Preview

HIV Infection and Immunosuppressive Disorders

Advanced search

Сlinical and epidemiological characteristics, adverse consequences of West Nile fever

https://doi.org/10.22328/2077-9828-2026-18-2-7-20

Abstract

This article will review the main characteristics of West Nile fever virus (WNV), including its spread, pathogenesis, clinical manifestations, and long-term effects on human health. The main focus will be on analyzing the interaction of the virus with various body systems, the mechanisms of its penetration into tissues, and the characteristics of the immune response to infection. The study covers the molecular aspects of pathogenesis, the genetic structure of the virus, the dynamics of its spread, as well as diagnostic, preventive and treatment methods. Particular importance is attached to the analysis of the characteristics of various virus strains, their evolution and geographical distribution. This will allow us to identify trends in the development of infection and develop strategic approaches to its prevention. The study of the mechanisms of the virus’s effects on the nervous, visual and cardiovascular systems, as well as the identification of factors influencing the development of complications, are key aspects of this work. The article is intended for specialists in the field of medicine, including students, residents, postgraduates of medical schools and doctors of various medical specialties.

About the Authors

O. N. Krasnorutskaya
Voronezh State Medical University named after N. N. Burdenko
Russian Federation

Krasnorutskaya Olga Nikolaevna - Dr. of Sci. (Med.)

Voronezh



V. V. Rassokhin
The first St. Petersburg State Medical University named after Academician I. P. Pavlov; St. Petersburg Pasteur Research Institute of Epidemiology and Microbiology
Russian Federation

Rassokhin Vadim Vladimirovich - Dr. of Sci. (Med.), Professor

St. Petersburg



V. I. Shevtsova
Voronezh State Medical University named after N. N. Burdenko
Russian Federation

Shevtsova Veronika Ivanovna — Dr. of Sci. (Med.)

Voronezh



A. A. Istin
Voronezh State Medical University named after N. N. Burdenko
Russian Federation

Istin Alexander Alexandrovich

Voronezh



N. A. Nasonova
Voronezh State Medical University named after N. N. Burdenko
Russian Federation

Natalia Alexandrovna Nasonova — Cand. of Sci. (Med.)

Voronezh



E. M. Zaudenkova
Voronezh State Medical University named after N. N. Burdenko
Russian Federation

Zaudenkova Ekaterina Mikhailovna

Voronezh



D. S. Litvinova
Voronezh State Medical University named after N. N. Burdenko
Russian Federation

Litvinova Darya Sergeyevna

Voronezh



References

1. West Nile fever. Moscow: Ministry of Health of the Russian Federation, 2025. 58 p. (In Russ.).

2. Yushchuk N.D., Vengerov Yu.A., Alikeeva G.K. Infectious diseases. 2nd ed. Moscow: GEOTAR-Media, 2011 (In Russ.).

3. Kazantsev A.Yu., Zagidullina K.L., Akhmadieva L.A. et al. West Nile fever with the development of acute cochleovestibular pathology. Nervous Diseases, 2025, No. 1, рр. 117–122 (In Russ.). doi: 10.24412/2226-0757-2025-13246.

4. Kataev P.V., Timchenko L.V., Zotov S.V., Torgashova A.N., Sichinava D.K. A clinical case in neurological practice. Innovative Medicine of Kuban, 2021, Vol. 4, No. 24, рр. 63–66 (In Russ.).

5. Kokoreva S.P., Razuvaev O.A., Kotlova V.B. et al. West Nile fever in the Voronezh region in 2023. Treatment and Prevention, 2024, Vol. 14, No. 4, рр. 62–65 (In Russ.).

6. Krasavtsev E.L., Razuvanova I.A., Tereshkova M.E. The first case of diagnosis of West Nile fever in the Gomel region. Health Problems and Ecology, 2020, Vol. 1, No. 63, рр. 104–108 (In Russ.).

7. Molchanova E.V., Machneva A.Yu., Gerasimova A.D. et al. Predictors of the formation and functioning of natural foci of arbovirus infections in the Volgograd region. Bulletin of the Volgograd State Medical University, 2022, Vol. 19, No. 3, рр. 20–28 (In Russ.).

8. Istin A.A., Krasnorutskaya O.N., Shevtsova V.I., et al. Diagnostic possibilities for West Nile fever detection. Attending Doctor, 2025, Vol. 28, No. 11, рр. 63–68 (In Russ.). doi: 10.51793/OS.2025.28.11.008. EDN EHWNKQ.

