ПРОБЛЕМЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ СИФИЛИСА ПРИ КОИНФЕКЦИИ ВИРУСОМ ИММУНОДЕФИЦИТА ЧЕЛОВЕКА
https://doi.org/10.22328/2077-9828-2018-10-2-43-53
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Аннотация
Обзорная статья посвящена особенностям диагностики и лечения сифилиса, развивающегося на фоне ВИЧ-инфекции. У небольшого числа ВИЧ-инфицированных больных могут отмечаться ложноотрицательные и ложноположительные результаты серологических реакций на сифилис. Пациенты с коинфекцией подвержены более высокому риску возникновения специфических поражений нервной системы, органов зрения и слуха, у них выше вероятность неудач в лечении сифилиса и возникновения нейрорецидивов. Эффективность терапии нейросифилиса на фоне коинфекции трудно оценить, так как нормализация состава СМЖ у ВИЧ-позитивных пациентов происходит медленнее, чем у ВИЧ-негативных. В ближайшие годы число случаев сочетанных заражений сифилисом и ВИЧ-инфекцией будет неминуемо увеличиваться. В связи с этим необходимо всестороннее изучение проблемы коинфекции и совершенствование подходов к ведению больных на основе принципов доказательной медицины.
Об авторах
Т. В. Красносельских
ФГБОУ ВО ПСПбГМУ им. И.П.Павлова Минздрава России
Россия
Россия
Красносельских Татьяна Валерьевна — доктор медицинских наук, профессор кафедры дерматовенерологии с клиникой
197022, Санкт-Петербург, ул. Льва Толстого, 6–8, корп. 4
Е. Б. Манашева
ФГБОУ ВО ПСПбГМУ им. И.П.Павлова Минздрава России
Россия
Россия
Манашева Елизавета Борисовна — старший лаборант кафедры дерматовенерологии с клиникой
197022, Санкт-Петербург, ул. Льва Толстого, 6–8, корп. 4
М. А. Гезей
СПб ГБУЗ «Центр СПИД и инфекционными заболеваний»
Россия
Россия
Гезей Мария Александровна — врач
190103, СанктПетербург, наб. Обводного канала, 179
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Рецензия
Для цитирования:
Красносельских Т.В., Манашева Е.Б., Гезей М.А. ПРОБЛЕМЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ СИФИЛИСА ПРИ КОИНФЕКЦИИ ВИРУСОМ ИММУНОДЕФИЦИТА ЧЕЛОВЕКА. ВИЧ-инфекция и иммуносупрессии. 2018;10(2):43-53. https://doi.org/10.22328/2077-9828-2018-10-2-43-53
For citation:
Krasnoselskikh T.V., Manasheva E.B., Gezei M.A. DIAGNOSIS AND TREATMENT OF SYPHILIS IN PATIENTS COINFECTED WITH HUMAN IMMUNODEFICIENCY. HIV Infection and Immunosuppressive Disorders. 2018;10(2):43-53. (In Russ.) https://doi.org/10.22328/2077-9828-2018-10-2-43-53
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