APPLICATION OF MILK THISTLE SCHROTH REDUCES A VIRAL LOAD IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C
https://doi.org/10.22328/2077-9828-2016-8-1-61-66
Abstract
The article presents the results of milk thistle schroth administration to reduce viral load in patients with chronic viral hepatitis С. These patients did not respond to combined antiviral therapy with peginterferon and ribavirin. Milk thistle schroth contains silymarin (a mixture of 7 compounds called flavolignans) and administrated at a dosage of 1 g/kg body weight in 39 patient, which is much higher than the dosages used in previous studies. 50 days after the administration of schroth in 28 patients (72% of all patients) there were a significant reduction of viral load and ALT activity to 5,1 times and 1,7 times, respectively. In
About the Authors
V. V. Sharoyko
Saint-Petersburg State University; First Pavlov State Medical University
Russian Federation
Russian Federation
A. G. Rakhmanova
First Pavlov State Medical University; Saint-Petersburg Center for Control of Infectious Diseases and AIDS
Russian Federation
Russian Federation
E. Y. Kolpashikova
Saint-Petersburg Center for Control of Infectious Diseases and AIDS
Russian Federation
Russian Federation
N. G. Zakharova
Saint-Petersburg Center for Control of Infectious Diseases and AIDS
Russian Federation
Russian Federation
A. G. Shevaldin
Saint-Petersburg Municipal out-patients clinic № 74
Russian Federation
Russian Federation
E. A. Zmaev
Louis Pasteur Pharmacological Association
Russian Federation
Russian Federation
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Review
For citations:
Sharoyko V.V., Rakhmanova A.G., Kolpashikova E.Y., Zakharova N.G., Shevaldin A.G., Zmaev E.A. APPLICATION OF MILK THISTLE SCHROTH REDUCES A VIRAL LOAD IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C. HIV Infection and Immunosuppressive Disorders. 2016;8(1):61-66. (In Russ.) https://doi.org/10.22328/2077-9828-2016-8-1-61-66
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