9. stin A.A., Krasnorutskaya O.N., Bezlepkin A.S. et al. Aspects of the immune response to infection caused by the West Nile virus. Medical Alphabet, 2025, No. 16, рр. 64–67 (In Russ.). doi: 10.33667/2078-5631-2025-16-64-67.

10. Istin A.A., Krasnorutskaya O.N., Shevtsova V.I., Shevtsov A.N. Modeling of a rehabilitation program for patients with West Nile fever with cardiovascular complications in the aspect of endothelial function correction. Bulletin of the Bashkir State Medical University, 2025 No. 5, рр. 6–14 (In Russ.).

11. Lindenbach B.D., Rice C.M. Flaviviridae: the viruses and their replication // Knipe D.P., Howley P.M., eds. Fields Virology. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2007. Р. 1101–1152.

12. Gould E.A., Solomon T. Pathogenic flaviviruses // Lancet. 2008. Vol. 371, No. 9611. Р. 500–509.

13. Fiacre L., Pages N., Albina E. et al. Molecular determinants of West Nile virus virulence and pathogenesis in vertebrate and invertebrate hosts // Int. J. Mol. Sci. 2020. Vol. 21, No. 23. Р. 9117.

14. Subbotina E.L., Loktev V.B. Molecular evolution of West Nile virus. Molecular Genetics, Microbiology and Virology, 2014, No. 1, рр. 31–37 (In Russ.).

15. Nikitin D.N., Udovichenko S.K., Putintseva E.V., Toporkov A.V. West Nile fever: manifestations of the epidemic process in the world. Infectious Diseases: News, Opinions, Training, 2024, Vol. 4, No. 51, рр. 94–101 (In Russ.). doi: 10.33029/2305-3496-2024-13-4-94-101.

16. Toporkov A.V., Putintseva E.V., Udovichenko S.K. et al. Study of the circulation patterns and properties of the West Nile virus in Russia in 2022. Journal of Microbiology, Epidemiology and Immunobiology, 2024, Nо. 1, рр. 114–126 (In Russ.). doi: 10.36233/0372-9311-432.

17. Zhukov K.V., Toporkov A.V., Viktorov D.V. Epidemiological aspects and modern evolution of globally spreading arboviruses. Journal of Microbiology, Epidemiology and Immunobiology, 2018, No. 6, рр. 94–102 (In Russ.). doi: 10.36233/0372-9311-2018-6-94-102.

18. Molchanova E.V., Luchinin D.N., Machneva A.Yu. et al. Competence of Culex pipiens f. molestus mosquitoes as vectors of West Nile virus under various temperature conditions. Journal of Microbiology, Epidemiology and Immunobiology, 2022, No. 5, рр. 540–544 (In Russ.).

19. Putintseva E.V., Udovichenko S.K., Nikitin D.N. et al. Results of monitoring the pathogen in 2021 in the Russian Federation, forecast of morbidity for 2022. Problems of Especially Dangerous Infections, 2022, No. 1, рр. 43–53 (In Russ.). doi: 10.21055/0370-1069-2022-1-43-53.

20. Putintseva E.V., Udovichenko S.K., Nikitin D.N. et al. West Nile Fever in the Russian Federation in 2024, Forecast for 2025. Problems of Particularly Dangerous Infections, 2025, No. 1, рр. 84–95 (In Russ.). doi: 10.21055/0370-1069-2025-1-84-95.

21. Rossi S.L., Ross T.M., Evans J.D. West Nile virus // Clin. Lab. Med. 2010. Vol. 30, No. 1. Р. 47–65.

22. Molchanova E.V., Snigur G.L., Gerasimova A.D., Luchinin D.N., Gusev E.A. Combined infection with Sindbis virus and West Nile virus in an experiment. Infectious Diseases: News, Opinions, Training, 2022, Vol. 11, No. 2, рр. 77–84 (In Russ.). https://doi.org/10.33029/2305-3496-2022-11-2-77-84.

23. Toporkov A.V., Putintseva E.V., Udovichenko S.K. West Nile fever as an actual threat to health: history of study and prevention measures in Russia. Health Risk Analysis, 2023, Vol. 3, рр. 138–149 (In Russ.). doi: 10.21668/health.risk/2023.3.13.

24. Petersen L.R., Marfin A.A. West Nile virus: a primer for the clinician // Ann. Intern. Med. 2002. Vol. 137, No. 3. Р. 173–179.

