Аnalysis of cases of progressive multifocal leukethephalopathy in patients with HIV infection: clinical, epidemiological, diagnostic and therapeutic aspects of the problem
A. B. Konkova-Reidman,
T. V. Mikheeva,
A. A. Veksey,
N. V. Smirnova,
Yu. Y. Ermolenko,
M. V. Radzikhovskaya https://doi.org/10.22328/2077-9828-2020-12-4-81-86
Abstract
Purpose of research. Study of epidemiological, clinical, diagnostic and therapeutic features of progressive multifocal leukoencephalopathy in HIV-infected patients.
Materials and methods. We analyzed 10 cases of deaths from PML of patients with HIV infection according to the reports of the Magnitogorsk AIDS Center for 2014–2016, and provided our own clinical observation of a patient with PML who was treated in 1 infectious Department of the South Ural State Medical University of the Ministry of Health of Russia in 2018 year.
Results and discussion. In most cases of PML observed with CD4+ less than 50 cells and a viral load of more than 150 000 HIV RNA copies/ml, brain MRI is an informative method of in vivo diagnosis, WARTH slows the progression and improves the prognosis of patients.
About the Authors
A. B. Konkova-Reidman
Federal State Budgetary Educational Institution of Higher Education Clinic of the South Ural State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Alena В. Konkova-Reidman
Chelyabinsk
T. V. Mikheeva
Federal State Budgetary Educational Institution of Higher Education Clinic of the South Ural State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Tatyana V. Mikheeva
Chelyabinsk
A. A. Veksey
Federal State Budgetary Educational Institution of Higher Education Clinic of the South Ural State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Anna А. Veksey
Chelyabinsk
N. V. Smirnova
Federal State Budgetary Educational Institution of Higher Education Clinic of the South Ural State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Nadezhda V. Smirnova
Chelyabinsk
Yu. Y. Ermolenko
City Hospital No. 1 named after G. I. Drobyshev, Magnitogorsk
Russian Federation
Russian Federation
Yuliya Y. Ermolenko
Magnitogorsk
M. V. Radzikhovskaya
Regional Center for the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Russian Federation
Margarita V. Radzikhovskaya
Chelyabinsk
References
1. Hoffman К., Rokshtro Yu.K. HIV Treatment 2009. Moscow: Рublishing house R.Valent, 2010, 648 р. (In Russ.).
2. Padgett B., Walker D., Zu Rhein G., Eckroade R., Dessel B. Cultivation of papovalike virus from human brain with progressive multifocal leukoencephalopathy // Lancet. 1971. Vol. 29. P. 1257–1260.
3. Astrom K., Mancall E., Richardson E. Progressiv multifocal leucoencephalopathy: a hithero unrecognized complication of chronic lymphatic leukemia and Hodgkin,s disease // Brain. 1958. Vol. 81. P. 93–111.
4. Belov B.S. Progressive multifocal leukoencephalopathy: rheumatological aspects. Modern rheumatology, 2015, Vol. 9 (3), рр. 4–9 (In Russ.).
5. Belozerov E.S., Bulankov Yu.I., Tapbergenov T.S. Slow infections. Pavlodar: NPF ECO, 2005, 480 p. (In Russ.).
6. Zakharova M.N. Progressive multifocal leukoencephalopathy (literature review). Journal of Neurology and Psychiatry named after S.S.Korsakov. Special issues, 2012, Vol. 112 (9), рр. 29–33 (In Russ.).
7. Proskura L.V. A case of progressive multifocal leukoencephalopathy (PML) in a patient with combined HIV pathology and tuberculosis. Science and healthcare, 2013, Vol. 1, рр. 71–72 (In Russ.).
8. Kornienko V.I., Pronin I.N. Diagnostic neuroradiology. Moscow: Publishing house «Andreeva T.M.», 2006, 1327 р. (In Russ.).
9. Weber T. Progressive multifocal leukoencephalopathy // Neurol. Clin. 2008. Vol. 26. P. 833–854.
10. Bossollasco S., Calori G., Moretti F., Boschini A., Bertelli D., Mena M., Gerevini S., Bestetti A., Pedale R., Sala S., Sala St., Lazzarin A., Cinque P. Prognostic significance of JS virus DNA levels in cerebrospinal fluid of patients with HIV-associated progressive multifocal leukoencephalopathy // Clin. Infect. Dis. 2005. Vol. 40. Р. 738–744.
11. Valieva D.I., Puzyreva L.V. Multifocal leukoencephalopathy in HIV-infected patients. Crimean therapeutic journal, 2017, No. 2, рр. 50–54 (In Russ.).
12. Huang D., Cossoy M., Li M., Choi D., Tag A., Staugaitis Susan M., Rem S., Ransohoff R. Inflammatory progressive multifocal leukoencephalopathy in human immunodeficiency virus-negative patients // Ann. Neurol. 2007. Vol. 62. P. 34–39.
13. Rakhmanova A.G. HIV infection. Clinic and treatment. St. Petersburg: Publishing house «SSZ», 2000, 370 p. (In Russ.).
Review
For citations:
Konkova-Reidman A.B., Mikheeva T.V., Veksey A.A., Smirnova N.V., Ermolenko Yu.Y., Radzikhovskaya M.V. Аnalysis of cases of progressive multifocal leukethephalopathy in patients with HIV infection: clinical, epidemiological, diagnostic and therapeutic aspects of the problem. HIV Infection and Immunosuppressive Disorders. 2020;12(4):81-86. (In Russ.) https://doi.org/10.22328/2077-9828-2020-12-4-81-86
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