Preview

HIV Infection and Immunosuppressive Disorders

Advanced search

PHARMACOECONOMICS OF HIV TREATMENT WITH FIXED DOSE COMBINATIONS OF ANTIRETROVIRAL AGENTS

https://doi.org/10.22328/2077-9828-2014-6-1-97-100

Abstract

Ensuring adherence to HIV therapy - one of necessary conditions of increase of its efficiency. Treatment with once-daily regimens is preferable. Further it is possible to predict increase in a share of the fixed combinations in structure of consumption of antiretroviral agents in the Russian Federation. Thus it is necessary to consider that the fixed combinations of antiretrovirals in the first-line therapy permit to delay switching to expensive second-line regimens and reduce costs of hospitalization.

About the Author

A. V. Rudakova
Federal State Budgetary Institution «Scientific and research institute of children’s infections of Federal Medical and Biological Agency of Russia»
Russian Federation


References

1. Дворак С.И., Степанова Е.В., Сизова Н.В., Рассохин В.В., Малькова Т.В. Причины прекращения ВААРТ. Результаты длительного наблюдения за больными с ВИЧ-инфекцией // ВИЧ-инфекция и иммуносупрессии.- 2011.- Т. 3, № 3.- С. 52-57.

2. Покровский В.В., Юрин О.Г., Кравченко А.В., Покровский В.В., Юрин О.Г., Кравченко А.В., Беляева В.В., Канестри В.Г., Афонина Л.Ю., Ермак Т.Н., Буравцова Е.В., Шахгильдян В.И., Козырина Н.В., Нарсия Р.С., Зимина В.Н., Покровская А.В., Конов Д.С., Конов В.В., Голиусова М.А., Ефремова О.С., Попова А.А. Протоколы диспансерного наблюдения и лечения больных ВИЧ-инфекцией // Эпидемиология и инфекционные болезни. Актуальные вопросы.- 2012.- 6.- Р 1-48.

3. Raffi F., Reynes J. Antiretroviral treatment French guidelines 2013: economics influencing science // J. Antimicrob. Chemother. - 2013 doi: 10.1093/jac/dkt533.- URL: http://jac.oxfordjoumals.org/content/early/2014/01/16/jac.dkt533.abstract (дата обращения 20.02.2014 г.).

4. Williams I., Churchill D., Anderson J., Boffito M., Bower M., Cairns G., Edwards S., Fidler S., Fisher M., Freedman A., Geretti A.M., Gilleece Y., Horne R., Johnson M., Khoo S., Leen C., Marshall N., Nelson M., Orkin C., Paton N., Phillips A., Post F., Pozniak A., Sabin C., Trevelion R., Ustianowski A., Walsh J., Waters L., Wilkins E., Alan Winston, Youle M. Winston, Dr Mike Youle. BHIVA guidelines for the treatment of HIV-1 positive adults with antiretroviral therapy 2012 // HIV Med.- 2012.- 13 Suppl 2.- Р. 1-85.

5. Thompson M.A., Aberg J.A., Hoy J.F., Telenti A., Benson C., Cahn P., Eron J.J., G?nthard H.F., Hammer S.M., Reiss P., Richman D.D., Rizzardini G., Thomas D.L., Jacobsen D.M., Volberding P.A. Antiretroviral treatment of adult HIV infection. 2012 Recommendations of the International Antiviral Society-USA Panel // JAMA 2012.- Vol. 308.- Р. 387-402.

6. Ministere des Affaires Sociales et de la Sante, Conseil National du Sida, Agence Nationale de Recherches sur le SIDA et les Hepatites Virales. Prise en Charge Medicale des Personnes Vivant Avec le VIH. Recommandations du Groupe d’Experts. Rapport 2013. - 95 р. - URL: http://www.sante.gouv.fr/IMG/pdf/Rapport_Morlat_2013_Mise_en_ligne.pdf. (дата обращения 12.02.2014 г.).

7. European AIDS Clinical Society. Guidelines, version 7.0, October 2013.- URL: http://www.eacsociety.org/Portals/0/ Guidelines_Online_131014.pdf. (дата обращения 08.02.2014 г.).

8. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents, 15 Feb 2013.- URL:http://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. (дата обращения 12.02.2014 г.).

9. Recommendation on Integrase Inhibitor Use in Antiretroviral Treatment-Naive HIV-Infected Individuals from the HHS Panel on Antiretroviral Guidelines for Adults and Adolescents.- URL:http://aidsinfo.nih.gov/contentfiles/AdultARV_INSTIRecommendations.pdf.

10. Bangalore S., Kamalakkannan G., Parkar S., Messerli F. Fixed-dose combinations improve medication compliance: a meta-analysis // Am. J. Med.- 2007.- 120 (8).- Р. 713-719.

11. Кытманова Л.Ю., Дегтярев А.А. Факторы, определяющие приверженность к терапии у больных с ВИЧ-инфекцией // ВИЧ-инфекция и иммуносупрессии 2013.- Т. 5 (3).- С. 100-107.

12. Maitland D., Jackson A., Osorio J., Mandalia S., Gazzard B.G., Moyle G.J. Switching from twice-daily abacavir and lamivudine to the once-daily fixed-dose combination tablet of abacavir and lamivudine improves patient adherence and satisfaction with therapy // HIV Med.- 2008.- 9 (8).- Р 667-672.

13. Willig J., Abroms S., Westfall A., Routman J., Adusumilli S., Varshney M., Allison J., Chatham A., Raper J.L., Kaslow R.A., Saag M.S., Mugavero M.J. Increased regimen durability in the era of once-daily fixed-dose combination antiretroviral therapy // AIDS.- 2008.- 22 (15).- Р 1951-1960.

14. Cohen C.J., Meyers J.L., Davis K.L. Association between daily antiretroviral pill burden and treatment adherence, hospitalisation risk, and other healthcare utilisation and costs in a US medicaid population with HIV // BMJ Open.- 2013.- 3.- e003028. doi:10.1136/bmjopen-2013-003028. (дата обращения 12.02.2014 г.).

15. Buscher A., Hartman C., Kallen M., Giordano T. Impact of antiretroviral dosing frequency and pill burden on adherence among newly diagnosed, antiretroviral-naive HIV patients // International Journal of STD & AIDS.- 2012.- Vol. 23.- Р 351-355.


Review

For citations:


Rudakova A.V. PHARMACOECONOMICS OF HIV TREATMENT WITH FIXED DOSE COMBINATIONS OF ANTIRETROVIRAL AGENTS. HIV Infection and Immunosuppressive Disorders. 2014;6(1):97-100. (In Russ.) https://doi.org/10.22328/2077-9828-2014-6-1-97-100

Views: 1039


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2077-9828 (Print)