25. Monastyrsky M.V., Demina Yu.V. The impact of climatic conditions on outbreak morbidity in the Russian Federation. National Priorities of Russia, 2024, Vol. 55, No. 4, рр. 138–142 (In Russ.).

26. Patyashina M.A., Sizova E.P., Avdonina L.G. et al. Epidemiological aspects of morbidity in the Republic of Tatarstan in 2023. Problems of Especially Dangerous Infections, 2024, Vol. 2, рр. 157–166 (In Russ.). doi: 10.21055/0370-1069-2024-2-157-166.

27. Safronov V.A., Smolenskij V.J., Smeljanskij V.P., Savchenko S.T., Razdorskij A.S., Toporkov V.P. Assessment of the dynamics of epidemic manifestations of West Nile fever in the Volgograd region depending on the climatic conditions preceding the start of the epidemic season. Virology issues, 2014, No. 59 (6), рр. 42–46 (In Russ.).

28. Habarugira G., Suen W.W., Hobson-Peters J., Hall R.A., Bielefeldt-Ohmann H. West Nile Virus: An Update on Pathobiology, Epidemiology, Diagnostics, Control and «One Health» Implications // Pathogens. 2020. Vol. 9, No. 7. Р. 589.

29. Klimova E.A., Karetkina G.N., Shakaryan A.K. et al. West Nile fever in the Moscow agglomeration. Infectious Diseases: News, Opinions, Training, 2021, Vol. 10, No. 4, рр. 13–21 (In Russ.). doi: 10.33029/2305-3496-2021-10-4-13-21.

30. Galimzyanov Kh.M., Mirekina E.V., Kuryatnikova G.K., et al. Modern clinical and epidemiological features of West Nile fever in the Astrakhan region. Astrakhan Medical Journal, 2018, Vol. 13, Nо. 4, рр. 124–130 (In Russ.). doi: 10.17021/2018.13.4.124.130.

31. Putintseva E.V., Udovichenko S.K., Borodai N.V. et al. Features of the epidemiological situation of West Nile fever in the Russian Federation in 2020 and forecast of its development in 2021. Problems of Especially Dangerous Infections, 2021, No. 1, рр. 51–60 (In Russ.). doi: 10.21055/0370-1069-2021-1-51-60.

32. dovichenko S.K., Putintseva E.V., Baturin A.A., Ryabnina L.A., Toporkov A.V. Results of a screening survey for West Nile fever markers among the population of the central and southern regions of Russia. Medical Herald of the South of Russia, 2024, Vol. 15, No. 1, рр. 74–81 (In Russ.). doi: 10.21886/2219-8075-2024-15-1-74-81.

33. Chekrygina E.V., Volynkina A.S., Zaitseva O.A., Lisitskaya Ya.V., Tishchenko I.V. et al. Molecular and epidemiological monitoring of pathogens of natural focal infections in the Stavropol Territory in 2016–2021. Epidemiology and Vaccination Prevention, 2023, Vol. 22, No. 4, рр. 24–34 (In Russ.). doi: 10.31631/2073-3046-2023-22-4-24-34.

34. Suthar M.S., Diamond M.S., Gale M. Jr. West Nile virus infection and immunity // Nat. Rev. Microbiol. 2013. Vol. 11, No. 2. Р. 115–128.

35. Diamond M.S., Gale M. Jr. Cell-intrinsic innate immune control of West Nile virus infection // Trends Immunol. 2012. Vol. 33, No. 10. Р. 522–530.

36. Fredericksen B.L. The neuroimmune response to West Nile virus // J. Neurovirol. 2014. Vol. 20, No. 2. Р. 113–121.

37. Peng B.H., Wang T. West Nile virus induced cell death in the central nervous system // Pathogens. 2019. Vol. 8, No. 4. Р. 215.

38. Luo H., Wang T. Recent Advances in Understanding West Nile Virus Host Immunity and Viral Pathogenesis // F1000Res. 2018. Vol. 7. Р. 338.

39. Daffis S., Samuel M.A., Suthar M.S. et al. Interferon Regulatory Factor IRF-7 Induces the Antiviral Alpha Interferon Response and Protects Against Lethal West Nile Virus Infection // J. Virol. 2008. Vol. 82, No. 16. Р. 8465–8475.

40. Thackray L.B., Shrestha B., Richner J.M. et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect Against West Nile Virus Infection // J. Virol. 2014. Vol. 88, No. 19. Р. 11007–11021.

