MOLECULAR EPIDEMIOLOGY OF HEPATITIS B VIRUS GENOTYPES ISOLATED IN BELARUS
https://doi.org/10.22328/2077-9828-2016-8-4-43-54
Abstract
The objective of the present work was to study the dissemination pathways of specific hepatitis B virus (HBV) genotypes and their subtypes and to determine the genetic interrelationships of HBV in patients ascribed to different risk factors of HBV infection in different regions of the Republic of Belarus. The molecular-epidemiological characteristics of HBV subtypes were determined using the phylogenetic analysis of the P region of viral genome. Possible HBV entry and dissemination pathways in different areas of Belarus were inferred. The comparison of genetically related HBV variants and reference sequences from different parts of the world shows that the D2, D3 and D4 subtypes of HBV from patients in Belarus form significantly different clusters. The data suggest that these variants spread predominantly via domestic pathways. The A2 and D1 subtypes disseminated independently via HBV entries from epidemiologically independent sources. The C2 and B4 subtypes originate from Southeast Asia and circulate among migrants from this area. Phylogenetic analysis made it possible to obtain objective information about the development of viral hepatitis B in the Republic of Belarus.
About the Authors
E. L. Gasich
The Republican Research and Practical Center for Epidemiology and Microbiology
Russian Federation
Russian Federation
V. F. Eremin
The Republican Research and Practical Center for Epidemiology and Microbiology
Russian Federation
Russian Federation
A. S. Nemira
The Republican Research and Practical Center for Epidemiology and Microbiology
Russian Federation
Russian Federation
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Review
For citations:
Gasich E.L., Eremin V.F., Nemira A.S. MOLECULAR EPIDEMIOLOGY OF HEPATITIS B VIRUS GENOTYPES ISOLATED IN BELARUS. HIV Infection and Immunosuppressive Disorders. 2016;8(4):43-54. (In Russ.) https://doi.org/10.22328/2077-9828-2016-8-4-43-54
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