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Assessment of the severity of the condition of patients with acute substance poisoning using the PSS scale

https://doi.org/10.22328/2077-9828-2023-15-1-60-66

Abstract

Objective. To determine the effectiveness and introduce the Poisoning Severity Score (PSS) scale into the clinical practice of the department for patients with acute poisoning with psychoactive substances.

Materials and methods. A single–center retrospective and prospective randomized clinical trial was conducted in 200 patients with acute poisoning with the psychostimulant alpha-pyrrolidinopentiophenone and the synthetic cannabinoid MDMB–FUBINACA. To assess the severity of substance poisoning, the Poisoning Severity Score (PSS) scale developed by the European Association of Clinical Toxicologists IPCS/EC/EAPCCT was used.

Results and discussion. This scale allows to objectify clinical and laboratory manifestations of acute poisoning with psychodisleptics, to identify the leading syndromes, to predict the risk of complications and emergency conditions.

Conclusion. The PSS scale is easy to use and does not require a wide range of diagnostic capabilities from a medical institution, helps to determine the tactics of patient management and determines the volume of emergency care at the hospital stage.

About the Authors

A. N. Lodyagin
St. Petersburg Research Institute of Emergency Medicine named after I. I. Dzhanelidze
Russian Federation

St. Petersburg



E. A. Rakhmanova
Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation

St. Petersburg



A. G. Miroshnichenko
St. Petersburg Research Institute of Emergency Medicine named after I. I. Dzhanelidze; North-Western State Medical University named after I. I. Mechnikov; Pavlov First State Medical University St. Petersburg
Russian Federation

St. Petersburg



References

1. Dolgareva S.A., Sorokin A.V., Konoplya N.A., Bushmina O.N., Bystrova N.A., Gadfly A.I. The use of immunomodulators, antioxidants and hepatoprotectors for the correction of disorders in the liver, erythrocytes and the immune system in chronic ethanol intoxication. Biomedical chemistry, 2018, Vol. 64, No. 4, pp. 360–367 (In Russ.).

2. Safarov Z.F., Abdullaev K.G., Shoikramov Sh.Sh., Alimov A.A. Comparison of the results of different integral evaluation systems for assessing the severity of critical conditions in children. Problems of modern science and education, 2018, No. 7 (127), рp. 90–97 (In Russ.).

3. Griffiths P., Sedefov R., Gallegos A., Lopez D. How globalization and market innovation challenge how we think about and respond to drug use: «Spice» a case study // Addiction. 2010. Vol. 105, No. 6. P. 951–953. doi: 10.1111/j.1360-0443.2009.02874.x

4. Hillebrand J., Olszewski D., Sedefov R. Legal highs on the internet // Subst. Use Misuse. 2010. Vol. 45, No. 3. P. 330–340.

5. Hopkins C.Y., Gilchrist B.L. A case of cannabinoid hyperemesis syndrome caused by synthetic cannabinoids // J. Emerg. Med. 2013. Vol. 45, No. 4. P. 544–546.

6. Stellpflug S.J., Kealey S. E., Hegarty C.B., Janis G.C. 2-(4-iodo-2,5dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl] ethanamine (25INBOMe): clinical case with unique confirmatory testing // J. Med. Toxicol. 2014. Vol. 10, No. 1. P. 45–50. doi: 10.1007/s13181-013-0314-y.

7. Lodyagin A.N., Rakhmanova E.A., Popova E.A., Batotsyrenov B.V., Popov A.A., Bolshakova M.A., Rakhmanov R.M. Improvement of intensive therapy in patients with acute poisoning with psychodisleptics. Journal of Siberian Medical Sciences, 2020, No. 3, pp. 39–51 (In Russ.).

8. Lodyagin A.N., Rakhmanova E.A., Popova E.A., Batotsyrenov B.V., Popov A.A., Bolshakova M.A., Rakhmanov R.M. Optimization of treatment of acute poisoning with severe psychodisleptics. Journal of Neurology and Psychiatry named after S. S. Korsakov, 2020, Vol. 120, No. 9, рp. 60–65 (In Russ.).

9. Burtsev A.A., Iskandarov R.R., Smirnov A.V., Petukhov A.V., Nenastieva A.Yu. Some actual problems of monitoring new psychoactive substances in Moscow. Narcology, 2018, Vol. 17, No. 6, pp. 53–59 (In Russ.).

10. Sinevich A.A., Kopytov A.V. Analysis of productive symptoms on the scale of positive symptoms of PANSS, in males with dependence on smoking mixtures from the Republic of Belarus. Military medicine, 2016, No. 3, pp. 64–70 (In Russ.).

11. Brent J., Burkhart K., Dargan P., Hatten B. Critical Care Toxicology. Diagnosis and Management of the Critically Poisoned Patient. Elsevier Mosby, 2017. 1690 p.

12. Coppola M., Mondola R. 5-Iodo-2-aminoindan (5-IAI): chemistry, pharmacology, and toxicology of a research chemical producing MDMA-like effects // Toxicol. Lett. 2013. Vol. 218, No. 1. P. 24–29.

13. Poklis J.L., Devers K.G., Arbefeville E.F., Pearson J.M., Houston E., Poklis A. Postmortem detection of 25I-NBOMe [2-(4-iodo-2,5- dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine] in fluids and tissues determined by high performance liquid chromatography with tandem mass spectrometry from a traumatic death // Forensic Sci. Int. 2014. Vol. 234. P. e14–e20. doi: 10.1016/j.forsciint.2013.10.015

14. Vandrey R., Dunn K.E., Fry J.A., Girling E.R. A survey study to characterize use of Spice products (synthetic cannabinoids) // Drug Alcohol Depend. 2012. Vol. 120, No. 1–3. P. 238–241 1016/j.drugalcdep.2011.07.011.

15. Weaver M.F., Hopper J.F., Gunderson E.W. Оценка и оказание помощи // Вопросы наркологии. 2016. № 1. С. 76–96. [Weaver M.F., Hopper J.F., Gunderson E.W. Assessment and assistance. Issues of narcology, 2016, No. 1, pp. 76–96 (In Russ.)].


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For citations:


Lodyagin A.N., Rakhmanova E.A., Miroshnichenko A.G. Assessment of the severity of the condition of patients with acute substance poisoning using the PSS scale. HIV Infection and Immunosuppressive Disorders. 2023;15(1):60-66. (In Russ.) https://doi.org/10.22328/2077-9828-2023-15-1-60-66

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