 1359437. doi: 10.3389/fneur.2024.1359437.
11. Li J., Xiong G., Huang Z., Li G., Xiao B., Zhu D., Tan X., Liu Y. Parkinsonism with long term use of Lamivudine // Neurology Asia. 2007. No. 12. P. 111–113.
12. Xu H., Wang Z., Zheng L., Zhang W., Lv H., Jin S., Yuan Y. Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion // Journal of clinical pathology. 2014. Vol. 67, No. 11. P. 999–1005. doi: 10.1136/jclinpath-2013-202069.
13. Gräfe M., Schäfer M.S., Leithner C., Allers K., Schneider T., Algharably E.E.A., Kreutz R., Riemer T.G. Neuropsychiatric adverse events in tenofovir disoproxil fumarate- and tenofovir alafenamide–based HIV therapy and prophylaxis: a systematic review and meta-analysis // Pol. Arch. Intern. Med. 2024. Vol. 134, No. 11. P. 16861. doi: 10.20452/pamw.16861.
14. Variava E., Sigauke F.R., Norman J., Rakgokong M., Muchichwa P., Mochan A., Maartens G., Martinson N.A. Brief Report: Late Efavirenz-Induced Ataxia and Encephalopathy: A Case Series // Journal of acquired immune deficiency syndromes. 2017. Vol. 75, No. 5. P. 577–579. doi: 10.1097/QAI.0000000000001451.
15. Arnab P., Croxford R., Scott J., Perumal S., Mohammed Z., Wiesner L., Cohen K., Wasserman S. Severe efavirenz associated neurotoxicity: A retrospective cohort study // Southern African journal of infectious diseases. 2023. Vol. 38, No. 1. P. a522. doi: 10.4102/sajid.v38i1.522.
Review
For citations:
Kruglov E.E., Kruglova D.D., Zhestkov A.V. A case of meningoencephalitis in a patient with HIV infection in the Zaporizhia region. HIV Infection and Immunosuppressive Disorders. 2025;17(4):115-124. (In Russ.) https://doi.org/10.22328/2077-9828-2025-17-4-115-124
JATS XML

.png)





























