The role of cytomegalovirus infection in the development of the nervous system lesions and retinitis in people living with HIV
https://doi.org/10.22328/2077-9828-2020-12-2-89-96
Abstract
Purpose: identification of patients with manifest forms of CMVI among PLHIV with neurological manifestations and eye lesions.
Materials and methods: 85 patients with CD4 less than 330 cells were examined who quantified CMV DNA in blood leukocytes. Patients depending on CD4 were divided into 2 groups: group 1 — patients with values of CD4<00 cells (n=42) and group 2 — patients with values of CD4 from 101 to 330 cells (n=43). According to indications, the patient underwent lumbar puncture followed by determination of CMV DNA in the cerebrospinal fluid.
Results and discussion: There were 20 patients in the III clinical stage (23,5%) and 65 (76,5%) in the IV clinical stage. VL CMV among patients with CD4 less than 100 cells was positive in 52,4%, and with CD4 more than 101 cells in 18,6%. VL CMV of less than 1000 copies was detected in 23,8% in patients with CD4 less than 100 cells and in 16,3% in patients with CD4 101–330 cells. The diagnosis of CMV retinitis was made in 6 out of 21 patients (28,6%) with CMV DNA in the blood. CMV DNA in CSF was determined in 3 patients. Half of 42 patients (52,4%) with severe and final stages of cognitive and motor impairment showed a generalized form of CMVI. Physical, clinical and biochemical parameters are not highly informative for determining the generalization of CMVI.
About the Authors
R. I. Kasimova
Research Institute of Virology
Uzbekistan
Uzbekistan
Kasimova Rano I.
Tashkent
N. E. Musabaeva
Research Institute of Virology
Uzbekistan
Tashkent
Uzbekistan
Tashkent
R. Z. Pulatova
Research Institute of Virology
Uzbekistan
Tashkent
Uzbekistan
Tashkent
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Review
For citations:
Kasimova R.I., Musabaeva N.E., Pulatova R.Z. The role of cytomegalovirus infection in the development of the nervous system lesions and retinitis in people living with HIV. HIV Infection and Immunosuppressive Disorders. 2020;12(2):89-96. (In Russ.) https://doi.org/10.22328/2077-9828-2020-12-2-89-96
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