SECONDARY DISEASES IN TANATOGENESIS IN HIV INFECTION
https://doi.org/10.22328/2077-9828-2019-11-1-46-55
Abstract
The problem of HIV infection has not lost its relevance, despite the progress and deepening of our knowledge about the disease over the years of study. The paper reflects the detailed structure of lethal outcomes and secondary diseases in HIV infection, taking into account in-depth histological studies in three time periods (1996/97, 2006, 2016) on the basis of these protocols of pathoanatomical autopsies in S.P.Botkin. Some of the data obtained confirms the facts known from the literature, while others are new and need further in-depth study. An important aspect of the work was the assessment of the significance of individual diseases in the tanatogenesis of each case, taking into account all clinical, laboratory and morphological data. The range of HIV-associated diseases varied in different time periods, although in many cases it was insignificant. In general, during the 20-year period of time HIV infection has undergone significant pathomorphosis.
About the Authors
E. G. Koshevaya
Saint-Petersburg University
Russian Federation
Russian Federation
V. A. Zinserling
Saint-Petersburg University;
Center of Infectious Pathology at S.P.Botkin Clinical Infectious Hospital;
Federal Research Scientific Medical Center named after V.A.Almazov
Russian Federation
Russian Federation
References
1. HIV 2014/2015. Ed. K.Hoffman and J.K.Rockstroh. Hamburg: Medizin Fokus, 2014, 942 p. (In Russ.).
2. Pokrovsky V.V. HIV infection and AIDS: National leadership. Moscow: GEOTAR-Media, 2013, 608 p. (In Russ.)
3. UNAIDS data 2017. Geneva: UNAIDS, 2017 URL: http://www.unaids.org/en/dataanalysis/knowyourepidemic/epidemiologypublications (April 30, 2018).
4. Belyakov N.A., Vinogradova T.N., Rosenthal V.V., Sizova N.V., Rassokhin V.V., Lisitsyna Z.N., Panteleeva O.V., Dvorak S.I. Evolution of the epidemic of HIV infection in Saint-Petersburg — reduce illness, aging and aggravation of diseases. HIV Infection and Immunosuppressive Disorders, 2015, Vol. 7, No. 2, pp. 7–17 (In Russ.).
5. Parkhomenko Yu.G., Zyuzya Yu.R. Basic principles of formulation of pathoanatomical diagnosis of HIV infection. Archives of Pathology, 2013, No. 6, pp. 44–47 (In Russ.).
6. Zimina V.N., Kravchenko A.V., Zyuzya Yu.R., Batyrov F.A., Popova A.A., Parkhomenko Yu.G. Features of the course of tuberculosis in combination with other secondary diseases in patients with HIV infection. HIV Infection and Immunosuppressive Disorders, 2011, Vol. 3, No. 3, pp. 45–51 (In Russ.).
7. Zyuzya Yu.R., Parkhomenko Yu.G., Mozgaleva N.V. Clinical and morphological observation of combined tuberculosis and cytomegalovirus lung lesions in HIV infection. Pulmonology, 2011, No. 6, pp. 117–119 (In Russ.).
8. Tsinzerling V.A. The most Important problems of morphological diagnosis of HIV infection. HIV Infection and Immunosuppressive Disorders, 2009, No. 2, pp. 31–37 (In Russ.).
9. Tsinzerling V.A., Komarova D.V., Rakhmanova A.G., Yakovlev A.A., Leonova O.N. Actual problems of morphological diagnostics and pathomorphism of HIV infection. Archives of Pathology, 2010, No. 2, pp. 26–30 (In Russ.).
10. Chang C.C., Crane M., Zhou J., Mina M., Post J.J., Cameron B.A., Lloyd A.R., Jaworowski A., French M.A., Lewin S.R. HIV and co-infections. Immunol. Rev., 2013, Vol. 254, No. 1, pp. 114–142.
11. Vyaltsin S.V., Kalinina E.A. Analysis of mortality of HIV-infected in the Orenburg region in the period 2006–2010. HIV Infection and Immunosuppressive Disorders, 2012, Vol. 4, No. 3, pp. 87–91 (In Russ.).
12. Golokhvastova E., Tsarenko S., Litvinova N., Peregudova A., Leonova T., Shakhgildyan V., Olshansky A., Mazus A. Spectrum and frequency of opportunistic infections in patients with HIV infection. Vrach, 2012, No. 6, pp. 26–30 (In Russ.).
13. Lioznov D.A., Dessau M.I., Antonova T.V., Nikolaenko S.L. Causes of death in HIV-infected patients in the Lomonosov district of the Leningrad oblast in 1999–2011. Journal of Infectology, 2015, Vol. 7, No. 3, pp. 54–58 (In Russ.).
14. Mikhailova N.R., Mikhailovsky A.M., Vyaltsin S.V., Kalinina T.N. Characteristics of deaths of patients with HIV infection at the AIDS stage in Orenburg in 2012. Bulletin OGU, 2013, Vol. 1 (162), pp. 130–135 (In Russ.).
15. Rakhmanova A.G., Yakovlev A.A., Dmitrieva M.I., Vinogradova T.N., Kozlov A.A. Analysis of the causes of death of HIV-infected in 2008–2010 based on the materials of the clinical infectious diseases hospital S.P.Botkin, Saint-Petersburg. Kazan Medical Journal, 2012, Vol. 93, No. 2, pp. 522–526 (In Russ.).
16. Yugay O.Yu., Kytmanova L.Yu. Features of registration of lethal cases in patients with HIV infection. Bulletin of Young Scientists and Specialists of the Chelyabinsk Region, 2016, Vol. 2, No. 3 (14), pp. 83–85 (In Russ.).
17. Yakovlev A.A., Musatov V.B., Savchenko M.A. Causes of death in HIV-infected patients receiving antiretroviral therapy. HIV Infection and Immunosuppressive Disorders, 2015, Vol. 7, No. 1, pp. 84–89 (In Russ.).
18. Zyuzya Yu.R., Parkhomenko Yu.G., Zimina V.N., Tishkevich O.A. Morphological features of pneumocystic pneumonia in HIV infection. Pulmonology, 2012, No. 5, pp. 56–61 (In Russ.).
19. Uno K., Konishi M., Yoshimoto E., Kasahara K., Mori K., Maeda K., Ishida E., Konishi N., Murakawa K., Mikasa K. Fatal cytomegalovirus-associated adrenal insufficiency in an AIDS patient receiving corticosteroid therapy. Intern. Med., 2007, Vol. 46, No. 9, pp. 617–620.
20. Pivnik A.V., Tumanova M.V., Seregin N.V., Parkhomenko Yu.G., Tishkevich O.A., Kovrigina A.M., Likunov E.B. Lymphoma in HIV: a literature review. Clinical Oncohematology, 2014, Vol. 7, No. 3, pp. 264–277 (In Russ.).
21. Shiels M.S., Engels E.A. Evolving epidemiology of HIV-associated malignancies. Current opinion in HIV and AIDS, 2017, Vol. 12, No. 1, pp. 6–11.
Review
For citations:
Koshevaya E.G., Zinserling V.A. SECONDARY DISEASES IN TANATOGENESIS IN HIV INFECTION. HIV Infection and Immunosuppressive Disorders. 2019;11(1):46-55. (In Russ.) https://doi.org/10.22328/2077-9828-2019-11-1-46-55
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