Results of treatment of patients with HIV infection in Russia, 2016-2022

The aim. To study the results of treatment of patients with HIV infection in Russia and the subjects of the Russian Federation in dynamics for the period from 2016 to 2022.

Materials and methods. Information from the Federal Statistical Observation Form No. 61 for 2016–2022. To find correlations between the indicators characterizing the number of patients with HIV infection who were under dispensary supervision, covered by antiretroviral therapy (ART) and achieved virological suppression, data from 85 subjects of the Russian Federation (RF) for 2016–2022 were used.

Jupiter Notebook interactive computing environment (6.5.2) was used to work with data from 85 subjects of the Russian Federation for the period from 2016 to 2022. Pandas software library (1.5.3) was used for data processing and analysis, compilation and work with structured dataset. The Scipy statistical function module (1.9.3) was used to find the Spearman and t-Kendall correlation coefficients. The Scikit-learn (1.0.2) and Statsmodels (0.13.5) software libraries were used to build a trend line and find linear regression coefficients.

Results and discussion. The study of the relationship between the number of patients with HIV infection who were registered at the dispensary (HIV-infected contingents) and who received ART in 85 subjects of the Russian Federation in 2016–2022 showed that in 2016 the share of subjects of the Russian Federation with low coverage of ART of HIV-infected contingents was 38.8% of their total number. However, by the end of 2022, in all 85 regions of the Russian Federation, contingents with HIV infection were proportionally covered by ART.

An analysis of the distribution of 85 subjects of the Russian Federation in 2016–2022, depending on the relationship between the natural logarithms of the number of HIV-infected contingents who achieved virological suppression (effective ART) with the number of contingents covered by ART, revealed 11 subjects of the Russian Federation in which the percentage change in the number of contingents with effective ART exceeded the calculated value and did not correspond to the percentage changes in the number of contingents covered by ART. The results indicated the presence of defects in assessing the effectiveness of the treatment, since in these subjects of the Russian Federation the number of contingents with effective ART exceeded the number of contingents covered by ART. In 18 subjects of the Russian Federation, on the contrary, the percentage change in the number of HIV-infected patients with effective ART was lower than the calculated value and did not correspond to the percentage change in the number of patients covered by ART, that is, the effectiveness of the treatment was insufficient.

Conclusion. Currently, there is an urgent need in Russia to develop a methodology and criteria for evaluating the results and effectiveness of treatment of patients with HIV infection.

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