Широко нейтрализующие антитела для лечения ВИЧ-инфекции
https://doi.org/10.22328/2077-9828-2021-13-3-
Аннотация
Антитела, обладающие нейтрализующей активностью в отношении широкого спектра субтипов вируса иммунодефицита человека 1 (обозначаемые термином broadly neutralizing antibodies (bnAbs)), представляют огромный интерес в качестве терапевтического агента для лечения ВИЧ-инфекции, поскольку при пассивной иммунизации они способны обеспечить защиту от большинства штаммов ВИЧ-1. В представленном обзоре обсуждаются механизмы формирования таких антител, их классификация по связыванию с консервативными областями оболочечного белка Env, а также присущие им особенности. Приведены данные по характеристикам наиболее перспективных для терапии bnAbs, а также их комбинаций. В последнем разделе подробно рассмотрены результаты проведенных на сегодняшний день клинических испытаний.
Об авторах
Дина Викторовна ГлазковаРоссия
кандидат биологических наук, старший научный сотрудник
Елена Владимировна Богословская
Россия
доктор медицинских наук, заведующий лабораторией разработки методов генной терапии
Герман Александрович Шипулин
Россия
кандидат медицинских наук, заместитель директора по научно-производственной деятельности
Сергей Михайлович Юдин
Россия
доктор медицинских наук, профессор, генеральный директор ФГБУ ЦСП ФМБА России
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Для цитирования:
Глазкова Д.В., Богословская Е.В., Шипулин Г.А., Юдин С.М. Широко нейтрализующие антитела для лечения ВИЧ-инфекции. ВИЧ-инфекция и иммуносупрессии. 2021;13(3). https://doi.org/10.22328/2077-9828-2021-13-3-
For citation:
Glazkova D.V., Bogoslovskaya E.V., Shipulin G.A., Yudin S.M. Broadly neutralizing antibodies for the treatment of HIV infection. HIV Infection and Immunosuppressive Disorders. 2021;13(3). https://doi.org/10.22328/2077-9828-2021-13-3-
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