ANALYSIS OSNONYE CAUSE OF DEATH IN HIV-INFECTED PATIENTS

Abstract

In recent years, the nature of the HIV epidemic has changed towards comorbid and severe forms of the disease. HIV infection
remains the leading cause of death in young people. The level of mortality from advanced stages of the disease, reflects the level
of organization of medical care for such patients.

The aim of the study is to analyze the main causes of deaths in HIV-infected
patients on treatment in a specialized department, taking into account the stage of the disease, secondary and concomitant
pathology.

Мaterials and methods. Аnalysis of statistical form № 61, «Information on contingents of patients with HIV infection» and a retrospective analysis of 143 cases of deceased patients admitted to the hospital of the GOU «Novgorod Regional Infectious Disease Hospital» for the period from 2004 to 2016 were carried out.

The conclusion. In the Novgorod region, the number of people  infected with HIV is increasing every year, and the number of  hospitalizations is increasing, among which there is an increase in the patient’s condition. Late detected cases of HIV infection among the deceased were 14,68%. In late diagnosed patients,  tanatogenesis was preobdali: pneumocystis pneumonia, generalized  tuberculosis, CNS involvement (including one-third of tuberculosis  and one-third of toxoplasmic etiology). 19% of patients had a  combination of two or more AIDS-associated diseases. In 69,2% of patients, several comorbid diseases were observed, which occurred against a background of severe concomitant pathology. In terms of  CD4-lymphocyte content in the blood, the main causes of death  were distributed in the following order: chronic hepatitis in the cirrhotic stage (highest CD4-lymphocyte counts), pneumonia, tuberculosis, cytomegalovirus infection, sepsis, cryptococcosis,  pneumocystic pneumonia, cerebrospiration (the lowest indices CD4 lymphocytes).