41. Zimmerman M.G., Bowen J.R., McDonald C.E. et al. West Nile Virus Infection Blocks Inflammatory Response and T Cell Costimulatory Capacity of Human Monocyte-Derived Dendritic Cells // J. Virol. 2019. Vol. 93, Nо. 23. Р. e00664–19.

42. Quicke K.M., Suthar M.S. The innate immune playbook for restricting West Nile virus infection // Viruses. 2013. Vol. 5, No. 11. Р. 2643–2658.

43. Egemberdieva R.A., Shapieva Zh.Zh., Dmitrovskiy A.M. et al. West Nile fever: clinical and epidemiological manifestations. Bulletin of KazNMU, 2019, Vol. 2, рр. 18–19 (In Russ.).

44. Benzarti E., Murray K.O., Ronca S.E. Interleukins, chemokines, and tumor necrosis factor superfamily ligands in the pathogenesis of West Nile virus infection // Viruses. 2023. Vol. 15 Nо. 3. Р. 806.

45. Pan Y., Cai W., Cheng A., Wang M., Yin Z., Jia R. Flaviviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines // Front Immunol. 2022. Vol. 13. Р. 829433.

46. Samaan Z., McDermid Vaz S., Bawor M., Potter T.H., Eskandarian S., Loeb M. Neuropsychological Impact of West Nile Virus Infection: An Extensive Neuropsychiatric Assessment of 49 Cases in Canada // PLoS One. 2016. Vol. 11, Nо. 6. Р. e0158364.

47. Kazorina E.V., Sharova I.N., Zakharova N.B. et al. West Nile fever in the Saratov region in 2013–2015. Problems of Virology, 2017, Vol. 62, Nо. 5, рр. 219–224 (In Russ.). doi: 10.18821/0507-4088-2017-62-5-219-224.

48. Grigorieva N.V., Stolnova E.I. Pathomorphological features of West Nile fever: problems and prospects of study. Volgograd Scientific and Medical Journal, 2012, Nо. 1, рр. 75–77 (In Russ.).

49. Maletskaya O.V., Prislegina D.A., Taran T.V. et al. Natural focal viral fevers in the southern European part of Russia. West Nile fever. Problems of Especially Dangerous Infections, 2020, Nо. 1, рр. 109– 114 (In Russ.). doi: 10.21055/0370-1069-2020-1-109-114.

50. Negodenko A.O., Molchanova E.V., Prilepskaya D.R. et al. Analysis of the results of monitoring arbovirus infections in the Volgograd region in 2019. Epidemiology and Vaccination Prevention, 2021, Vol. 20, No. 1, рр. 51–59 (In Russ.).

51. Sambri V., Capobianchi M.R., Cavrini F. et al. Diagnosis of West Nile virus human infections: overview and proposal of diagnostic protocols considering the results of external quality assessment studies // Viruses. 2013. Vol. 5, Nо. 10, рр. 2329–2348.

52. Putintseva E.V., Alekseychik I.O., Chesnokova S.N. et al. Results of monitoring the West Nile fever pathogen in the Russian Federation in 2019 and forecast of the epidemic situation development in 2020. Problems of Especially Dangerous Infections, 2020, No. 1, рр. 51–60 (In Russ.).

53. Pichurina N.L., Moskvitina E.A. Arbovirus infections in the Rostov region. National Priorities of Russia, 2011, Vol. 2, Nо. 5, рр. 85–86 (In Russ.).

54. Putintseva E.V., Udovichenko S.K., Nikitin D.N., et al. West Nile fever: results of monitoring the pathogen in 2021 in the Russian Federation, forecast of morbidity for 2022. Problems of Especially Dangerous Infections, 2022, No. 1, рр. 43–53 (In Russ.). doi: 10.21055/0370-1069-2022-1-43-53.

55. oporkov A.V., Putintseva E.V., Udovichenko S.K. West Nile fever as an actual threat to health: history of study and prevention measures in Russia. Health Risk Analysis, 2023, No. 3, рр. 138–149 (In Russ.). doi: 10.21668/health.risk/2023.3.13.


Review

For citations:


Krasnorutskaya O.N., Rassokhin V.V., Shevtsova V.I., Istin A.A., Nasonova N.A., Zaudenkova E.M., Litvinova D.S. Сlinical and epidemiological characteristics, adverse consequences of West Nile fever. HIV Infection and Immunosuppressive Disorders. 2026;18(2):7-20. (In Russ.) https://doi.org/10.22328/2077-9828-2026-18-2-7-20

Views: 7

JATS XML


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2077-9828 (Print)